Format

Send to:

Choose Destination

Arhgef18 rho/rac guanine nucleotide exchange factor (GEF) 18 [ Mus musculus (house mouse) ]

Gene ID: 102098, updated on 21-May-2016
Official Symbol
Arhgef18provided by MGI
Official Full Name
rho/rac guanine nucleotide exchange factor (GEF) 18provided by MGI
Primary source
MGI:MGI:2142567
See related
Ensembl:ENSMUSG00000004568 Vega:OTTMUSG00000030752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI467246; D030053O22Rik
Orthologs
Location:
8; 8 A1.1
Exon count:
22
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (3392943..3456601)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (3393008..3456600)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene insulin receptor Neighboring gene RIKEN cDNA A430078G23 gene Neighboring gene predicted gene, 30369 Neighboring gene RIKEN cDNA 1700019B03 gene Neighboring gene peroxisomal biogenesis factor 11 gamma

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
rho guanine nucleotide exchange factor 18

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133962.3NP_598723.3  rho guanine nucleotide exchange factor 18

    See identical proteins and their annotated locations for NP_598723.3

    Status: VALIDATED

    Source sequence(s)
    AK041423, BC060639, BM216300, BM935742, BQ830835, CA749983
    Consensus CDS
    CCDS22060.1
    UniProtKB/Swiss-Prot
    Q6P9R4
    Related
    ENSMUSP00000004684, OTTMUSP00000040024, ENSMUST00000004684, OTTMUST00000076126
    Conserved Domains (3) summary
    cd00160
    Location:102296
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam03938
    Location:712780
    OmpH; Outer membrane protein (OmpH-like)
    cd15794
    Location:337455
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    3392943..3456601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508682.1XP_006508745.1  

    See identical proteins and their annotated locations for XP_006508745.1

    Conserved Domains (3) summary
    cd00160
    Location:102296
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam03938
    Location:720788
    OmpH; Outer membrane protein (OmpH-like)
    cd15794
    Location:337455
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
  2. XM_011242035.1XP_011240337.1  

    See identical proteins and their annotated locations for XP_011240337.1

    Conserved Domains (3) summary
    cd00160
    Location:102296
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam03938
    Location:720788
    OmpH; Outer membrane protein (OmpH-like)
    cd15794
    Location:337455
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
  3. XM_006508681.2XP_006508744.1  

    See identical proteins and their annotated locations for XP_006508744.1

    Conserved Domains (3) summary
    cd00160
    Location:102296
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam03938
    Location:720788
    OmpH; Outer membrane protein (OmpH-like)
    cd15794
    Location:337455
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    3618863..3682398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)