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Gne glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101705910, updated on 8-Mar-2024

Summary

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Gene symbol
Gne
Gene description
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
See related
Ensembl:ENSHGLG00000003036
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
19
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624868.1 (4362144..4417604)

NW_004624868.1Genomic Context describing neighboring genes Neighboring gene cell division control protein 42 homolog Neighboring gene transmembrane protein 126A pseudogene Neighboring gene clathrin light chain A Neighboring gene band 4.1-like protein 5 pseudogene

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004624868 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables N-acylmannosamine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables UDP-N-acetylglucosamine 2-epimerase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624868.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    4362144..4417604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004870102.3 → XP_004870159.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X1

    UniProtKB/TrEMBL
    A0A0P6J246, G5B0H7
    Related
    ENSHGLP00000004130.1, ENSHGLT00000004188.1
    Conserved Domains (4) summary
    cd03786
    Location:42 → 406
    GT1_UDP-GlcNAc_2-Epimerase; Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues ...
    COG1940
    Location:440 → 753
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    TIGR03568
    Location:42 → 405
    NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
    cl17037
    Location:441 → 700
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_004870108.3 → XP_004870165.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X3

    See identical proteins and their annotated locations for XP_004870165.1

    UniProtKB/TrEMBL
    G5B0H7
    Conserved Domains (2) summary
    COG1940
    Location:409 → 722
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    cl27436
    Location:11 → 374
    Epimerase_2; UDP-N-acetylglucosamine 2-epimerase

  3. XM_021248508.1 → XP_021104167.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X6

    UniProtKB/TrEMBL
    G5B0H7
    Conserved Domains (2) summary
    COG1940
    Location:350 → 654
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    cl27436
    Location:2 → 315
    Epimerase_2; UDP-N-acetylglucosamine 2-epimerase

  4. XM_004870105.3 → XP_004870162.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X3

    See identical proteins and their annotated locations for XP_004870162.1

    UniProtKB/TrEMBL
    G5B0H7
    Related
    ENSHGLP00000004131.1, ENSHGLT00000004189.1
    Conserved Domains (2) summary
    COG1940
    Location:409 → 722
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    cl27436
    Location:11 → 374
    Epimerase_2; UDP-N-acetylglucosamine 2-epimerase

  5. XM_021248506.1 → XP_021104165.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X4

    UniProtKB/TrEMBL
    G5B0H7
    Conserved Domains (2) summary
    COG1940
    Location:362 → 675
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    cl27436
    Location:9 → 327
    Epimerase_2; UDP-N-acetylglucosamine 2-epimerase

  6. XM_021248505.1 → XP_021104164.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X3

    UniProtKB/TrEMBL
    G5B0H7
    Related
    ENSHGLP00000004132.1, ENSHGLT00000004190.1
    Conserved Domains (2) summary
    COG1940
    Location:409 → 722
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    cl27436
    Location:11 → 374
    Epimerase_2; UDP-N-acetylglucosamine 2-epimerase

  7. XM_004870104.3 → XP_004870161.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X2

    UniProtKB/TrEMBL
    G5B0H7
    Conserved Domains (4) summary
    cd03786
    Location:35 → 399
    GT1_UDP-GlcNAc_2-Epimerase; Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues ...
    COG1940
    Location:433 → 746
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    TIGR03568
    Location:35 → 398
    NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
    cl17037
    Location:434 → 693
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  8. XM_004870107.3 → XP_004870164.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X6

    See identical proteins and their annotated locations for XP_004870164.1

    UniProtKB/TrEMBL
    G5B0H7
    Conserved Domains (2) summary
    COG1940
    Location:350 → 654
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    cl27436
    Location:2 → 315
    Epimerase_2; UDP-N-acetylglucosamine 2-epimerase

  9. XM_004870106.1 → XP_004870163.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X6

    See identical proteins and their annotated locations for XP_004870163.1

    UniProtKB/TrEMBL
    G5B0H7
    Conserved Domains (2) summary
    COG1940
    Location:350 → 654
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    cl27436
    Location:2 → 315
    Epimerase_2; UDP-N-acetylglucosamine 2-epimerase

  10. XM_021248507.1 → XP_021104166.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X5

    UniProtKB/TrEMBL
    G5B0H7
    Conserved Domains (2) summary
    COG1940
    Location:359 → 672
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    cl27436
    Location:6 → 324
    Epimerase_2; UDP-N-acetylglucosamine 2-epimerase
Nucleotide Protein
Heading Accession and Version

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