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VAV3 vav guanine nucleotide exchange factor 3 [ Bubalus bubalis (water buffalo) ]

Gene ID: 102412230, updated on 10-Mar-2024

Summary

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Gene symbol
VAV3
Gene description
vav guanine nucleotide exchange factor 3
See related
EnsemblRapid:ENSBALG00030021062
Gene type
protein coding
RefSeq status
MODEL
Organism
Bubalus bubalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bubalus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
37
Annotation release Status Assembly Chr Location
103 current NDDB_SH_1 (GCF_019923935.1) 6 NC_059162.1 (35275613..35919359)
102 previous assembly NDDB_DH_1 (GCF_019923925.1) 6 NC_058348.1 (34873557..35525775)

Chromosome 6 - NC_059162.1Genomic Context describing neighboring genes Neighboring gene calcium-binding mitochondrial carrier protein SCaMC-1 Neighboring gene 40S ribosomal protein S6-like Neighboring gene calcium-binding mitochondrial carrier protein SCaMC-1 Neighboring gene uncharacterized LOC123334038 Neighboring gene uncharacterized LOC123334039

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide exchange factor VAV3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Bubalus bubalis Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NDDB_SH_1 Primary Assembly

Genomic

  1. NC_059162.1 Reference NDDB_SH_1 Primary Assembly

    Range
    35275613..35919359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_044944623.2 → XP_044800558.1  guanine nucleotide exchange factor VAV3 isoform X4

    Conserved Domains (6) summary
    smart00109
    Location:427 → 475
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd10407
    Location:579 → 681
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:704 → 759
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:509 → 570
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:106 → 282
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:296 → 419
    PH_Vav; Vav pleckstrin homology (PH) domain

  2. XM_044944624.2 → XP_044800559.1  guanine nucleotide exchange factor VAV3 isoform X4

    Conserved Domains (6) summary
    smart00109
    Location:427 → 475
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd10407
    Location:579 → 681
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:704 → 759
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:509 → 570
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:106 → 282
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:296 → 419
    PH_Vav; Vav pleckstrin homology (PH) domain

  3. XM_044944626.2 → XP_044800561.1  guanine nucleotide exchange factor VAV3 isoform X4

    Conserved Domains (6) summary
    smart00109
    Location:427 → 475
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd10407
    Location:579 → 681
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:704 → 759
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:509 → 570
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:106 → 282
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:296 → 419
    PH_Vav; Vav pleckstrin homology (PH) domain

  4. XM_044944625.2 → XP_044800560.1  guanine nucleotide exchange factor VAV3 isoform X4

    Conserved Domains (6) summary
    smart00109
    Location:427 → 475
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd10407
    Location:579 → 681
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:704 → 759
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:509 → 570
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:106 → 282
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:296 → 419
    PH_Vav; Vav pleckstrin homology (PH) domain

  5. XM_044944628.2 → XP_044800563.1  guanine nucleotide exchange factor VAV3 isoform X4

    Conserved Domains (6) summary
    smart00109
    Location:427 → 475
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd10407
    Location:579 → 681
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:704 → 759
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:509 → 570
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:106 → 282
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:296 → 419
    PH_Vav; Vav pleckstrin homology (PH) domain

  6. XM_025288193.3 → XP_025143978.3  guanine nucleotide exchange factor VAV3 isoform X1

    Related
    ENSBALP00030039915.1, ENSBALT00030059284.1
    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:791 → 846
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein

  7. XM_044944622.2 → XP_044800557.2  guanine nucleotide exchange factor VAV3 isoform X5

  8. XM_044944620.2 → XP_044800555.1  guanine nucleotide exchange factor VAV3 isoform X3

    Related
    ENSBALP00030039863.1, ENSBALT00030059217.1
    Conserved Domains (7) summary
    cd10407
    Location:599 → 701
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:724 → 779
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:529 → 590
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:126 → 302
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:316 → 439
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd20869
    Location:439 → 497
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein
    cl00030
    Location:2 → 51
    CH_SF; calponin homology (CH) domain superfamily

  9. XM_025288194.3 → XP_025143979.1  guanine nucleotide exchange factor VAV3 isoform X2

    Related
    ENSBALP00030039787.1, ENSBALT00030059127.1
    Conserved Domains (7) summary
    cd10407
    Location:599 → 701
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:724 → 779
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:529 → 590
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:126 → 302
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:316 → 439
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd20869
    Location:439 → 497
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein
    cl00030
    Location:2 → 51
    CH_SF; calponin homology (CH) domain superfamily
Nucleotide Protein
Heading Accession and Version

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