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ADAM17 ADAM metallopeptidase domain 17 [ Myotis lucifugus (little brown bat) ]

Gene ID: 102425078, updated on 30-Mar-2024

Summary

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Gene symbol
ADAM17
Gene description
ADAM metallopeptidase domain 17
See related
Ensembl:ENSMLUG00000010676
Gene type
protein coding
RefSeq status
MODEL
Organism
Myotis lucifugus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yangochiroptera; Vespertilionidae; Myotis
Orthologs
human mouse all
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Genomic context

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See ADAM17 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
21
Annotation release Status Assembly Chr Location
102 current Myoluc2.0 (GCF_000147115.1) Unplaced Scaffold NW_005871457.1 (58939..102942, complement)

NW_005871457.1Genomic Context describing neighboring genes Neighboring gene cleavage and polyadenylation specific factor 3 Neighboring gene isoamyl acetate hydrolyzing esterase 1 (putative) Neighboring gene uncharacterized LOC111823151 Neighboring gene U6 spliceosomal RNA Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta Neighboring gene TATA-box binding protein associated factor, RNA polymerase I subunit B

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_005871457 Unplaced Scaffold Reference Myoluc2.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Myotis lucifugus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Myoluc2.0

Genomic

  1. NW_005871457.1 Reference Myoluc2.0

    Range
    58939..102942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023743723.1 → XP_023599491.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X2

    Conserved Domains (4) summary
    smart00050
    Location:454 → 530
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:193 → 447
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:26 → 122
    Pep_M12B_propep; Reprolysin family propeptide
    pfam16698
    Location:551 → 611
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

  2. XM_006102334.3 → XP_006102396.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X1

    UniProtKB/TrEMBL
    G1PGH7
    Related
    ENSMLUP00000009742.2, ENSMLUT00000010686.2
    Conserved Domains (5) summary
    smart00050
    Location:484 → 560
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:223 → 477
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:56 → 162
    Pep_M12B_propep; Reprolysin family propeptide
    pfam13574
    Location:247 → 460
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
    pfam16698
    Location:581 → 641
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

  3. XM_023743727.1 → XP_023599495.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X5

    Conserved Domains (4) summary
    smart00050
    Location:484 → 560
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:223 → 477
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:56 → 152
    Pep_M12B_propep; Reprolysin family propeptide
    pfam16698
    Location:581 → 641
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

  4. XM_023743726.1 → XP_023599494.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X4

    Conserved Domains (4) summary
    smart00050
    Location:484 → 560
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:223 → 477
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:56 → 152
    Pep_M12B_propep; Reprolysin family propeptide
    pfam16698
    Location:581 → 641
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

  5. XM_023743725.1 → XP_023599493.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X3

    Conserved Domains (4) summary
    smart00050
    Location:484 → 560
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:223 → 477
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:56 → 152
    Pep_M12B_propep; Reprolysin family propeptide
    pfam16698
    Location:581 → 641
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

RNA

  1. XR_001351056.2 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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