CDK3 cyclin-dependent kinase 3 [Homo sapiens] - Gene

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Summary

Official Symbol: CDK3provided by HGNC
Official Full Name: cyclin-dependent kinase 3provided by HGNC
Primary source: HGNC:1772
See related: Ensembl:ENSG00000250506; HPRD:00446; MIM:123828; Vega:OTTHUMG00000154861
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 17q22-qter

Sequence :: Chromosome: 17; NC_000017.10 (73996987..74002080)

See CDK3 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The Walleye dermal sarcoma virus cyclin functions as a structural ortholog of cyclin C in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 and Cdk3.
Title: The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8.
Expression level of cdk3 is higher in human cancer cell lines and glioblastoma tissue compared with normal brain tissue. cdk3 phosphorylates activating transcription factor 1 (ATF1)and enhances the transactivation and transcriptional activities of ATF1.
Title: Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation.
A non-cdk8-associated cellular pool of cyclin C combines with cdk3 to stimulate pRb phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently.
Title: Cyclin C/cdk3 promotes Rb-dependent G0 exit.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001249.1	NP_005181.1	CCNC	BIND	PubMed	Cyclin C interacts with Cdk3.
Q00526	Q8TDN4	CABLES1	HPRD	PubMed
Q00526	Q9BTV7	CABLES2	HPRD	PubMed
Q00526	P20248	CCNA2	HPRD	PubMed
Q00526	P24863	CCNC	HPRD	PubMed
Q00526	P24864	CCNE1	HPRD	PubMed
Q00526	O96020	CCNE2	HPRD	PubMed
Q00526	Q16543	CDC37	HPRD	PubMed
Q00526	Q00526	CDK3	HPRD	PubMed
Q00526	P38936	CDKN1A	HPRD	PubMed
Q00526	P46527	CDKN1B	HPRD	PubMed
Q00526	Q16667	CDKN3	HPRD	PubMed
Q00526	Q01094	E2F1	HPRD	PubMed
Q00526	Q14209	E2F2	HPRD	PubMed
Q00526	O00716	E2F3	HPRD	PubMed
Q00526	P43629	KIR3DL1	HPRD	PubMed
BioGRID:107453	BioGRID:123628	CABLES2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107453	BioGRID:111596	EIF2AK2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107453	BioGRID:116915	NEDD4L	BioGRID	PubMed	Reconstituted Complex
BioGRID:107453	BioGRID:112885	TFDP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107453	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
cyclin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G0 to G1 transition	TAS Traceable Author Statement more info	PubMed
G1/S transition of mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
cell division	IEA Inferred from Electronic Annotation more info
cell proliferation	TAS Traceable Author Statement more info	PubMed
mitosis	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: cyclin-dependent kinase 3

Names: cyclin-dependent kinase 3; cell division protein kinase 3

NP_001249.1

EC 2.7.11.22

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001258.2 → NP_001249.1 cyclin-dependent kinase 3

Status: VALIDATED

Source sequence(s)

AU146328, BU784937, BX098771, DB455174, X66357

Consensus CDS

CCDS11736.1

UniProtKB/Swiss-Prot

Q00526

Related

ENSP00000400088, ENST00000448471

Conserved Domains (2) summary

cd07860
Location:3 – 286
Blast Score: 1526

STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

PLN00009
Location:1 – 293
Blast Score: 1240

PLN00009; cyclin-dependent kinase A; Provisional

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

73996987..74002080

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

69422590..69427691

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC040980.14 (67516..72609)	None
genomic	AY789470.1	AAV40830.1
genomic	CH471099.1	EAW89353.1
		EAW89354.1
		EAW89355.1
mRNA	AU146328.1	None
mRNA	BC128406.1	None
mRNA	BU784937.1	None
mRNA	BX098771.1	None
mRNA	DB455174.1	None
mRNA	X66357.1	CAA47001.1
other-genetic	BC160074.1	AAI60074.1