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CNKSR2 connector enhancer of kinase suppressor of Ras 2 [ Bubalus bubalis (water buffalo) ]

Gene ID: 102401457, updated on 10-Mar-2024

Summary

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Gene symbol
CNKSR2
Gene description
connector enhancer of kinase suppressor of Ras 2
See related
EnsemblRapid:ENSBALG00030037643
Gene type
protein coding
RefSeq status
MODEL
Organism
Bubalus bubalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bubalus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X
Exon count:
23
Annotation release Status Assembly Chr Location
103 current NDDB_SH_1 (GCF_019923935.1) X NC_059181.1 (19993592..20277992)
102 previous assembly NDDB_DH_1 (GCF_019923925.1) X NC_058367.1 (20685677..20970371)

Chromosome X - NC_059181.1Genomic Context describing neighboring genes Neighboring gene 60S acidic ribosomal protein P2-like Neighboring gene 60S ribosomal protein L27-like Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC123332040 Neighboring gene thymosin beta-4-like Neighboring gene kelch like family member 34 Neighboring gene small muscle protein X-linked

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De Novo Transcriptome Assembly of the Chinese Swamp Buffalo by RNA Sequencing and SSR Marker Discovery. Deng T, et al. PLoS One, 2016. PMID 26766209, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
connector enhancer of kinase suppressor of ras 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Bubalus bubalis Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NDDB_SH_1 Primary Assembly

Genomic

  1. NC_059181.1 Reference NDDB_SH_1 Primary Assembly

    Range
    19993592..20277992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006048929.4 → XP_006048991.1  connector enhancer of kinase suppressor of ras 2 isoform X5

    See identical proteins and their annotated locations for XP_006048991.1

    Related
    ENSBALP00030069746.1, ENSBALT00030104358.1
    Conserved Domains (8) summary
    cd09511
    Location:8 → 76
    SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
    smart00454
    Location:8 → 73
    SAM; Sterile alpha motif
    cd00992
    Location:222 → 294
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01260
    Location:559 → 672
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam00169
    Location:573 → 669
    PH; PH domain
    pfam06663
    Location:341 → 561
    DUF1170; Protein of unknown function (DUF1170)
    pfam10534
    Location:84 → 176
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    pfam15499
    Location:139 → 218
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

  2. XM_006048925.4 → XP_006048987.1  connector enhancer of kinase suppressor of ras 2 isoform X1

    See identical proteins and their annotated locations for XP_006048987.1

    Related
    ENSBALP00030069804.1, ENSBALT00030104437.1
    Conserved Domains (8) summary
    cd09511
    Location:8 → 76
    SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
    smart00454
    Location:8 → 73
    SAM; Sterile alpha motif
    cd00992
    Location:222 → 294
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01260
    Location:559 → 672
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam00169
    Location:573 → 669
    PH; PH domain
    pfam06663
    Location:341 → 561
    DUF1170; Protein of unknown function (DUF1170)
    pfam10534
    Location:84 → 176
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    pfam15499
    Location:139 → 218
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

  3. XM_006048926.4 → XP_006048988.1  connector enhancer of kinase suppressor of ras 2 isoform X2

    See identical proteins and their annotated locations for XP_006048988.1

    Related
    ENSBALP00030069834.1, ENSBALT00030104469.1
    Conserved Domains (8) summary
    cd09511
    Location:8 → 76
    SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
    smart00454
    Location:8 → 73
    SAM; Sterile alpha motif
    cd00992
    Location:222 → 294
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01260
    Location:529 → 642
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam00169
    Location:543 → 639
    PH; PH domain
    pfam06663
    Location:341 → 531
    DUF1170; Protein of unknown function (DUF1170)
    pfam10534
    Location:84 → 176
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    pfam15499
    Location:139 → 218
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

  4. XM_006048927.4 → XP_006048989.1  connector enhancer of kinase suppressor of ras 2 isoform X3

    See identical proteins and their annotated locations for XP_006048989.1

    Related
    ENSBALP00030069823.1, ENSBALT00030104457.1
    Conserved Domains (8) summary
    cd09511
    Location:8 → 76
    SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
    smart00454
    Location:8 → 73
    SAM; Sterile alpha motif
    cd00992
    Location:222 → 270
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01260
    Location:510 → 623
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam00169
    Location:524 → 620
    PH; PH domain
    pfam06663
    Location:292 → 512
    DUF1170; Protein of unknown function (DUF1170)
    pfam10534
    Location:84 → 176
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    pfam15499
    Location:139 → 218
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

  5. XM_025277119.3 → XP_025132904.1  connector enhancer of kinase suppressor of ras 2 isoform X4

    Conserved Domains (5) summary
    cd09511
    Location:8 → 76
    SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
    cd00992
    Location:222 → 270
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01260
    Location:480 → 593
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam06663
    Location:292 → 408
    DUF1170; Protein of unknown function (DUF1170)
    pfam10534
    Location:84 → 176
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
Nucleotide Protein
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