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DHRS9 dehydrogenase/reductase 9 [ Homo sapiens (human) ]

Gene ID: 10170, updated on 29-May-2016
Official Symbol
DHRS9provided by HGNC
Official Full Name
dehydrogenase/reductase 9provided by HGNC
Primary source
HGNC:HGNC:16888
See related
Ensembl:ENSG00000073737 HPRD:09916; MIM:612131; Vega:OTTHUMG00000132180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RDHL; RDH15; RDH-E2; RDHTBE; SDR9C4; RDH-TBE; RETSDR8; 3ALPHA-HSD; 3-alpha-HSD
Summary
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Orthologs
Location:
2q31.1
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (169067035..169096167)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (169921299..169952677)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene glucose-6-phosphatase catalytic subunit 2 Neighboring gene ATP binding cassette subfamily B member 11 Neighboring gene ubiquitin conjugating enzyme E2 V1 pseudogene 6 Neighboring gene LDL receptor related protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of dehydrogenase/reductase (SDR family) member 9 (DHRS9) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alcohol dehydrogenase (NAD) activity IDA
Inferred from Direct Assay
more info
PubMed 
racemase and epimerase activity NAS
Non-traceable Author Statement
more info
PubMed 
retinol dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
retinol dehydrogenase activity TAS
Traceable Author Statement
more info
 
testosterone dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
9-cis-retinoic acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
androgen metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
epithelial cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
progesterone metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
retinol metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
dehydrogenase/reductase SDR family member 9
Names
3-alpha hydroxysteroid dehydrogenase
NADP-dependent retinol dehydrogenase/reductase
dehydrogenase/reductase (SDR family) member 9
retinol dehydrogenase 15
retinol dehydrogenase homolog
short chain dehydrogenase/reductase family 9C member 4
short chain dehydrogenase/reductase family 9C, member 4
short-chain dehydrogenase/reductase retSDR8
tracheobronchial epithelial cell-specific retinol dehydrogenase

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142270.1NP_001135742.1  dehydrogenase/reductase SDR family member 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001135742.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 2. Variants 2-4 encode the same isoform (1).
    Source sequence(s)
    AF529287, CA307349, DB010228
    Consensus CDS
    CCDS2231.1
    UniProtKB/Swiss-Prot
    Q9BPW9
    Related
    ENSP00000407167, OTTHUMP00000204925, ENST00000436483, OTTHUMT00000333614
    Conserved Domains (2) summary
    PRK06914
    Location:30308
    PRK06914; short chain dehydrogenase; Provisional
    cd09805
    Location:30306
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
  2. NM_001142271.1NP_001135743.1  dehydrogenase/reductase SDR family member 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001135743.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. Variants 2-4 encode the same isoform (1).
    Source sequence(s)
    AY359046, CA307349
    Consensus CDS
    CCDS2231.1
    UniProtKB/Swiss-Prot
    Q9BPW9
    Related
    ENSP00000407747, ENST00000412271
    Conserved Domains (2) summary
    PRK06914
    Location:30308
    PRK06914; short chain dehydrogenase; Provisional
    cd09805
    Location:30306
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
  3. NM_001289763.1NP_001276692.1  dehydrogenase/reductase SDR family member 9 isoform 2

    See identical proteins and their annotated locations for NP_001276692.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and uses an upstream start codon, compared to variant 2. The encoded isoform (2) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AK296625, AY017349, BC040380
    Consensus CDS
    CCDS74600.1
    UniProtKB/Swiss-Prot
    Q9BPW9
    Related
    ENSP00000389241, ENST00000432060
    Conserved Domains (2) summary
    PRK06914
    Location:90368
    PRK06914; short chain dehydrogenase; Provisional
    cd09805
    Location:90366
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
  4. NM_199204.1NP_954674.1  dehydrogenase/reductase SDR family member 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_954674.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the shorter isoform (1). Variants 2-4 encode the same isoform.
    Source sequence(s)
    AY017349, BC051797
    Consensus CDS
    CCDS2231.1
    UniProtKB/Swiss-Prot
    Q9BPW9
    Related
    ENSP00000350154, OTTHUMP00000163043, ENST00000357546, OTTHUMT00000255232
    Conserved Domains (2) summary
    PRK06914
    Location:30308
    PRK06914; short chain dehydrogenase; Provisional
    cd09805
    Location:30306
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    169067035..169096167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510476.1XP_011508778.1  

    Conserved Domains (2) summary
    pfam00106
    Location:30193
    adh_short; short chain dehydrogenase
    cl21454
    Location:30191
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_011510475.1XP_011508777.1  

    See identical proteins and their annotated locations for XP_011508777.1

    UniProtKB/Swiss-Prot
    Q9BPW9
    Conserved Domains (2) summary
    PRK06914
    Location:30308
    PRK06914; short chain dehydrogenase; Provisional
    cd09805
    Location:30306
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    169929555..169958689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005771.4: Suppressed sequence

    Description
    NM_005771.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.