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    DCAF7 DDB1 and CUL4 associated factor 7 [ Homo sapiens ]

    Gene ID: 10238, updated on 11-May-2012
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    Summary

    Official Symbol
    DCAF7provided by HGNC
    Official Full Name
    DDB1 and CUL4 associated factor 7provided by HGNC
    Primary source
    HGNC:30915
    See related
    Ensembl:ENSG00000136485; HPRD:09340; MIM:605973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AN11; HAN11; WDR68; SWAN-1
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    Genomic context

    Location :
    17q23.3
    Sequence :
    Chromosome: 17; NC_000017.10 (61627822..61671641)
    See DCAF7 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 pseudogene Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 6 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I Neighboring gene family with sequence similarity 136, member A pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Altun M, et al. Chem Biol, 2011 Nov 23. PMID 22118674.
    2. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation. Miyata Y, et al. Biochim Biophys Acta, 2011 Oct. PMID 21777625.

    See all (27) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. DYRK1A binds specifically to WDR68 in cells; the binding, but not the phosphorylation event, induces the nuclear translocation of WDR68.
      Title: DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation.
    2. Han11 was required to allow coupling of MEKK1 to DYRK1 and HIPK2.
      Title: The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions.
    3. that AN11 may be a physiological regulator of GLI1 transcriptional activity
      Title: HAN11 binds mDia1 and controls GLI1 transcriptional activity.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Many sequence variants affecting diversity of adult human height.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P61962 O00238 BMPR1B    HPRD  PubMed  
    P61962 Q9Y463 DYRK1B    HPRD  PubMed  
    P61962 P61981 YWHAG    HPRD  PubMed  
    BioGRID:115532 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115532 BioGRID:108192 DYRK1A    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:115532 BioGRID:114596 DYRK1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115532 BioGRID:114023 DYRK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115532 BioGRID:207994 Dynll1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115532 BioGRID:116806 FAF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115532 BioGRID:110378 MAP3K1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115532 BioGRID:121134 PARD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115532 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115532 BioGRID:207577 Spag5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115532 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115532 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115532 BioGRID:113365 YWHAH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115532 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the DCAF7 gene: The DCAF7 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein ubiquitination IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    CUL4 RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    DDB1- and CUL4-associated factor 7
    Names
    DDB1- and CUL4-associated factor 7
    WD-repeat protein
    human anthocyanin
    WD repeat domain 68
    WD repeat-containing protein 68
    WD repeat-containing protein An11 homolog
    seven-WD-repeat protein of the AN11 family-1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005828.3 → NP_005819.3  DDB1- and CUL4-associated factor 7

      Status: VALIDATED

      Source sequence(s)
      AC113554, BM673647, DA230140, U94747
      UniProtKB/Swiss-Prot
      P61962
      Related
      ENSP00000308344, ENST00000310827
      Conserved Domains (1) summary
      cl02567
      Location:19 – 295
      Blast Score: 163
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      61627822..61671641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      56994271..57039588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001003725.1: Suppressed sequence

      Description
      NM_001003725.1: This RefSeq was permanently suppressed because it contains the wrong CDS.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC113554.9 (11465..55283) None
    genomic CH471109.2 EAW94305.1
      EAW94306.1
    mRNA AA206721.1 None
    mRNA AA634196.1 None
    mRNA AI580937.1 None
    mRNA AK022145.1 None
    mRNA AK025925.1 None
    mRNA AK026008.1 None
    mRNA AK130672.1 None
    mRNA AK294925.1 BAG58007.1
    mRNA AK303212.1 BAG64301.1
    mRNA AL832440.1 None
    mRNA BC001264.1 AAH01264.1
    mRNA BC024682.1 None
    mRNA BC027489.1 None
    mRNA BE889428.1 None
    mRNA BF058090.1 None
    mRNA BF507629.1 None
    mRNA BG684075.1 None
    mRNA BG819062.1 None
    mRNA BM272287.1 None
    mRNA BM559804.1 None
    mRNA BM673647.1 None
    mRNA BQ221019.1 None
    mRNA BQ435051.1 None
    mRNA BX648608.1 None
    mRNA CB162675.1 None
    mRNA CD245570.1 None
    mRNA DA230140.1 None
    mRNA U94747.1 AAC18913.1
    other-genetic DQ891233.2 ABM82159.1
    other-genetic DQ894417.2 ABM85343.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61962.1 GenPept UniProtKB/Swiss-Prot:P61962
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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