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    CDK6 cyclin-dependent kinase 6 [ Homo sapiens ]

    Gene ID: 1021, updated on 5-Feb-2012
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    Summary

    Official Symbol
    CDK6provided by HGNC
    Official Full Name
    cyclin-dependent kinase 6provided by HGNC
    Primary source
    HGNC:1777
    See related
    Ensembl:ENSG00000105810; HPRD:04533; MIM:603368; Vega:OTTHUMG00000131697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PLSTIRE
    Summary
    The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
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    Genomic context

    Location :
    7q21-q22
    Sequence :
    Chromosome: 7; NC_000007.13 (92234235..92465941, complement)
    See CDK6 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene EF-hand calcium-binding domain-containing protein 1-like Neighboring gene family with sequence similarity 133, member B Neighboring gene RNA, 7SL, cytoplasmic 7, pseudogene Neighboring gene sterile alpha motif domain containing 9

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Blazek D, et al. Genes Dev, 2011 Oct 15. PMID 22012619.
    2. NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. Mori T, et al. Cell Cycle, 2011 Oct 1. PMID 21952639.
    3. Isolated GH deficiency: mutation screening and copy number analysis of HMGA2 and CDK6 genes. Gorbenko del Blanco D, et al. Eur J Endocrinol, 2011 Oct. PMID 21803798.
    4. Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT). Reiner AP, et al. PLoS Genet, 2011 Jun. PMID 21738479.
    5. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. Okada Y, et al. PLoS Genet, 2011 Jun. PMID 21738478.

    See all (152) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. through regulation of expression of DNA damage response genes, CycK/Cdk12 protects cells from genomic instability
      Title: The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.
    2. In CDK6 in isolated growth hormone deficiency we found only known polymorphisms
      Title: Isolated GH deficiency: mutation screening and copy number analysis of HMGA2 and CDK6 genes.
    3. both CDK4 and CDK6 are prognostic markers and bona fide oncogenes in EAC.
      Title: Early G₁ cyclin-dependent kinases as prognostic markers and potential therapeutic targets in esophageal adenocarcinoma.
    4. Targeted inhibition of CDK4 activity may have a role in the treatment of cyclin D-overexpressing breast cancers.
      Title: Cyclin-dependent kinase 4-mediated phosphorylation inhibits Smad3 activity in cyclin D-overexpressing breast cancer cells.
    5. a mechanism for LPS signaling which involves a decrease in miR-107 leading to an increase in CDK6
      Title: Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclin-dependent kinase 6.
    6. The results obtained through a cohort of European Caucasian Systemic sclerosis patients do not support the implication of CDK6 gene in the pathogenesis of SSc but the gene were identified as Rheumatoid arthritis susceptibility gene.
      Title: Association study of 3 rheumatoid arthritis risk loci in systemic sclerosis in European Caucasian population.
    7. CDK6 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
      Title: The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
    8. Epigenetic regulation of the hsa-miR-124a microRNA (most frequently methylated in the acute lymphoblastic leukemia patients) mediates the increased expression of CDK6 and contributes to the abnormal proliferation of cells both in vitro and in vivo.
      Title: microRNA methylation profile has prognosis impact in acute lymphoblastic leukemia patients undergoing stem cell transplantation.
    9. Study elucidates a model to regulate glioma cell cycle progression in which hUCBSC acts to control cyclin D1 induction and in concert its partner kinases, Cdk 4 and Cdk 6 by mediating cell cycle arrest at G(0)-G(1) phase.
      Title: Regulation of glioblastoma progression by cord blood stem cells is mediated by downregulation of cyclin D1.
    10. p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer
      Title: Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer.
    Submit: New GeneRIF Correction See all (59)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Common variants at CD40 and other loci confer risk of rheumatoid arthritis.

    Genome-wide association analysis identifies 20 loci that influence adult height.

    Genome-wide association study of hematological and biochemical traits in a Japanese population.

    Genome-Wide Association Study of White Blood Cell Count in 16,388 African Americans: the Continental Origins and Genetic Epidemiology Network (COGENT)

    Identification of nine novel Loci associated with white blood cell subtypes in a Japanese population.

    Identification of ten loci associated with height highlights new biological pathways in human growth.

    Many sequence variants affecting diversity of adult human height.

    Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.

    Stature QTL 11

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001250.1 NP_444284.1 CCND1    BIND  PubMed CCND1 (cyclin D1) interacts with CDK6. 
    NP_001250.1 NP_001790.1 CDK7    BIND  PubMed CAK phosphorylates CDK6. This interaction was modeled on a demonstrated interaction between human CAK and CDK6 from an unspecified species. 
    NP_001250.1 AAR05391.1 CDKN2A    BIND  PubMed p16 interacts with cdk6. 
    NP_001250.1 NP_000068.1 CDKN2A    BIND  PubMed p16 interacts with cdk6. This interaction was modeled on a demonstrated interaction between human p16 and cdk6 from an unspecified species. 
    NP_001250.1 NP_000068.1 CDKN2A    BIND  PubMed p16 interacts with CDK6. This interaction was modeled on a demonstrated interaction between human p16 and CDK6 from an unspecified species. 
    NP_001250.1 NP_000068.1 CDKN2A    BIND  PubMed CDKN2A interacts with CDK6 
    NP_001250.1 CDKN2C    BIND  PubMed An unspecified isoform of p18 interacts with cdk6. This interaction was modeled on a demonstrated interaction between human p18 and cdk6 from an unspecified species. 
    NP_001250.1 NP_000312.1 RB1    BIND  PubMed Cdk6 phosphorylates Rb 
    NP_001250.1 NP_000312.1 RB1    BIND  PubMed CDK6 phosphorylates Rb. This interaction was modeled on a demonstrated interaction between CDK6 and Rb, both from an unspecified species. 
    NP_001250.1 NP_057864.1 tax    BIND  PubMed Tax interacts with CDK6. 
    Q00534 P10275 AR    HPRD  PubMed  
    Q00534 P54253 ATXN1    HPRD  PubMed  
    Q00534 P24385 CCND1    HPRD  PubMed  
    Q00534 P30279 CCND2    HPRD  PubMed  
    Q00534 P30281 CCND3    HPRD  PubMed  
    Q00534 Q16543 CDC37    HPRD  PubMed  
    Q00534 Q00534 CDK6    HPRD  PubMed  
    Q00534 P38936 CDKN1A    HPRD  PubMed  
    Q00534 Q8N726 CDKN2A    HPRD  PubMed  
    Q00534 P42773 CDKN2C    HPRD  PubMed  
    Q00534 P55273 CDKN2D    HPRD  PubMed  
    Q00534 Q9UIV1 CNOT7    HPRD  PubMed  
    Q00534 P35222 CTNNB1    HPRD  PubMed  
    Q00534 Q7L590 MCM10    HPRD  PubMed  
    Q00534 P49736 MCM2    HPRD  PubMed  
    Q00534 P12004 PCNA    HPRD  PubMed  
    Q00534 O75688 PPM1B    HPRD  PubMed  
    Q00534 P06400 RB1    HPRD  PubMed  
    Q00534 Q01196 RUNX1    HPRD  PubMed  
    Q00534 P36897 TGFBR1    HPRD  PubMed  
    BioGRID:107456 BioGRID:107067 CCND1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107456 BioGRID:107334 CCND2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107456 BioGRID:107336 CCND3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107456 BioGRID:116312 CDC37    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107456 BioGRID:107452 CDK2    BioGRID  PubMed Co-purification 
    BioGRID:107456 BioGRID:107460 CDKN1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107456 BioGRID:107461 CDKN1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107456 BioGRID:107463 CDKN2A    BioGRID  PubMed Affinity Capture-MS; Co-crystal Structure; Protein-peptide; Reconstituted Complex 
    BioGRID:107456 BioGRID:107465 CDKN2C    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:107456 BioGRID:107466 CDKN2D    BioGRID  PubMed Co-crystal Structure 
    BioGRID:107456 BioGRID:117326 FBXO7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107456 BioGRID:111490 PPM1B    BioGRID  PubMed Biochemical Activity; Co-purification 
    BioGRID:107456 BioGRID:111507 PPP2CA    BioGRID  PubMed Biochemical Activity; Co-purification 
    BioGRID:107456 BioGRID:113164 UBC    BioGRID  PubMed Co-purification 
    BioGRID:107456 BioGRID:125434 UHRF2    BioGRID  PubMed Far Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      C-MYB transcription factor network, organism-specific biosystem
      C-MYB transcription factor network
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Coregulation of Androgen receptor activity, organism-specific biosystem
      Coregulation of Androgen receptor activity
    • Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
      Cyclin D associated events in G1, organism-specific biosystemThree D-type cyclins are essential for progression from G1 to S-phase. These D cyclins bind to and activate both CDK4 and CDK6. The formation of all possible complexes between the D-type cyclins and...
    • G1 Phase, organism-specific biosystem (from REACTOME)
      G1 Phase, organism-specific biosystemEarly cell cycle progression in G1 is under the control of the D-type cyclins together with Cdk4 and Cdk6. An important target for these CDKs is the Retinoblastoma (Rb) protein, which when phosphoryl...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • IL2 signaling events mediated by STAT5, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by STAT5, organism-specific biosystem
      IL2 signaling events mediated by STAT5
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
      Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Non-small cell lung cancer, conserved biosystem (from KEGG)
      Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • miRNAs involved in DDR, organism-specific biosystem (from WikiPathways)
      miRNAs involved in DDR, organism-specific biosystemMicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    Clone Names

    • MGC59692

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cyclin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    cyclin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G1 phase of mitotic cell cycle IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    G1 phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    astrocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell cycle arrest TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell dedifferentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    dentate gyrus development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    generation of neurons ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    gliogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    lateral ventricle development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of cellular senescence IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to virus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    type B pancreatic cell development IDA
    Inferred from Direct Assay
    more info
    		  
    Component Evidence Code Pubs
    cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ruffle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    cyclin-dependent kinase 6
    Names
    cyclin-dependent kinase 6
    cell division protein kinase 6
    serine/threonine-protein kinase PLSTIRE
    NP_001138778.1
    NP_001250.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015888.1 RefSeqGene

      Range
      5001..236707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145306.1 → NP_001138778.1  cyclin-dependent kinase 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC000065, AC005156, AK313491, AW665776, BC027989, BC052264, BQ773638
      Consensus CDS
      CCDS5628.1
      UniProtKB/TrEMBL
      A4D1G0
      UniProtKB/Swiss-Prot
      Q00534
      Related
      ENSP00000397087, OTTHUMP00000208823, ENST00000424848, OTTHUMT00000342063
      Conserved Domains (2) summary
      cd07862
      Location:11 – 300
      Blast Score: 1458
      STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6
      PLN00009
      Location:11 – 304
      Blast Score: 750
      PLN00009; cyclin-dependent kinase A; Provisional

    2. NM_001259.6 → NP_001250.1  cyclin-dependent kinase 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC000065, AC005156, AI738486, BC027989, BC052264, BQ773638
      Consensus CDS
      CCDS5628.1
      UniProtKB/TrEMBL
      A4D1G0
      UniProtKB/Swiss-Prot
      Q00534
      Related
      ENSP00000265734, OTTHUMP00000162478, ENST00000265734, OTTHUMT00000254605
      Conserved Domains (2) summary
      cd07862
      Location:11 – 300
      Blast Score: 1458
      STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6
      PLN00009
      Location:11 – 304
      Blast Score: 750
      PLN00009; cyclin-dependent kinase A; Provisional

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      92234235..92465941, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      86843599..87075188, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      91563451..91795159, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC000065.1 None
    genomic AC004011.1 None
    genomic AC004128.1 None
    genomic AC005156.1 (71669..73698) None
    genomic AY128534.1 AAM76970.1
    genomic CH236949.1 EAL24146.1
    genomic CH471091.2 EAW76827.1
      EAW76828.1
      EAW76829.1
    mRNA AA312213.1 None
    mRNA AB073601.1 None
    mRNA AI023175.1 None
    mRNA AI367890.1 None
    mRNA AI400582.1 None
    mRNA AI738486.1 None
    mRNA AI935072.1 None
    mRNA AK000660.1 None
    mRNA AK055922.1 None
    mRNA AK123134.1 None
    mRNA AK172791.1 None
    mRNA AK313491.1 BAG36273.1
    mRNA AV726767.1 None
    mRNA AW665776.1 None
    mRNA BC012914.1 None
    mRNA BC027989.1 None
    mRNA BC052264.1 AAH52264.1
    mRNA BC063591.1 None
    mRNA BC065026.1 None
    mRNA BE893003.1 None
    mRNA BG166127.1 None
    mRNA BM542578.1 None
    mRNA BM542629.1 None
    mRNA BM542736.1 None
    mRNA BM905472.1 None
    mRNA BM978533.1 None
    mRNA BQ048881.1 None
    mRNA BQ213893.1 None
    mRNA BQ231384.1 None
    mRNA BQ773638.1 None
    mRNA BU159055.1 None
    mRNA X66365.1 CAA47008.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q00534.1 GenPept UniProtKB/Swiss-Prot:Q00534
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