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Ncoa1 nuclear receptor coactivator 1 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101726578, updated on 8-Mar-2024

Summary

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Gene symbol
Ncoa1
Gene description
nuclear receptor coactivator 1
Locus tag
GW7_13989
See related
Ensembl:ENSHGLG00000016470
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
22
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624738.1 (6770745..7054616)

NW_004624738.1Genomic Context describing neighboring genes Neighboring gene protein FAM228A-like Neighboring gene uncharacterized LOC110347905 Neighboring gene intersectin 2 Neighboring gene failed axon connections homolog pseudogene Neighboring gene fibronectin type III domain-containing protein 4-like Neighboring gene uncharacterized LOC110347906 Neighboring gene uncharacterized LOC110347907

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004624738 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Kim EB, et al. Nature, 2011 Oct 12. PMID 21993625, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nuclear receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nuclear receptor coactivator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624738.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    6770745..7054616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004839447.3 → XP_004839504.1  nuclear receptor coactivator 1

    UniProtKB/TrEMBL
    G5C390
    Related
    ENSHGLP00000023097.1, ENSHGLT00000023312.1
    Conserved Domains (9) summary
    smart00353
    Location:32 → 86
    HLH; helix loop helix domain
    cd00130
    Location:120 → 213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam09606
    Location:915 → 1311
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam00989
    Location:116 → 173
    PAS; PAS fold
    pfam07469
    Location:1164 → 1220
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:633 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:260 → 370
    PAS_11; PAS domain
    pfam16279
    Location:742 → 819
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:472 → 591
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
Nucleotide Protein
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