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ryr2a ryanodine receptor 2a (cardiac) [ Xiphophorus maculatus (southern platyfish) ]

Gene ID: 102235428, updated on 10-Mar-2024

Summary

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Gene symbol
ryr2a
Gene description
ryanodine receptor 2a (cardiac)
See related
Ensembl:ENSXMAG00000014335
Gene type
protein coding
RefSeq status
MODEL
Organism
Xiphophorus maculatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae; Xiphophorus
Also known as
ryr2
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 10
Exon count:
115
Annotation release Status Assembly Chr Location
102 current X_maculatus-5.0-male (GCF_002775205.1) 10 NC_036452.1 (24614553..24758931)
101 previous assembly Xiphophorus_maculatus-4.4.2 (GCF_000241075.1) Unplaced Scaffold NW_005372496.1 (359664..506431)

Chromosome 10 - NC_036452.1Genomic Context describing neighboring genes Neighboring gene BMS1 ribosome biogenesis factor Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase Neighboring gene muscarinic acetylcholine receptor M1 Neighboring gene 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ryanodine-sensitive calcium-release channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of calcium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ryanodine receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xiphophorus maculatus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference X_maculatus-5.0-male Primary Assembly

Genomic

  1. NC_036452.1 Reference X_maculatus-5.0-male Primary Assembly

    Range
    24614553..24758931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023340674.1 → XP_023196442.1  ryanodine receptor 2 isoform X1

    UniProtKB/TrEMBL
    M4AIX3
    Conserved Domains (12) summary
    cd12877
    Location:642 → 793
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1070 → 1202
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1384 → 1530
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4724 → 4884
    Ion_trans; Ion transport protein
    pfam01365
    Location:443 → 636
    RYDR_ITPR; RIH domain
    pfam02026
    Location:846 → 934
    RyR; RyR domain
    pfam02815
    Location:214 → 394
    MIR; MIR domain
    pfam06459
    Location:4315 → 4605
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3818 → 3931
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:4015 → 4067
    EF-hand_7; EF-hand domain pair
    pfam14070
    Location:3938 → 3985
    YjfB_motility; Putative motility protein
    cl19745
    Location:9 → 204
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  2. XM_023340676.1 → XP_023196444.1  ryanodine receptor 2 isoform X3

    UniProtKB/TrEMBL
    M4AIX3
    Conserved Domains (12) summary
    cd12877
    Location:642 → 793
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1070 → 1202
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1384 → 1530
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4718 → 4878
    Ion_trans; Ion transport protein
    pfam01365
    Location:443 → 636
    RYDR_ITPR; RIH domain
    pfam02026
    Location:846 → 934
    RyR; RyR domain
    pfam02815
    Location:214 → 394
    MIR; MIR domain
    pfam06459
    Location:4309 → 4599
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3812 → 3925
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:4009 → 4061
    EF-hand_7; EF-hand domain pair
    pfam14070
    Location:3932 → 3979
    YjfB_motility; Putative motility protein
    cl19745
    Location:9 → 204
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  3. XM_023340677.1 → XP_023196445.1  ryanodine receptor 2 isoform X5

    UniProtKB/TrEMBL
    M4AIX3
    Conserved Domains (12) summary
    cd12877
    Location:642 → 793
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1070 → 1202
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1384 → 1530
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4708 → 4868
    Ion_trans; Ion transport protein
    pfam01365
    Location:443 → 636
    RYDR_ITPR; RIH domain
    pfam02026
    Location:846 → 934
    RyR; RyR domain
    pfam02815
    Location:214 → 394
    MIR; MIR domain
    pfam06459
    Location:4299 → 4589
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3802 → 3915
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:3999 → 4051
    EF-hand_7; EF-hand domain pair
    pfam14070
    Location:3922 → 3969
    YjfB_motility; Putative motility protein
    cl19745
    Location:9 → 204
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  4. XM_023340675.1 → XP_023196443.1  ryanodine receptor 2 isoform X2

    UniProtKB/TrEMBL
    M4AIX3
    Conserved Domains (12) summary
    cd12877
    Location:642 → 793
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1070 → 1202
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1384 → 1530
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4723 → 4883
    Ion_trans; Ion transport protein
    pfam01365
    Location:443 → 636
    RYDR_ITPR; RIH domain
    pfam02026
    Location:846 → 934
    RyR; RyR domain
    pfam02815
    Location:214 → 394
    MIR; MIR domain
    pfam06459
    Location:4314 → 4604
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3817 → 3930
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:4014 → 4066
    EF-hand_7; EF-hand domain pair
    pfam14070
    Location:3937 → 3984
    YjfB_motility; Putative motility protein
    cl19745
    Location:9 → 204
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  5. XM_023340678.1 → XP_023196446.1  ryanodine receptor 2 isoform X6

    UniProtKB/TrEMBL
    M4AIX3
    Conserved Domains (12) summary
    cd12877
    Location:642 → 793
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1070 → 1202
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1384 → 1530
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4707 → 4867
    Ion_trans; Ion transport protein
    pfam01365
    Location:443 → 636
    RYDR_ITPR; RIH domain
    pfam02026
    Location:846 → 934
    RyR; RyR domain
    pfam02815
    Location:214 → 394
    MIR; MIR domain
    pfam06459
    Location:4298 → 4588
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3801 → 3914
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:3998 → 4050
    EF-hand_7; EF-hand domain pair
    pfam14070
    Location:3921 → 3968
    YjfB_motility; Putative motility protein
    cl19745
    Location:9 → 204
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  6. XM_014473078.2 → XP_014328564.1  ryanodine receptor 2 isoform X4

    UniProtKB/TrEMBL
    M4AIX3
    Related
    ENSXMAP00000014417.2, ENSXMAT00000014437.2
    Conserved Domains (13) summary
    smart00472
    Location:274 → 363
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cd12877
    Location:642 → 793
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1070 → 1202
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    pfam00520
    Location:4714 → 4874
    Ion_trans; Ion transport protein
    pfam01365
    Location:443 → 631
    RYDR_ITPR; RIH domain
    pfam02026
    Location:846 → 935
    RyR; RyR domain
    pfam02815
    Location:214 → 394
    MIR; MIR domain
    pfam06459
    Location:4305 → 4595
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3808 → 3921
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:4005 → 4057
    EF-hand_7; EF-hand domain pair
    cd12879
    Location:1384 → 1530
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    cl08302
    Location:4005 → 4058
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl19745
    Location:9 → 204
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  7. XM_023340679.1 → XP_023196447.1  ryanodine receptor 2 isoform X7

    UniProtKB/TrEMBL
    M4AIX3
    Conserved Domains (10) summary
    cd12877
    Location:1 → 151
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:428 → 560
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:742 → 888
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4082 → 4242
    Ion_trans; Ion transport protein
    pfam01365
    Location:1459 → 1672
    RYDR_ITPR; RIH domain
    pfam02026
    Location:204 → 292
    RyR; RyR domain
    pfam06459
    Location:3673 → 3963
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3176 → 3289
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:3373 → 3425
    EF-hand_7; EF-hand domain pair
    pfam14070
    Location:3296 → 3343
    YjfB_motility; Putative motility protein
Nucleotide Protein Strain
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