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Mbtps2 membrane bound transcription factor peptidase, site 2 [ Chinchilla lanigera (long-tailed chinchilla) ]

Gene ID: 102011027, updated on 10-Mar-2024

Summary

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Gene symbol
Mbtps2
Gene description
membrane bound transcription factor peptidase, site 2
See related
Ensembl:ENSCLAG00000001960
Gene type
protein coding
RefSeq status
MODEL
Organism
Chinchilla lanigera
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Chinchillidae; Chinchilla
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
11
Annotation release Status Assembly Chr Location
101 current ChiLan1.0 (GCF_000276665.1) Unplaced Scaffold NW_004955509.1 (2185054..2222497)

NW_004955509.1Genomic Context describing neighboring genes Neighboring gene kelch like family member 34 Neighboring gene uncharacterized LOC102009741 Neighboring gene small muscle protein X-linked Neighboring gene dnaJ homolog subfamily C member 21 pseudogene Neighboring gene archaemetzincin-2 pseudogene Neighboring gene spermine synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004955509.1 Unplaced Scaffold Reference ChiLan1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in membrane protein intracellular domain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
membrane-bound transcription factor site-2 protease

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Chinchilla lanigera Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ChiLan1.0 Primary Assembly

Genomic

  1. NW_004955509.1 Reference ChiLan1.0 Primary Assembly

    Range
    2185054..2222497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005407825.2 → XP_005407882.1  membrane-bound transcription factor site-2 protease

    UniProtKB/TrEMBL
    A0A8C2UQ89
    Related
    ENSCLAP00000002714.1, ENSCLAT00000002770.1
    Conserved Domains (3) summary
    cd05709
    Location:464 → 553
    S2P-M50; Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic ...
    cd06162
    Location:50 → 274
    S2P-M50_PDZ_SREBP; Sterol regulatory element-binding protein (SREBP) Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50A), regulates intramembrane proteolysis (RIP) of SREBP and is part of a signal transduction mechanism involved in sterol and lipid ...
    cl00117
    Location:300 → 340
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
Nucleotide Protein
Heading Accession and Version

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