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LRRC17 leucine rich repeat containing 17 [ Homo sapiens (human) ]

Gene ID: 10234, updated on 7-May-2016
Official Symbol
LRRC17provided by HGNC
Official Full Name
leucine rich repeat containing 17provided by HGNC
Primary source
HGNC:HGNC:16895
See related
Ensembl:ENSG00000128606 HPRD:10059; Vega:OTTHUMG00000157210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P37NB
Orthologs
Location:
7q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (102912897..102945111)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102553344..102585558)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 13 Neighboring gene family with sequence similarity 185 member A Neighboring gene ribosomal protein L7a pseudogene 39 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 pseudogene Neighboring gene nuclear factor, erythroid 4 Neighboring gene armadillo repeat containing 10 Neighboring gene crystallin zeta pseudogene 1

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
bone marrow development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT osteoblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
leucine-rich repeat-containing protein 17
Names
37 kDa leucine-rich repeat (LRR) protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031692.2NP_001026862.1  leucine-rich repeat-containing protein 17 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001026862.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC073127, AI961444, BC027903, DA749917
    Consensus CDS
    CCDS34721.1
    UniProtKB/Swiss-Prot
    Q8N6Y2
    Related
    ENSP00000344242, OTTHUMP00000211714, ENST00000339431, OTTHUMT00000347930
    Conserved Domains (4) summary
    cd00116
    Location:267351
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam12799
    Location:294332
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:272328
    LRR_8; Leucine rich repeat
    sd00033
    Location:6381
    LRR_RI; leucine-rich repeat [structural motif]
  2. NM_005824.2NP_005815.2  leucine-rich repeat-containing protein 17 isoform 2 precursor

    See identical proteins and their annotated locations for NP_005815.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' UTR and coding region, compared to variant 1, that causes a frameshift. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC073127, AI961444, DA749917, U32907
    Consensus CDS
    CCDS5727.1
    UniProtKB/Swiss-Prot
    Q8N6Y2
    Related
    ENSP00000249377, OTTHUMP00000211713, ENST00000249377, OTTHUMT00000347929
    Conserved Domains (4) summary
    pfam12799
    Location:105142
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:106164
    LRR_8; Leucine rich repeat
    sd00031
    Location:6383
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:217246
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    102912897..102945111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250108.1XP_005250165.1  

    See identical proteins and their annotated locations for XP_005250165.1

    UniProtKB/Swiss-Prot
    Q8N6Y2
    Conserved Domains (4) summary
    cd00116
    Location:267351
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam12799
    Location:294332
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:272328
    LRR_8; Leucine rich repeat
    sd00033
    Location:6381
    LRR_RI; leucine-rich repeat [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    102486708..102518921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)