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SSX3 SSX family member 3 [ Homo sapiens (human) ]

Gene ID: 10214, updated on 22-May-2016
Official Symbol
SSX3provided by HGNC
Official Full Name
SSX family member 3provided by HGNC
Primary source
HGNC:HGNC:11337
See related
Ensembl:ENSG00000165584 HPRD:02265; MIM:300325; Vega:OTTHUMG00000021489
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT5.3
Summary
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. [provided by RefSeq, Jul 2013]
Orthologs
Location:
Xp11.23
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (48346428..48356753, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48205863..48216203, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ornithine aminotransferase pseudogene Neighboring gene SSX family pseudogene 9 Neighboring gene ornithine aminotransferase pseudogene Neighboring gene ornithine aminotransferase, mitochondrial-like

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC14495, MGC119054

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
negative regulation of nucleic acid-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
protein SSX3
Names
Kruppel-associated box containing gene product SSX3
cancer/testis antigen 5.3
synovial sarcoma, X breakpoint 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012561.1 RefSeqGene

    Range
    4955..15280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021014.3NP_066294.1  protein SSX3

    See identical proteins and their annotated locations for NP_066294.1

    Status: REVIEWED

    Source sequence(s)
    AA609599, AL606490, BC103862, DB444418, U90840
    Consensus CDS
    CCDS14291.1
    UniProtKB/Swiss-Prot
    Q99909
    Related
    ENSP00000298396, OTTHUMP00000023246, ENST00000298396, OTTHUMT00000056486
    Conserved Domains (3) summary
    cd07765
    Location:2461
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    pfam09514
    Location:155188
    SSXRD; SSXRD motif
    smart00349
    Location:2382
    KRAB; krueppel associated box

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    48346428..48356753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543885.1XP_011542187.1  

    See identical proteins and their annotated locations for XP_011542187.1

    UniProtKB/Swiss-Prot
    Q99909
    UniProtKB/TrEMBL
    A0A024R1B1
    Related
    ENSP00000366090, OTTHUMP00000023247, ENST00000376893, OTTHUMT00000056487
    Conserved Domains (2) summary
    cd07765
    Location:2461
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:2382
    KRAB; krueppel associated box

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    48237472..48247797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175711.1: Suppressed sequence

    Description
    NM_175711.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.