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    CDK3 cyclin-dependent kinase 3 [ Homo sapiens (human) ]

    Gene ID: 1018, updated on 5-May-2013
    Official Symbol
    CDK3provided by HGNC
    Official Full Name
    cyclin-dependent kinase 3provided by HGNC
    Primary source
    HGNC:1772
    See related
    Ensembl:ENSG00000250506; HPRD:00446; MIM:123828; Vega:OTTHUMG00000154861
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]
    Location :
    17q25.1
    Sequence :
    Chromosome: 17; NC_000017.10 (73996987..74002080)
    See CDK3 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene Fas (TNFRSF6) binding factor 1 Neighboring gene acyl-CoA oxidase 1, palmitoyl Neighboring gene TEN1-CDK3 readthrough (NMD candidate) Neighboring gene TEN1 telomerase capping complex subunit homolog (S. cerevisiae) Neighboring gene envoplakin Neighboring gene signal recognition particle 68kDa

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale M, et al. Cell, 2012 Aug 31. PMID 22939624.
    2. Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase. Zhang J, et al. J Biol Chem, 2012 Jul 27. PMID 22654103.
    3. Toward an understanding of the protein interaction network of the human liver. Wang J, et al. Mol Syst Biol, 2011 Oct 11. PMID 21988832.
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422.

    See all (35) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The Walleye dermal sarcoma virus cyclin functions as a structural ortholog of cyclin C in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 and Cdk3.
      Title: The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8.
    2. Expression level of cdk3 is higher in human cancer cell lines and glioblastoma tissue compared with normal brain tissue. cdk3 phosphorylates activating transcription factor 1 (ATF1)and enhances the transactivation and transcriptional activities of ATF1.
      Title: Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation.
    3. A non-cdk8-associated cellular pool of cyclin C combines with cdk3 to stimulate pRb phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently.
      Title: Cyclin C/cdk3 promotes Rb-dependent G0 exit.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001249.1 NP_005181.1 CCNC    BIND  PubMed Cyclin C interacts with Cdk3. 
    Q00526 Q8TDN4 CABLES1    HPRD  PubMed  
    Q00526 Q9BTV7 CABLES2    HPRD  PubMed  
    Q00526 P20248 CCNA2    HPRD  PubMed  
    Q00526 P24863 CCNC    HPRD  PubMed  
    Q00526 P24864 CCNE1    HPRD  PubMed  
    Q00526 O96020 CCNE2    HPRD  PubMed  
    Q00526 Q16543 CDC37    HPRD  PubMed  
    Q00526 Q00526 CDK3    HPRD  PubMed  
    Q00526 P38936 CDKN1A    HPRD  PubMed  
    Q00526 P46527 CDKN1B    HPRD  PubMed  
    Q00526 Q16667 CDKN3    HPRD  PubMed  
    Q00526 Q01094 E2F1    HPRD  PubMed  
    Q00526 Q14209 E2F2    HPRD  PubMed  
    Q00526 O00716 E2F3    HPRD  PubMed  
    Q00526 P43629 KIR3DL1    HPRD  PubMed  
    BioGRID:107453 BioGRID:106848 APP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107453 BioGRID:106902 ARRB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107453 BioGRID:123628 CABLES2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107453 BioGRID:114582 CCNE2    BioGRID  PubMed Two-hybrid 
    BioGRID:107453 BioGRID:114376 CDK5R1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107453 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107453 BioGRID:116176 COPS6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107453 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107453 BioGRID:250420 Cdkn1a    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107453 BioGRID:249757 Cdkn1b    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107453 BioGRID:111596 EIF2AK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107453 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107453 BioGRID:116915 NEDD4L    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107453 BioGRID:111461 PPARA    BioGRID  PubMed Two-hybrid 
    BioGRID:107453 BioGRID:111860 RB1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107453 BioGRID:112885 TFDP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107453 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 

    Markers

    Genotypes

    Readthrough TEN1-CDK3

    Readthrough gene: TEN1-CDK3, Included gene: TEN1

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    G0 to G1 transition TAS
    Traceable Author Statement
    more info
    		 PubMed 
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    cyclin-dependent kinase 3
    Names
    cyclin-dependent kinase 3
    cell division protein kinase 3
    NP_001249.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258.2 → NP_001249.1  cyclin-dependent kinase 3

      Status: VALIDATED

      Source sequence(s)
      AU146328, BU784937, BX098771, DB455174, X66357
      Consensus CDS
      CCDS11736.1
      UniProtKB/Swiss-Prot
      Q00526
      Related
      ENSP00000400088, ENST00000448471
      Conserved Domains (2) summary
      cd07860
      Location:3 – 286
      Blast Score: 1526
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3
      PLN00009
      Location:1 – 293
      Blast Score: 1240
      PLN00009; cyclin-dependent kinase A; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p10 Primary Assembly

      Range
      73996987..74002080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      69422590..69427691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018928.1 Alternate CHM1_1.0

      Range
      75080518..75085611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01028762.1 (49196..54297) None
    genomic AC040980.14 (67517..72610) None
    genomic AMYH01008636.1 (32470..37563) None
    genomic AY789470.1 AAV40830.1
    genomic CH471099.1 EAW89353.1
      EAW89354.1
      EAW89355.1
    mRNA AU146328.1 None
    mRNA BC128406.1 None
    mRNA BU784937.1 None
    mRNA BX098771.1 None
    mRNA DB455174.1 None
    mRNA X66357.1 CAA47001.1
    other-genetic BC160074.1 AAI60074.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00526.1 GenPept UniProtKB/Swiss-Prot:Q00526

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioAssay, by Protein Target
        BioAssay, by Protein Target
      • BioAssays, RNAi Target,Active
        BioAssays, RNAi Target,Active
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

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