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ARHGAP12 Rho GTPase activating protein 12 [ Anas platyrhynchos (mallard) ]

Gene ID: 101790695, updated on 8-Mar-2024

Summary

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Gene symbol
ARHGAP12
Gene description
Rho GTPase activating protein 12
Locus tag
Anapl_11136
See related
EnsemblRapid:ENSAPLG00030021086
Gene type
protein coding
RefSeq status
MODEL
Organism
Anas platyrhynchos
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; Anatinae; Anas
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
23
Annotation release Status Assembly Chr Location
104 current ZJU1.0 (GCF_015476345.1) 2 NC_051773.1 (149030985..149108816, complement)
103 previous assembly IASCAAS_PekingDuck_PBH1.5 (GCF_003850225.1) 2 NC_040047.1 (15033879..15111590)

Chromosome 2 - NC_051773.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119716131 Neighboring gene zinc finger E-box binding homeobox 1 Neighboring gene kinesin family member 5B Neighboring gene uncharacterized LOC106019628 Neighboring gene enhancer of polycomb homolog 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho GTPase-activating protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Anas platyrhynchos Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ZJU1.0 Primary Assembly

Genomic

  1. NC_051773.1 Reference ZJU1.0 Primary Assembly

    Range
    149030985..149108816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038174314.1 → XP_038030242.1  rho GTPase-activating protein 12 isoform X7

    UniProtKB/TrEMBL
    A0A493T1C5, A0A8B9ZE55
    Related
    ENSAPLP00030035420.1, ENSAPLT00030055147.1
    Conserved Domains (6) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    COG5104
    Location:265 → 360
    PRP40; Splicing factor [RNA processing and modification]
    cd00201
    Location:263 → 293
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:597 → 782
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:408 → 519
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:72 → 261
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  2. XM_038174313.1 → XP_038030241.1  rho GTPase-activating protein 12 isoform X6

    UniProtKB/TrEMBL
    A0A493T1C5, A0A8B9ZE55
    Related
    ENSAPLP00030035370.1, ENSAPLT00030055078.1
    Conserved Domains (6) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    COG5104
    Location:265 → 360
    PRP40; Splicing factor [RNA processing and modification]
    cd00201
    Location:263 → 293
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:639 → 824
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:408 → 561
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:72 → 261
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  3. XM_038174311.1 → XP_038030239.1  rho GTPase-activating protein 12 isoform X4

    UniProtKB/TrEMBL
    A0A493SUI0, A0A8B9SVI0, R0KQF2
    Related
    ENSAPLP00030035596.1, ENSAPLT00030055399.1
    Conserved Domains (5) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:263 → 293
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:645 → 830
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:455 → 567
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:72 → 261
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  4. XM_038174309.1 → XP_038030237.1  rho GTPase-activating protein 12 isoform X2

    UniProtKB/TrEMBL
    R0KQF2
    Conserved Domains (5) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:263 → 293
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:685 → 870
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:455 → 607
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:72 → 261
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  5. XM_038174310.1 → XP_038030238.1  rho GTPase-activating protein 12 isoform X3

    UniProtKB/TrEMBL
    A0A493T8F9, R0KQF2
    Conserved Domains (5) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:263 → 293
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:682 → 838
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:455 → 608
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:72 → 261
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  6. XM_038174312.1 → XP_038030240.1  rho GTPase-activating protein 12 isoform X5

    UniProtKB/TrEMBL
    R0KQF2
    Conserved Domains (5) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:263 → 293
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:644 → 829
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:455 → 566
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:72 → 261
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  7. XM_038174306.1 → XP_038030234.1  rho GTPase-activating protein 12 isoform X1

    UniProtKB/TrEMBL
    R0KQF2, U3IJB0
    Related
    ENSAPLP00030035525.1, ENSAPLT00030055299.1
    Conserved Domains (5) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:263 → 293
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:686 → 871
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:455 → 608
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:72 → 261
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  8. XM_038174307.1 → XP_038030235.1  rho GTPase-activating protein 12 isoform X1

    UniProtKB/TrEMBL
    R0KQF2, U3IJB0
    Conserved Domains (5) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:263 → 293
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:686 → 871
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:455 → 608
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:72 → 261
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  9. XM_038174308.1 → XP_038030236.1  rho GTPase-activating protein 12 isoform X1

    UniProtKB/TrEMBL
    R0KQF2, U3IJB0
    Conserved Domains (5) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:263 → 293
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:686 → 871
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:455 → 608
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:72 → 261
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  10. XM_038174315.1 → XP_038030243.1  rho GTPase-activating protein 12 isoform X8

    Conserved Domains (4) summary
    cd00201
    Location:134 → 164
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:557 → 742
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:326 → 479
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:100 → 132
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  11. XM_038174316.1 → XP_038030244.1  rho GTPase-activating protein 12 isoform X9

    UniProtKB/TrEMBL
    R0KQF2
    Conserved Domains (5) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:263 → 293
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd13233
    Location:455 → 608
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:72 → 261
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
    cl02570
    Location:686 → 716
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

RNA

  1. XR_005263257.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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