CDK5 cyclin-dependent kinase 5 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: CDK5provided by HGNC
Official Full Name: cyclin-dependent kinase 5provided by HGNC
Primary source: HGNC:1774
See related: Ensembl:ENSG00000164885; HPRD:00449; MIM:123831; Vega:OTTHUMG00000158414
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PSSALRE

Help top of page

Genomic context

Location :: 7q36

Sequence :: Chromosome: 7; NC_000007.13 (150750899..150755052, complement)

See CDK5 in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Activation of transgenic c-Abl by amyloidbeta precursor protein promotes tau phosphorylation through Tyr15 phosphorylation-mediated cyclin-dependent protein kinase 5 (Cdk5) activation.
Title: c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice.
HtrA2 and Cdk5 interact in human and mouse cell lines and brain.
Title: Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.
Abeta42 may increase the BACE1 level independently of either Cdk5 or caspase 3 and that Cdk5 inhibition for AD may cause BACE1 elevation, a potentially negative therapeutic outcome.
Title: Cdk5 protein inhibition and Aβ42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease.
suggesting that the enhanced radiation sensitivity of Cdk5(KD) cells is due to a role of Cdk5 in other pathways or the altered polymer levels
Title: The impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiation.
novel roles for Cdk5 outside of the nervous system have been proposed, including roles in gene transcription, vesicular transport, apoptosis, cell adhesion, and migration in many cell types and tissues
Title: Going out of the brain: non-nervous system physiological and pathological functions of Cdk5.
These findings demonstrate the distinct involvement of Cdk5 in GTP- and fMLP-induced secretion by neutrophils, and support the notion that specific targeting of Cdk5 may serve to inhibit the neutrophil secretory process.
Title: Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils.
These results suggest that mutant K-Ras acts in concert with CDK5 and its activators to increase malignant progression, migration, and invasion of pancreatic cancer cells.
Title: Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras.
CDK5/p35 may represent a biomarker for prognosis in patients with non-small cell lung cancer
Title: Expression of CDK5/p35 in resected patients with non-small cell lung cancer: relation to prognosis.
Cdk5: mediator of neuronal development, death and the response to DNA damage.
Title: Cdk5: mediator of neuronal development, death and the response to DNA damage.
Cdk5 plays a crucial role in inflammation-induced nociception. (Review)
Title: Twice switched at birth: cell cycle-independent roles of the "neuron-specific" cyclin-dependent kinase 5 (Cdk5) in non-neuronal cells.

Submit: New GeneRIF Correction See all (83)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat downregulates the expression of p35, a neuron-specific activator of cdk5, and also binds to Puralpha, which associates with cdk5, leading to deregulation of neuronal differentiation and survival	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
NP_004926.1	NP_003876.1	CDK5R1	BIND	PubMed	p35 interacts with Cdk5. This interaction was modeled on a demonstrated interaction between bovine p35 and human Cdk5.
NP_004926.1	NP_003876.1	CDK5R1	BIND	PubMed	Cdk5 interacts with p35.
Q00535	P00519	ABL1	HPRD	PubMed
Q00535	P12814	ACTN1	HPRD	PubMed
Q00535	P49418	AMPH	HPRD	PubMed
Q00535	P05067	APP	HPRD	PubMed
Q00535	CROC4	C1orf61	HPRD	PubMed
Q00535	Q8TDN4	CABLES1	HPRD	PubMed
Q00535	Q9BTV7	CABLES2	HPRD	PubMed
Q00535	P30279	CCND2	HPRD	PubMed
Q00535	P51959	CCNG1	HPRD	PubMed
Q00535	Q16543	CDC37	HPRD	PubMed
Q00535	Q00536	CDK16	HPRD	PubMed
Q00535	Q00535	CDK5	HPRD	PubMed
Q00535	Q15078	CDK5R1	HPRD	PubMed
Q00535	Q13319	CDK5R2	HPRD	PubMed
Q00535	Q96SZ6	CDK5RAP1	HPRD	PubMed
Q00535	P46527	CDKN1B	HPRD	PubMed
Q00535	P15882	CHN1	HPRD	PubMed
Q00535	P48730	CSNK1D	HPRD	PubMed
Q00535	O75553	DAB1	HPRD	PubMed
Q00535	O43602	DCX	HPRD	PubMed
Q00535	Q05193	DNM1	HPRD	PubMed
Q00535	P21860	ERBB3	HPRD	PubMed
Q00535	P15311	EZR	HPRD	PubMed
Q00535	Fibronectin type III and SPRY domain containing 1	FSD1	HPRD	PubMed
Q00535	P06241	FYN	HPRD	PubMed
Q00535	O14976	GAK	HPRD	PubMed
Q00535	Q12879	GRIN2A	HPRD	PubMed
Q00535	P49841	GSK3B	HPRD	PubMed
Q00535	Q02750	MAP2K1	HPRD	PubMed
Q00535	P53779	MAPK10	HPRD	PubMed
Q00535	P10636	MAPT	HPRD	PubMed
Q00535	P10636	MAPT	HPRD	PubMed
Q00535	P10636	MAPT	HPRD	PubMed
Q00535	Q02078	MEF2A	HPRD	PubMed
Q00535	Q9GZM8	NDEL1	HPRD	PubMed
Q00535	P48681	NES	HPRD	PubMed
Q00535	Q13153	PAK1	HPRD	PubMed
Q00535	P12004	PCNA	HPRD	PubMed
Q00535	O60331	PIP5K1C	HPRD	PubMed
Q00535	Q9UD71	PPP1R1B	HPRD	PubMed
Q00535	P41236	PPP1R2	HPRD	PubMed
Q00535	P49768	PSEN1	HPRD	PubMed
Q00535	P17706	PTPN2	HPRD	PubMed
Q00535	Q00577	PURA	HPRD	PubMed
Q00535	Q01105	SET	HPRD	PubMed
Q00535	P12931	SRC	HPRD	PubMed
Q00535	Q16623	STX1A	HPRD	PubMed
Q00535	P61764	STXBP1	HPRD	PubMed
Q00535	P17600	SYN1	HPRD	PubMed
Q00535	O43426	SYNJ1	HPRD	PubMed
Q00535	P04637	TP53	HPRD	PubMed
Q00535	Q92558	WASF1	HPRD	PubMed
BioGRID:107455	BioGRID:106713	ALAS1	BioGRID	PubMed	Two-hybrid
BioGRID:107455	BioGRID:113647	BAG6	BioGRID	PubMed	Two-hybrid
BioGRID:107455	BioGRID:107140	BRCA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107455	BioGRID:123628	CABLES2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107455	BioGRID:107334	CCND2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107455	BioGRID:111154	CDK16	BioGRID	PubMed	Biochemical Activity
BioGRID:107455	BioGRID:114376	CDK5R1	BioGRID	PubMed	Affinity Capture-Western; Co-crystal Structure
BioGRID:107455	BioGRID:120873	CDK5RAP2	BioGRID	PubMed	Reconstituted Complex
BioGRID:107455	BioGRID:198624	Cdk1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107455	BioGRID:108853	GAK	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107455	BioGRID:115106	HDAC4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107455	BioGRID:116524	LMTK2	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:107455	BioGRID:123527	NDEL1	BioGRID	PubMed	Biochemical Activity; Co-localization
BioGRID:107455	BioGRID:110811	NEDD4	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:107455	BioGRID:116915	NEDD4L	BioGRID	PubMed	Biochemical Activity
BioGRID:107455	BioGRID:115983	NES	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107455	BioGRID:247522	Nedd4	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:107455	BioGRID:111095	PAK1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107455	BioGRID:111105	PARK2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107455	BioGRID:111142	PCNA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107455	BioGRID:112676	STX1A	BioGRID	PubMed	Reconstituted Complex
BioGRID:107455	BioGRID:112681	STXBP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107455	BioGRID:215053	Suds3	BioGRID	PubMed	Biochemical Activity
BioGRID:107455	BioGRID:112949	TLN1	BioGRID	PubMed	Biochemical Activity
BioGRID:107455	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107455	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
ErbB-2 class receptor binding	ISS Inferred from Sequence or Structural Similarity more info
ErbB-3 class receptor binding	ISS Inferred from Sequence or Structural Similarity more info
acetylcholine receptor activator activity	ISS Inferred from Sequence or Structural Similarity more info
cyclin-dependent protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
kinase activity	ISS Inferred from Sequence or Structural Similarity more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
p53 binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info
protein kinase activity	TAS Traceable Author Statement more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info
protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
protein serine/threonine kinase activity	TAS Traceable Author Statement more info
tau-protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
Schwann cell development	IEA Inferred from Electronic Annotation more info
activation of pro-apoptotic gene products	IDA Inferred from Direct Assay more info
axon extension	TAS Traceable Author Statement more info
axon guidance	TAS Traceable Author Statement more info
behavioral response to cocaine	IEA Inferred from Electronic Annotation more info
blood coagulation	TAS Traceable Author Statement more info
cell cycle	ISS Inferred from Sequence or Structural Similarity more info
cell cycle	TAS Traceable Author Statement more info	PubMed
cell death	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
cell proliferation	TAS Traceable Author Statement more info	PubMed
cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
central nervous system neuron development	IEA Inferred from Electronic Annotation more info
cerebellar cortex development	IEA Inferred from Electronic Annotation more info
cerebellar cortex formation	IEA Inferred from Electronic Annotation more info
cerebral cortex development	IEA Inferred from Electronic Annotation more info
corpus callosum development	IEA Inferred from Electronic Annotation more info
cortical actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
embryo development	ISS Inferred from Sequence or Structural Similarity more info
hippocampus development	IEA Inferred from Electronic Annotation more info
intracellular protein transport	IEA Inferred from Electronic Annotation more info
layer formation in cerebral cortex	IEA Inferred from Electronic Annotation more info
motor axon guidance	IEA Inferred from Electronic Annotation more info
negative regulation of cell cycle	IEA Inferred from Electronic Annotation more info
negative regulation of protein export from nucleus	IEA Inferred from Electronic Annotation more info
negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
negative regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
negative regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info
neuron apoptosis	TAS Traceable Author Statement more info
neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
neuron differentiation	TAS Traceable Author Statement more info
neuron migration	TAS Traceable Author Statement more info
neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
oligodendrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info
phosphorylation	IDA Inferred from Direct Assay more info
phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of actin cytoskeleton reorganization	TAS Traceable Author Statement more info
positive regulation of calcium ion-dependent exocytosis	IEA Inferred from Electronic Annotation more info
positive regulation of neuron apoptosis	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of protein kinase activity	IEA Inferred from Electronic Annotation more info
positive regulation of receptor activity	IEA Inferred from Electronic Annotation more info
protein autophosphorylation	IEA Inferred from Electronic Annotation more info
protein phosphorylation	TAS Traceable Author Statement more info	PubMed
receptor catabolic process	IEA Inferred from Electronic Annotation more info
receptor clustering	IEA Inferred from Electronic Annotation more info
regulated secretory pathway	IEA Inferred from Electronic Annotation more info
regulation of apoptotic process	TAS Traceable Author Statement more info
regulation of cell cycle arrest	TAS Traceable Author Statement more info
regulation of cell migration	IEA Inferred from Electronic Annotation more info
regulation of dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
regulation of excitatory postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
regulation of synaptic plasticity	TAS Traceable Author Statement more info
response to wounding	IEA Inferred from Electronic Annotation more info
sensory perception of pain	IEA Inferred from Electronic Annotation more info
serine phosphorylation of STAT3 protein	IEA Inferred from Electronic Annotation more info
skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
synapse assembly	TAS Traceable Author Statement more info
synaptic transmission	TAS Traceable Author Statement more info
synaptic transmission, dopaminergic	IEA Inferred from Electronic Annotation more info
synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
synaptic vesicle endocytosis	TAS Traceable Author Statement more info
synaptic vesicle exocytosis	TAS Traceable Author Statement more info
visual learning	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
axon	ISS Inferred from Sequence or Structural Similarity more info
cell junction	IEA Inferred from Electronic Annotation more info
cyclin-dependent protein kinase 5 holoenzyme complex	IEA Inferred from Electronic Annotation more info
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
dendrite	ISS Inferred from Sequence or Structural Similarity more info
filopodium	IEA Inferred from Electronic Annotation more info
growth cone	ISS Inferred from Sequence or Structural Similarity more info
lamellipodium	IEA Inferred from Electronic Annotation more info
membrane	ISS Inferred from Sequence or Structural Similarity more info
neuromuscular junction	ISS Inferred from Sequence or Structural Similarity more info
neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
nuclear part	IEA Inferred from Electronic Annotation more info
nucleus	ISS Inferred from Sequence or Structural Similarity more info
perikaryon	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info
postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
postsynaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: cyclin-dependent kinase 5

Names: cyclin-dependent kinase 5; TPKII catalytic subunit; protein kinase CDK5 splicing; cell division protein kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit

NP_001157882.1

EC 2.7.11.22

NP_004926.1

EC 2.7.11.22

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164410.1 → NP_001157882.1 cyclin-dependent kinase 5 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2), also known as CDK5-SV, omits an in-frame coding exon compared to variant 1 resulting in a shorter predicted protein (isoform 2). Expression of this transcript was described by Li et al. (2009; PubMed ID 19693690).

Source sequence(s)

AC010973, BC005115, BP309068, CB114175, DB487008, DQ411039

Consensus CDS

CCDS55184.1

UniProtKB/Swiss-Prot

Q00535

Related

ENSP00000297518, OTTHUMP00000212939, ENST00000297518, OTTHUMT00000351034

Conserved Domains (2) summary

PLN00009
Location:1 – 256
Blast Score: 871

PLN00009; cyclin-dependent kinase A; Provisional

cl09925
Location:3 – 254
Blast Score: 1363

PKc_like; Protein Kinases, catalytic domain
NM_004935.3 → NP_004926.1 cyclin-dependent kinase 5 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

AC010973, AK026533, BC005115, BP309068, CA429180, DB487008

Consensus CDS

CCDS47748.1

UniProtKB/Swiss-Prot

Q00535

Related

ENSP00000419782, OTTHUMP00000212917, ENST00000485972, OTTHUMT00000350965

Conserved Domains (2) summary

cd07839
Location:3 – 286
Blast Score: 1579

STKc_CDK5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5

PLN00009
Location:1 – 288
Blast Score: 1057

PLN00009; cyclin-dependent kinase A; Provisional

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p5 Primary Assembly

Range

150750899..150755052, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

144563235..144567388, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

150080438..150084591, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AACC02000108.1	EAL24498.1
genomic	AC010973.6 (147786..151883)	None
genomic	CH471173.2	EAW54049.1
		EAW54050.1
		EAW54051.1
mRNA	AK026533.1	None
mRNA	AY049778.1	AAL15435.1
mRNA	AY927560.1	None
mRNA	BC005115.1	AAH05115.1
mRNA	BP309068.1	None
mRNA	BT006680.1	AAP35326.1
mRNA	BU527089.1	None
mRNA	CA429180.1	None
mRNA	CB114175.1	None
mRNA	CR457041.1	CAG33322.1
mRNA	DB487008.1	None
mRNA	DQ411039.1	ABD66016.1
mRNA	L04658.1	None
mRNA	X66364.1	CAA47007.1