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TNK2 tyrosine kinase non receptor 2 [ Homo sapiens (human) ]

Gene ID: 10188, updated on 26-May-2016
Official Symbol
TNK2provided by HGNC
Official Full Name
tyrosine kinase non receptor 2provided by HGNC
Primary source
HGNC:HGNC:19297
See related
Ensembl:ENSG00000061938 HPRD:06104; MIM:606994; Vega:OTTHUMG00000155737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACK; ACK1; ACK-1; p21cdc42Hs
Summary
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Orthologs
Location:
3q29
Exon count:
22
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (195863364..195909009, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195590235..195635880, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene proline-rich protein 36-like Neighboring gene uncharacterized LOC101929697 Neighboring gene kinesin family member 3A pseudogene Neighboring gene microRNA 6829 Neighboring gene serine/threonine-protein phosphatase 4 regulatory subunit 2-like Neighboring gene mucin-5AC-like Neighboring gene succinate dehydrogenase complex flavoprotein subunit A pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    CDC42 signaling events, organism-specific biosystem
    CDC42 signaling events
  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ44758, FLJ45547

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
WW domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
epidermal growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of clathrin-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
Grb2-EGFR complex IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
coated pit IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
activated CDC42 kinase 1
Names
activated Cdc42-associated kinase 1
activated p21cdc42Hs kinase
tyrosine kinase non-receptor protein 2
tyrosine kinase, non-receptor, 2
NP_001010938.1
NP_005772.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029779.1 RefSeqGene

    Range
    5001..50645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001010938.1NP_001010938.1  activated CDC42 kinase 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a distinct 5' UTR and 5' coding region, lacks one alternate 3' coding exon, and contains a different alternate 3' coding exon, as compared to variant 1. The translation remains in-frame, and results in a longer isoform (2) that has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK131539, BE676668, BG742978
    Consensus CDS
    CCDS33927.1
    UniProtKB/Swiss-Prot
    Q07912
    Related
    ENSP00000371341, OTTHUMP00000208565, ENST00000381916, OTTHUMT00000341440
    Conserved Domains (7) summary
    pfam09027
    Location:510577
    GTPase_binding; GTPase binding
    pfam11555
    Location:852919
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:69130
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:189448
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:458507
    SH3_9; Variant SH3 domain
    cd14328
    Location:10371076
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:193450
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  2. NM_001308046.1NP_001294975.1  activated CDC42 kinase 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate 5' exon, contains an alternate 5' terminal exon, lacks one alternate 3' coding exon, and initiates translation at an alternate start codon, compared to variant 1. It encodes a shorter isoform (3) that has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC124944, AK131539, AK225786, BC020389, BG742978, L13738
    Consensus CDS
    CCDS77875.1
    UniProtKB/Swiss-Prot
    Q07912
    UniProtKB/TrEMBL
    C9J1X3
    Conserved Domains (7) summary
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806873
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:158417
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
    cd14328
    Location:9911030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  3. NM_005781.4NP_005772.3  activated CDC42 kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_005772.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the more frequently occurring transcript and it encodes isoform 1.
    Source sequence(s)
    AK127455, AK131539, BG742978, CN411136, L13738
    Consensus CDS
    CCDS33928.1
    UniProtKB/Swiss-Prot
    Q07912
    UniProtKB/TrEMBL
    B3KXJ4
    Related
    ENSP00000329425, OTTHUMP00000208563, ENST00000333602, OTTHUMT00000341437
    Conserved Domains (8) summary
    pfam09027
    Location:447514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774841
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:126385
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
    cd14274
    Location:9581002
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:9891028
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    195863364..195909009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269270.3XP_005269327.1  

    See identical proteins and their annotated locations for XP_005269327.1

    Conserved Domains (8) summary
    pfam09027
    Location:447514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789856
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:126385
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
    cd14274
    Location:9761019
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10061045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  2. XM_011512320.1XP_011510622.1  

    See identical proteins and their annotated locations for XP_011510622.1

    Conserved Domains (8) summary
    pfam09027
    Location:447514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789856
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:126385
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
    cd14274
    Location:9761019
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10061045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  3. XM_011512317.1XP_011510619.1  

    Conserved Domains (8) summary
    pfam09027
    Location:611678
    GTPase_binding; GTPase binding
    pfam11555
    Location:9531020
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:170231
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:290549
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:559608
    SH3_9; Variant SH3 domain
    cd14274
    Location:11401183
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:11701209
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:294551
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  4. XM_005269268.3XP_005269325.1  

    Conserved Domains (8) summary
    pfam09027
    Location:510577
    GTPase_binding; GTPase binding
    pfam11555
    Location:852919
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:69130
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:189448
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:458507
    SH3_9; Variant SH3 domain
    cd14274
    Location:10391082
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10691108
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:193450
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  5. XM_005269275.3XP_005269332.1  

    Related
    ENSP00000398614, OTTHUMP00000208567, ENST00000416152, OTTHUMT00000341445
    Conserved Domains (6) summary
    pfam09027
    Location:133200
    GTPase_binding; GTPase binding
    pfam11555
    Location:475542
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:81130
    SH3_9; Variant SH3 domain
    cd14274
    Location:662705
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:692731
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cl21453
    Location:173
    PKc_like; Protein Kinases, catalytic domain
  6. XM_005269272.3XP_005269329.1  

    Related
    ENSP00000392546, OTTHUMP00000208566, ENST00000428187, OTTHUMT00000341442
    Conserved Domains (7) summary
    pfam09027
    Location:479546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806873
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:3899
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:158417
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:427476
    SH3_9; Variant SH3 domain
    cd14328
    Location:9911030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  7. XM_011512319.1XP_011510621.1  

    See identical proteins and their annotated locations for XP_011510621.1

    Conserved Domains (8) summary
    pfam09027
    Location:447514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774841
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:126385
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
    cd14274
    Location:9611004
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:9911030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  8. XM_011512318.1XP_011510620.1  

    Conserved Domains (8) summary
    pfam09027
    Location:447514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789856
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:126385
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:395444
    SH3_9; Variant SH3 domain
    cd14274
    Location:9731017
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:10041043
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  9. XM_011512321.1XP_011510623.1  

    Conserved Domains (7) summary
    pfam09027
    Location:371438
    GTPase_binding; GTPase binding
    pfam11555
    Location:713780
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    smart00221
    Location:50309
    STYKc; Protein kinase; unclassified specificity
    pfam14604
    Location:319368
    SH3_9; Variant SH3 domain
    cd14274
    Location:900943
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:930969
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:54311
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
  10. XM_005269274.3XP_005269331.1  

    Conserved Domains (6) summary
    pfam09027
    Location:208275
    GTPase_binding; GTPase binding
    pfam11555
    Location:550617
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:156205
    SH3_9; Variant SH3 domain
    cd14274
    Location:737780
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:767806
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cl21453
    Location:1148
    PKc_like; Protein Kinases, catalytic domain

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    195555272..195606419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)