TRIB1 tribbles homolog 1 (Drosophila) [Homo sapiens] - Gene

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Summary

Official Symbol: TRIB1provided by HGNC
Official Full Name: tribbles homolog 1 (Drosophila)provided by HGNC
Primary source: HGNC:16891
See related: Ensembl:ENSG00000173334; HPRD:09863; MIM:609461; Vega:OTTHUMG00000165007
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C8FW; GIG2; TRB1; SKIP1

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Genomic context

Location :: 8q24.13

Sequence :: Chromosome: 8; NC_000008.10 (126442563..126450645)

See TRIB1 in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show no differences in triglyceride or total cholesterol levels in relation to any allelic variants of ANGPTL3, CILP2, or TRIB1 SNPs.
Title: Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke.
TRIB1 polymorphisms were associated with increased risk of ischemic heart disease and myocardial infarction.
Title: TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population.
Tribbles homolog 1 (Trib1) functions as a negative regulator of retinoic acid receptors.
Title: Human Tribbles homolog 1 functions as a negative regulator of retinoic acid receptor.
Trib1 may be a key mediator between the RTK-MAPK pathway and the C/EBP transcription factor in myeloid leukemogenesis.
Title: Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Polymorphism at the TRIB1 gene modulates plasma lipid levels: insight from the Spanish familial hypercholesterolemia cohort study.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.
low trb-1 expression was associated with inactive C/EBPalpha
Title: Tribbles-1 and -2 are tumour suppressors, down-regulated in human acute myeloid leukaemia.
Data show that SNPs associated with TG in normolipidemic samples, including APOA5, TRIB1, TBL2, GCKR, GALNT2 and ANGPTL3 were significantly associated with HLP types 2B, 3, 4 and 5.
Title: A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.
Observational study of gene-disease association. (HuGE Navigator)
Title: TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

Submit: New GeneRIF Correction See all (13)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.

Common variants at 30 loci contribute to polygenic dyslipidemia.

Genetic variants influencing circulating lipid levels and risk of coronary artery disease.

Genome-wide association of lipid-lowering response to statins in combined study populations.

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.

Newly identified loci that influence lipid concentrations and risk of coronary artery disease.

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_079471.1	NP_000688.1	ALOX12	BIND	PubMed	12-LOX interacts with C8FW.
Q96RU8	P18054	ALOX12	HPRD	PubMed
Q96RU8	Q02750	MAP2K1	HPRD	PubMed
Q96RU8	P45985	MAP2K4	HPRD	PubMed
Q96RU8	O14733	MAP2K7	HPRD	PubMed
BioGRID:115516	BioGRID:106740	ALOX12	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
NOT ATP binding	TAS Traceable Author Statement more info
mitogen-activated protein kinase kinase binding	IDA Inferred from Direct Assay more info	PubMed
NOT protein kinase activity	TAS Traceable Author Statement more info
protein kinase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info
ubiquitin protein ligase binding	ISS Inferred from Sequence or Structural Similarity more info
ubiquitin-protein ligase regulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of lipopolysaccharide-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of sequence-specific DNA binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of sequence-specific DNA binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
negative regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
NOT protein phosphorylation	TAS Traceable Author Statement more info
regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: tribbles homolog 1

Names: tribbles homolog 1; GIG-2; TRB-1; tribbles-like protein 1; G-protein-coupled receptor induced protein; G-protein-coupled receptor-induced protein 2; phosphoprotein regulated by mitogenic pathways; G-protein-coupled receptor-induced gene 2 protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025195.2 → NP_079471.1 tribbles homolog 1

Status: VALIDATED

Source sequence(s)

AF205437, AL832388, BC063292

Consensus CDS

CCDS6357.1

UniProtKB/Swiss-Prot

Q96RU8

Related

ENSP00000312150, OTTHUMP00000228187, ENST00000311922, OTTHUMT00000381430

Conserved Domains (2) summary

smart00220
Location:105 – 338
Blast Score: 299

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl09925
Location:154 – 338
Blast Score: 241

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

126442563..126450645

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

121766406..121774484

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC091114.11 (38847..46929)	None
genomic	CH471060.1	EAW92085.1
genomic	FB713563.1	CAS91544.1
genomic	FJ515869.1	ACS13752.1
genomic	JA528975.1	CCD74463.1
mRNA	AF205437.1	AAG35663.1
mRNA	AF250310.1	AAK58174.1
mRNA	AJ000480.1	CAA04119.1
mRNA	AK001319.1	None
mRNA	AK022787.1	None
mRNA	AK297539.1	BAG59938.1
mRNA	AL832388.1	CAI46181.1
mRNA	BC012441.1	None
mRNA	BC063292.1	AAH63292.1