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    EIF1 eukaryotic translation initiation factor 1 [ Homo sapiens ]

    Gene ID: 10209, updated on 11-May-2012
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    Summary

    Official Symbol
    EIF1provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 1provided by HGNC
    Primary source
    HGNC:3249
    See related
    Ensembl:ENSG00000173812; HPRD:15449; Vega:OTTHUMG00000133492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A121; ISO1; SUI1; EIF-1; EIF1A
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    Genomic context

    Location :
    17q21.2
    Sequence :
    Chromosome: 17; NC_000017.10 (39845127..39847898)
    See EIF1 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene keratin 17 Neighboring gene keratin 42 pseudogene Neighboring gene gastrin Neighboring gene huntingtin-associated protein 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (17) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. show that the stringency of start codon selection (preferential utilization of optimal start sites) is increased to a surprising degree by overexpressing eIF1
      Title: Initiation context modulates autoregulation of eukaryotic translation initiation factor 1 (eIF1).
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P41567 O95897 OLFM2    HPRD  PubMed  
    P41567 Q9HAU5 UPF2    HPRD  PubMed  
    BioGRID:115504 BioGRID:111583 MAPK6    BioGRID  PubMed Two-hybrid 
    BioGRID:115504 BioGRID:111856 RASA1    BioGRID  PubMed Two-hybrid 
    BioGRID:115504 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Translation Factors, organism-specific biosystem (from WikiPathways)
      Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    translation factor activity, nucleic acid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    translation initiation factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    regulation of translational initiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to stress NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    translational initiation NAS
    Non-traceable Author Statement
    more info
    		  
    translational initiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    eukaryotic translation initiation factor 1
    Names
    eukaryotic translation initiation factor 1
    sui1iso1
    protein translation factor SUI1 homolog
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005801.3 → NP_005792.1  eukaryotic translation initiation factor 1

      Status: VALIDATED

      Source sequence(s)
      AA159721, BC005118, BU165055
      Consensus CDS
      CCDS11403.1
      UniProtKB/Swiss-Prot
      P41567
      UniProtKB/TrEMBL
      Q6IAV3
      Related
      ENSP00000419449, OTTHUMP00000164728, ENST00000469257, OTTHUMT00000257390
      Conserved Domains (1) summary
      cd11566
      Location:29 – 112
      Blast Score: 348
      eIF1_SUI1; Eukaryotic initiation factor 1

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      39845127..39847898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      35607852..35610623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC130686.15 (21713..24484) None
    genomic CH471152.1 EAW60754.1
      EAW60755.1
    mRNA AA159721.1 None
    mRNA AF083441.1 AAD52028.1
    mRNA AF100737.1 AAD19900.1
    mRNA AJ012375.1 CAD66615.1
    mRNA AK311209.1 None
    mRNA AK311862.1 BAG34803.1
    mRNA AL050005.1 None
    mRNA BC005118.1 AAH05118.1
    mRNA BC008710.1 AAH08710.1
    mRNA BT006645.1 AAP35291.1
    mRNA BU165055.1 None
    mRNA CR457051.1 CAG33332.1
    mRNA L26247.1 AAA60602.1
    other-genetic DQ896700.2 ABM87699.1
    other-genetic EU176404.1 ABW03855.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41567.1 GenPept UniProtKB/Swiss-Prot:P41567
    Q6IAV3 GenPept UniProtKB/TrEMBL:Q6IAV3
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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