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MCL1 MCL1 apoptosis regulator, BCL2 family member [ Bubalus bubalis (water buffalo) ]

Gene ID: 102403565, updated on 10-Mar-2024

Summary

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Gene symbol
MCL1
Gene description
MCL1 apoptosis regulator, BCL2 family member
See related
EnsemblRapid:ENSBALG00030018662
Gene type
protein coding
RefSeq status
MODEL
Organism
Bubalus bubalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bubalus
Orthologs
human mouse all
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Genomic context

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See MCL1 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
3
Annotation release Status Assembly Chr Location
103 current NDDB_SH_1 (GCF_019923935.1) 6 NC_059162.1 (20233176..20237923)
102 previous assembly NDDB_DH_1 (GCF_019923925.1) 6 NC_058348.1 (20040706..20045453)

Chromosome 6 - NC_059162.1Genomic Context describing neighboring genes Neighboring gene golgi phosphoprotein 3 like Neighboring gene ubiquitin-40S ribosomal protein S27a-like Neighboring gene endosulfine alpha Neighboring gene ADAMTS like 4 Neighboring gene transfer RNA serine (anticodon GGA)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitochondrial fusion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
induced myeloid leukemia cell differentiation protein Mcl-1
Names
BCL2 family apoptosis regulator
MCL1, BCL2 family apoptosis regulator
induced myeloid leukemia cell differentiation protein Mcl-1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Bubalus bubalis Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NDDB_SH_1 Primary Assembly

Genomic

  1. NC_059162.1 Reference NDDB_SH_1 Primary Assembly

    Range
    20233176..20237923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006058113.3 → XP_006058175.2  induced myeloid leukemia cell differentiation protein Mcl-1

    Related
    ENSBALP00030035225.1, ENSBALT00030052383.1
    Conserved Domains (2) summary
    cd06845
    Location:175 → 318
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    PHA03307
    Location:36 → 203
    PHA03307; transcriptional regulator ICP4; Provisional
Nucleotide Protein
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