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    STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [ Homo sapiens ]

    Gene ID: 10254, updated on 12-May-2012
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    Summary

    Official Symbol
    STAM2provided by HGNC
    Official Full Name
    signal transducing adaptor molecule (SH3 domain and ITAM motif) 2provided by HGNC
    Primary source
    HGNC:11358
    See related
    Ensembl:ENSG00000115145; HPRD:05876; MIM:606244; Vega:OTTHUMG00000131885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Hbp; STAM2A; STAM2B; DKFZp564C047
    Summary
    The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    2q23.3
    Sequence :
    Chromosome: 2; NC_000002.11 (152973315..153032506, complement)
    See STAM2 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 5A Neighboring gene calcium channel, voltage-dependent, beta 4 subunit Neighboring gene ribosomal protein L30 pseudogene 2 Neighboring gene formin-like 2 Neighboring gene nuclear distribution gene C homolog (A. nidulans) pseudogene 1 Neighboring gene PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Regulation of epidermal growth factor receptor ubiquitination and trafficking by the USP8·STAM complex. Berlin I, et al. J Biol Chem, 2010 Nov 5. PMID 20736164.

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. PTP1B targets the endosomal sorting machinery; dephosphorylation of regulatory sites on the endosomal sorting complex is required for transport component STAM2
      Title: PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2.
    2. STAMs function prominently in endoplasmic reticulum-to-Golgi trafficking, most likely through direct interactions with the coat protein II complex
      Title: STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking.
    3. Rin1 regulates EGFR degradation in cooperation with STAM
      Title: Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation.
    4. Data suggested that association with hepatocyte growth factor-regulated tyrosine kinase substrate is a prerequisite for STAM2 function in early endosome.
      Title: Association with Hrs is required for the early endosomal localization, stability, and function of STAM.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O75886 Q15038 DAZAP2    HPRD  PubMed  
    O75886 P00533 EGFR    HPRD  PubMed  
    O75886 P42566 EPS15    HPRD  PubMed  
    O75886 O14964 HGS    HPRD  PubMed  
    O75886 P23458 JAK1    HPRD  PubMed  
    O75886 O60674 JAK2    HPRD  PubMed  
    O75886 P52333 JAK3    HPRD  PubMed  
    O75886 Q969R5 L3MBTL2    HPRD  PubMed  
    O75886 Q9Y3C5 RNF11    HPRD  PubMed  
    O75886 O95630 STAMBP    HPRD  PubMed  
    O75886 P29597 TYK2    HPRD  PubMed  
    O75886 Q9NRR5 UBQLN4    HPRD  PubMed  
    O75886 P40818 USP8    HPRD  PubMed  
    O75886 Q8IZH2 XRN1    HPRD  PubMed  
    BioGRID:115548 BioGRID:117030 CBX5    BioGRID  PubMed Protein-peptide 
    BioGRID:115548 BioGRID:115143 DAZAP2    BioGRID  PubMed Two-hybrid 
    BioGRID:115548 BioGRID:108374 EPS15    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115548 BioGRID:114593 HGS    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Two-hybrid 
    BioGRID:115548 BioGRID:109919 JAK1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:115548 BioGRID:109920 JAK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115548 BioGRID:109921 JAK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115548 BioGRID:123753 L3MBTL2    BioGRID  PubMed Two-hybrid 
    BioGRID:115548 BioGRID:115863 STAMBP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:115548 BioGRID:113148 TYK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115548 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115548 BioGRID:113169 UBE2D1    BioGRID  PubMed Biochemical Activity 
    BioGRID:115548 BioGRID:113170 UBE2D2    BioGRID  PubMed Biochemical Activity 
    BioGRID:115548 BioGRID:113171 UBE2D3    BioGRID  PubMed Biochemical Activity 
    BioGRID:115548 BioGRID:113176 UBE2H    BioGRID  PubMed Biochemical Activity 
    BioGRID:115548 BioGRID:31215 UBI4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115548 BioGRID:114555 USP8    BioGRID  PubMed Affinity Capture-Western; PCA; Protein-peptide; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • EGFR downregulation, organism-specific biosystem (from REACTOME)
      EGFR downregulation, organism-specific biosystemRegulation of receptor tyrosine kinase (RTK) activity is implicated in the control of almost all cellular functions. One of the best understood RTKs is epidermal growth factor receptor (EGFR). Growth...
    • ESCRT-0 complex, organism-specific biosystem (from KEGG)
      ESCRT-0 complex, organism-specific biosystemStructural complex; Genetic information processing; Protein processing
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem (from REACTOME)
      Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystemMany plasma membrane proteins are in a constant flux throughout the internal trafficking pathways of the cell. Some receptors are continuously internalized into recycling endosomes and returned to th...
    • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
    • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common ga...
    • IL2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL2-mediated signaling events, organism-specific biosystem
      IL2-mediated signaling events
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cellular membrane organization TAS
    Traceable Author Statement
    more info
    		  
    endosome transport TAS
    Traceable Author Statement
    more info
    		  
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    signal transducing adapter molecule 2
    Names
    signal transducing adapter molecule 2
    STAM-2
    HSE1 homolog
    Hrs-binding protein
    STAM-like protein containing SH3 and ITAM domains 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005843.4 → NP_005834.4  signal transducing adapter molecule 2

      Status: REVIEWED

      Source sequence(s)
      AC079790, BC028740
      Consensus CDS
      CCDS2196.1
      UniProtKB/Swiss-Prot
      O75886
      Related
      ENSP00000263904, OTTHUMP00000162711, ENST00000263904, OTTHUMT00000254835
      Conserved Domains (3) summary
      cd00174
      Location:206 – 257
      Blast Score: 200
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd03568
      Location:9 – 143
      Blast Score: 532
      VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
      smart00726
      Location:166 – 184
      Blast Score: 81
      UIM; Ubiquitin-interacting motif.

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      152973315..153032506, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      144859495..144918505, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC079790.6 AAY14712.1
    genomic AL161997.1 None
    genomic CH471058.2 EAX11490.1
      EAX11491.1
      EAX11492.1
    mRNA AF042273.1 AAC63963.1
    mRNA AF042274.1 AAC63964.1
    mRNA AK023490.1 None
    mRNA AK292265.1 BAF84954.1
    mRNA AK292847.1 BAF85536.1
    mRNA AK310863.1 None
    mRNA AL133600.1 CAB63735.1
    mRNA BC022277.1 None
    mRNA BC028740.2 AAH28740.1
    mRNA BI548350.1 None
    mRNA BQ000599.1 None
    other-genetic AM393419.1 CAL38297.1
    other-genetic DQ892427.2 ABM83353.1
    other-genetic DQ895641.2 ABM86567.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75886.1 GenPept UniProtKB/Swiss-Prot:O75886
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

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