U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

F12 coagulation factor XII [ Microtus ochrogaster (prairie vole) ]

Gene ID: 101999162, updated on 8-Mar-2024

Summary

Go to the top of the page Help
Gene symbol
F12
Gene description
coagulation factor XII
See related
Ensembl:ENSMOCG00000001174
Gene type
protein coding
RefSeq status
MODEL
Organism
Microtus ochrogaster
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Arvicolinae; Microtus
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 16
Exon count:
14
Annotation release Status Assembly Chr Location
102 current MicOch1.0 (GCF_000317375.1) 16 NC_022018.1 (56320366..56327991, complement)

Chromosome 16 - NC_022018.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 34 member 1 Neighboring gene profilin 3 Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene proline rich 7, synaptic

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_022018.1 Chromosome 16 Reference MicOch1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in zymogen activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
coagulation factor XII

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Microtus ochrogaster Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference MicOch1.0

Genomic

  1. NC_022018.1 Reference MicOch1.0

    Range
    56320366..56327991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005355238.1 → XP_005355295.1  coagulation factor XII

    UniProtKB/TrEMBL
    A0A8J6G5N5
    Related
    ENSMOCP00000001554.1, ENSMOCT00000001616.1
    Conserved Domains (7) summary
    smart00020
    Location:366 → 603
    Tryp_SPc; Trypsin-like serine protease
    cd00054
    Location:95 → 130
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00061
    Location:132 → 172
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00190
    Location:367 → 606
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00008
    Location:177 → 207
    EGF; EGF-like domain
    pfam00040
    Location:47 → 87
    fn2; Fibronectin type II domain
    pfam00051
    Location:216 → 294
    Kringle; Kringle domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.