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    CDK2 cyclin-dependent kinase 2 [ Homo sapiens ]

    Gene ID: 1017, updated on 19-May-2012
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    Summary

    Official Symbol
    CDK2provided by HGNC
    Official Full Name
    cyclin-dependent kinase 2provided by HGNC
    Primary source
    HGNC:1771
    See related
    Ensembl:ENSG00000123374; HPRD:00310; MIM:116953; Vega:OTTHUMG00000170575
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p33(CDK2)
    Summary
    The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    12q13
    Sequence :
    Chromosome: 12; NC_000012.11 (56360556..56366568)
    See CDK2 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, alpha 80kDa Neighboring gene premelanosome protein Neighboring gene RAB13, member RAS oncogene family pseudogene Neighboring gene RAB5B, member RAS oncogene family Neighboring gene sulfite oxidase

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2. Buis J, et al. Nat Struct Mol Biol, 2012 Jan 8. PMID 22231403.
    2. Phosphorylation of MCM3 protein by cyclin E/cyclin-dependent kinase 2 (Cdk2) regulates its function in cell cycle. Li J, et al. J Biol Chem, 2011 Nov 18. PMID 21965652.
    3. NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. Mori T, et al. Cell Cycle, 2011 Oct 1. PMID 21952639.
    4. Epstein-Barr virus Rta-mediated transactivation of p21 and 14-3-3σ arrests cells at the G1/S transition by reducing cyclin E/CDK2 activity. Huang SY, et al. J Gen Virol, 2012 Jan. PMID 21918011.
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.

    See all (406) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The authors show that, in human and mouse, Mre11 controls these events through a direct interaction with CDK2 that is required for CtIP phosphorylation and BRCA1 interaction in normally dividing cells.
      Title: Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.
    2. Epstein-Barr virus Rta-mediated transactivation of p21 and 14-3-3sigma arrests cells at the G1/S transition by reducing cyclin E/CDK2 activity.
      Title: Epstein-Barr virus Rta-mediated transactivation of p21 and 14-3-3σ arrests cells at the G1/S transition by reducing cyclin E/CDK2 activity.
    3. RT-PCR and Western blotting results revealed that both mRNA and protein levels of CDK2 were significantly higher in tumor tissues.
      Title: NF-κB induces abnormal centrosome amplification by upregulation of CDK2 in laryngeal squamous cell cancer.
    4. excess of MCM3 up-regulates the phosphorylation of CHK1 Ser-345 and CDK2 Thr-14.
      Title: Phosphorylation of MCM3 protein by cyclin E/cyclin-dependent kinase 2 (Cdk2) regulates its function in cell cycle.
    5. NF-Y binds to CCAAT sequences in the Cyclin A promoter, as well as to those in the promoters of cell cycle G2 regulators such as CDC2, Cyclin B and CDC25C.
      Title: NF-Y binds to both G1- and G2-specific cyclin promoters; a possible role in linking CDK2/Cyclin A to CDK1/Cyclin B.
    6. CDK2 downregulation causes high apoptosis at the early time points
      Title: An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.
    7. Transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis.
      Title: Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis.
    8. anti-oncogenic role of miR-372 may be through control of cell growth and cell cycle progression by down-regulating the cell cycle genes CDK2 and cyclin A1
      Title: MicroRNA-372 is down-regulated and targets cyclin-dependent kinase 2 (CDK2) and cyclin A1 in human cervical cancer, which may contribute to tumorigenesis.
    9. cyclin E and CDK2 genes are key physiological effectors of the c-ETS1 proto-oncogene. Furthermore, c-ETS1 is indispensable for the hepatotropic action of HBx in cell cycle deregulation.
      Title: c-ETS1 facilitates G1/S-phase transition by up-regulating cyclin E and CDK2 genes and cooperates with hepatitis B virus X protein for their deregulation.
    10. Cdk2 is required for cell proliferation.
      Title: Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation.
    Submit: New GeneRIF Correction See all (161)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat Amino acid residues serine 16 and 46 of HIV-1 Tat are phosphorylated by CDK2; mutation of these two residues reduces HIV-1 transcription in cells PubMed
    tat Cdk2 phosphorylates HIV-1 Tat PubMed
    tat HIV-1 Tat induces Cdk2 to phosphorylate the RNA Polymerase C-terminal domain PubMed
    tat HIV-1 Tat induces Cyclin E-associated cdk activity in lymphocytes, indicating Tat drives cells to the late G1 phase of the cell cycle PubMed
    tat HIV-1 Tat 41/44 peptide TAALS from the core domain of Tat inhibits Tat-mediated HIV-1 gene expression and replication by binding the Cdk2/Cyclin E complex and inhibiting the phosphorylation of serine 5 of RNAPII PubMed
    tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed
    tat HIV-1 Tat induces a G1 arrest in cells of glial origin, leading to a downregulation of cyclin E-Cdk2 kinase activity and phosphorylation of Rb PubMed
    tat Cdk2/cyclin E stimulates Tat-dependent HIV-1 transcription PubMed
    tat Tat-mediated phosphorylation of RNA Polymerase C-terminal domain involves dynamic interactions of Cdk2 with Tat amino acids 15-24 and 36-49 and requires cysteine 22 in the activation domain of Tat and amino acids 42-72 of Tat PubMed
    tat Cdk2 activity is enhanced by HIV-1 Tat expression in Jurkat T cells and is associated with Tat-induced apoptosis PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001789.2 NP_009227.1 BRCA1    BIND  PubMed BRCA1 associates with CDK2 
    NP_001789.2 NP_001228.1 CCNA2    BIND  PubMed Interaction between Cyclin A2 (PDB ID: 1JST_D) and CDK2 (PDB ID: 1JST_C). 
    NP_001789.2 NP_001228.1 CCNA2    BIND  PubMed Interaction between CDK2 (PDB ID: 1JST_C) and Cyclin A2 (PDB ID: 1JST_B). 
    NP_001789.2 NP_001228.1 CCNA2    BIND  PubMed Interaction between Cyclin A2 (PDB ID: 1JST_D) and CDK2 (PDB ID: 1JST_A). 
    NP_001789.2 NP_000312.1 RB1    BIND  PubMed CDK2 phosphorylates Rb carboxy-terminus. 
    NP_001789.2 NP_005892.1 SMAD2    BIND  PubMed CDK2 phosphorylates Smad2. This interaction was modelled on a demonstrated interaction between Smad2 from an unspecified species and human CDK2. 
    NP_001789.2 NP_005893.1 SMAD3    BIND  PubMed CDK2 phosphorylates Smad3 on Thr8, Thr179, Ser204, Ser208 and Ser213. This interaction was modelled on a demonstrated interaction between Smad3 from an unspecified species and human CDK2. 
    NT_029419.10 MITF    BIND  PubMed MITF interacts with the CDK2 promoter. 
    P24941 P10415 BCL2    HPRD  PubMed  
    P24941 P38398 BRCA1    HPRD  PubMed  
    P24941 P51587 BRCA2    HPRD  PubMed  
    P24941 P78396 CCNA1    HPRD  PubMed  
    P24941 P20248 CCNA2    HPRD  PubMed  
    P24941 O95067 CCNB2    HPRD  PubMed  
    P24941 Q8WWL7 CCNB3    HPRD  PubMed  
    P24941 P24864 CCNE1    HPRD  PubMed  
    P24941 O96020 CCNE2    HPRD  PubMed  
    P24941 P51946 CCNH    HPRD  PubMed  
    P24941 O75909 CCNK    HPRD  PubMed  
    P24941 O43303 CCP110    HPRD  PubMed  
    P24941 P30304 CDC25A    HPRD  PubMed  
    P24941 Q16543 CDC37    HPRD  PubMed  
    P24941 Q99741 CDC6    HPRD  PubMed  
    P24941 O00311 CDC7    HPRD  PubMed  
    P24941 P24941 CDK2    HPRD  PubMed  
    P24941 Q8IZL9 CDK20    HPRD  PubMed  
    P24941 O14519 CDK2AP1    HPRD  PubMed  
    P24941 P50613 CDK7    HPRD  PubMed  
    P24941 P38936 CDKN1A    HPRD  PubMed  
    P24941 P46527 CDKN1B    HPRD  PubMed  
    P24941 Q16667 CDKN3    HPRD  PubMed  
    P24941 Q9H211 CDT1    HPRD  PubMed  
    P24941 Q99626 CDX2    HPRD  PubMed  
    P24941 P49715 CEBPA    HPRD  PubMed  
    P24941 Q13111 CHAF1A    HPRD  PubMed  
    P24941 Q13112 CHAF1B    HPRD  PubMed  
    P24941 P61024 CKS1B    HPRD  PubMed  
    P24941 Q9UIV1 CNOT7    HPRD  PubMed  
    P24941 P38432 COIL    HPRD  PubMed  
    P24941 Q09472 EP300    HPRD  PubMed  
    P24941 P39748 FEN1    HPRD  PubMed  
    P24941 Q08050 FOXM1    HPRD  PubMed  
    P24941 Q9UM11 FZR1    HPRD  PubMed  
    P24941 P54198 HIRA    HPRD  PubMed  
    P24941 P16401 HIST1H1B    HPRD  PubMed  
    P24941 Q02363 ID2    HPRD  PubMed  
    P24941 Q02535 ID3    HPRD  PubMed  
    P24941 P07948 LYN    HPRD  PubMed  
    P24941 P25205 MCM3    HPRD  PubMed  
    P24941 P33991 MCM4    HPRD  PubMed  
    P24941 P41218 MNDA    HPRD  PubMed  
    P24941 P10244 MYBL2    HPRD  PubMed  
    P24941 P15172 MYOD1    HPRD  PubMed  
    P24941 P23511 NFYA    HPRD  PubMed  
    P24941 Q9NQX5 NPDC1    HPRD  PubMed  
    P24941 P06748 NPM1    HPRD  PubMed  
    P24941 Q13415 ORC1    HPRD  PubMed  
    P24941 Q13416 ORC2    HPRD  PubMed  
    P24941 P12004 PCNA    HPRD  PubMed  
    P24941 P09884 POLA1    HPRD  PubMed  
    P24941 P28340 POLD1    HPRD  PubMed  
    P24941 P49005 POLD2    HPRD  PubMed  
    P24941 Q9UGP5 POLL    HPRD  PubMed  
    P24941 O75688 PPM1B    HPRD  PubMed  
    P24941 O43663 PRC1    HPRD  PubMed  
    P24941 P10644 PRKAR1A    HPRD  PubMed  
    P24941 P24723 PRKCH    HPRD  PubMed  
    P24941 P12272 PTHLH    HPRD  PubMed  
    P24941 P06454 PTMA    HPRD  PubMed  
    P24941 P17706 PTPN2    HPRD  PubMed  
    P24941 P06400 RB1    HPRD  PubMed  
    P24941 P28749 RBL1    HPRD  PubMed  
    P24941 Q08999 RBL2    HPRD  PubMed  
    P24941 Q13309 SKP2    HPRD  PubMed  
    P24941 P84022 SMAD3    HPRD  PubMed  
    P24941 Q5MJ70 SPDYA    HPRD  PubMed  
    P24941 P04637 TP53    HPRD  PubMed  
    P24941 O15350 TP73    HPRD  PubMed  
    P24941 Cell division autoantigen 1 TSPYL2    HPRD  PubMed  
    P24941 P49459 UBE2A    HPRD  PubMed  
    P24941 P17480 UBTF    HPRD  PubMed  
    P24941 Q96PU4 UHRF2    HPRD  PubMed  
    P24941 P30291 WEE1    HPRD  PubMed  
    BioGRID:107452 BioGRID:111861 ARID4A    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:121161 BCCIP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:106829 BIRC5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107452 BioGRID:107287 CASP4    BioGRID  PubMed Affinity Capture-MS 
    NP_003905.1 CCNA1    BIND  PubMed CCNA1 (CYCA) interacts with unspecified isoform of CDK2. 
    BioGRID:107452 BioGRID:114417 CCNA1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    NP_001228.1 CCNA2    BIND  PubMed Cdk2 interacts with Cyc A. 
    NP_001228.1 CCNA2    BIND  PubMed CDK2 interacts with CCNA2 (cyclin A) to form a complex. 
    NP_001228.1 CCNA2    BIND  PubMed Cyclin A interacts with cdk2. 
    NP_001228.1 CCNA2    BIND  PubMed CCNA2 (cyclin A) interacts with Cdk2. 
    BioGRID:107452 BioGRID:107331 CCNA2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107452 BioGRID:107332 CCNB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107452 BioGRID:124523 CCNB3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107452 BioGRID:107338 CCNE1    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:107452 BioGRID:114582 CCNE2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:107428 CDC25A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107452 BioGRID:107429 CDC25B    BioGRID  PubMed Two-hybrid 
    BioGRID:107452 BioGRID:107424 CDC5L    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:107426 CDC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:122381 CDK15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107452 BioGRID:113770 CDK2AP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107452 BioGRID:107456 CDK6    BioGRID  PubMed Co-purification 
    NP_001790.1 CDK7    BIND  PubMed CDK7 phosphorylates an unspecified isoform of CDK2. 
    BioGRID:107452 BioGRID:107457 CDK7    BioGRID  PubMed Biochemical Activity 
    NP_000380.1 CDKN1A    BIND  PubMed p21 interacts with an unspecified isoform of Cdk2. 
    NP_000380.1 CDKN1A    BIND  PubMed p21WAF1 interacts with an unspecified isoform of Cdk2. This interaction was modelled on a demonstrated interaction between human p21WAF1 and Cdk2 from an unspecified species. 
    NP_000380.1 CDKN1A    BIND  PubMed p21 interacts with Cdk2. 
    NP_000380.1 CDKN1A    BIND  PubMed p21 interacts with CDK2. This interaction was modeled on a demonstrated interaction between human p21 and hamster CDK2. 
    BioGRID:107452 BioGRID:107460 CDKN1A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    NP_004055.1 CDKN1B    BIND  PubMed Cdk2 interacts with p27. 
    NP_004055.1 CDKN1B    BIND  PubMed p27 interacts with an unspecified isoform of CDK2. 
    NP_004055.1 CDKN1B    BIND  PubMed Cdk2 interacts with p27kip1. 
    BioGRID:107452 BioGRID:107461 CDKN1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:107467 CDKN3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107452 BioGRID:123555 CDT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:107479 CEBPA    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:107452 BioGRID:107483 CEBPG    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:115349 CHAF1A    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107452 BioGRID:32835 CKS1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107452 BioGRID:107582 CKS1B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure 
    BioGRID:107452 BioGRID:107583 CKS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107452 BioGRID:118938 CNOT7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:112763 CNTN2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:198652 Cdkn1b    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107452 BioGRID:108201 E2F1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107452 BioGRID:108347 EP300    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107452 BioGRID:108349 EPB41    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107452 BioGRID:108446 EZH2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:122284 FAM113A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107452 BioGRID:108399 FBL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107452 BioGRID:108528 FEN1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107452 BioGRID:108594 FOXM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:109275 HIST1H1A    BioGRID  PubMed Biochemical Activity 
    NP_005313.1 HIST1H1B    BIND  PubMed An unspecified isoform of CDK2 phosphorylates H1. 
    BioGRID:107452 BioGRID:114089 IKBKG    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107452 BioGRID:33650 IME2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:107452 BioGRID:132642 INCA1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:108918 KAT2A    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107452 BioGRID:110245 LYN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:110340 MCM3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107452 BioGRID:110341 MCM4    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:110411 MGMT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:107370 MS4A3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:110690 MYBL2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:201633 Mybl2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:123072 NAA25    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107452 BioGRID:110815 NEDD8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107452 BioGRID:110918 NOV    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:121167 NPDC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107452 BioGRID:110929 NPM1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:114049 OGT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107452 BioGRID:111040 ORC1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107452 BioGRID:111041 ORC2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:111317 PIN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107452 BioGRID:111418 POLA1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:111490 PPM1B    BioGRID  PubMed Biochemical Activity; Co-purification 
    BioGRID:107452 BioGRID:111507 PPP2CA    BioGRID  PubMed Biochemical Activity; Co-purification 
    BioGRID:107452 BioGRID:111569 PRKCH    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:116327 PTP4A3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107452 BioGRID:36030 RAD53    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:107452 BioGRID:120823 RADIL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107452 BioGRID:111860 RB1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:111868 RBL1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:111869 RBL2    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107452 BioGRID:111871 RBM4    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:111898 REL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:120102 RRN3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107452 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107452 BioGRID:112180 SORT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107452 BioGRID:112550 SP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:128828 SPDYA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107452 BioGRID:113010 TP53    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:114374 TSC22D1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107452 BioGRID:122034 TSPYL2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107452 BioGRID:113167 UBE2A    BioGRID  PubMed Biochemical Activity 
    BioGRID:107452 BioGRID:114504 UBE2M    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107452 BioGRID:125434 UHRF2    BioGRID  PubMed Far Western 
    BioGRID:107452 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107452 BioGRID:119068 WRAP73    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107452 BioGRID:108822 XRCC6    BioGRID  PubMed Biochemical Activity 
    NP_057864.1 tax    BIND  PubMed Tax interacts with an unspecified isoform of Cdk2. 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the CDK2 gene: The CDK2 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, rice, and P.falciparum.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
      APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
    • Activation of ATR in response to replication stress, organism-specific biosystem (from REACTOME)
      Activation of ATR in response to replication stress, organism-specific biosystemGenotoxic stress caused by DNA damage or stalled replication forks can lead to genomic instability. To guard against such instability, genotoxically-stressed cells activate checkpoint factors that ha...
    • Activation of the pre-replicative complex, organism-specific biosystem (from REACTOME)
      Activation of the pre-replicative complex, organism-specific biosystemIn S. cerevisiae, two ORC subunits, Orc1 and Orc5, both bind ATP, and Orc1 in addition has ATPase activity. Both ATP binding and ATP hydrolysis appear to be essential functions in vivo. ATP binding b...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • BARD1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      BARD1 signaling events, organism-specific biosystem
      BARD1 signaling events
    • CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystem (from REACTOME)
      CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystemAs cells enter S phase, HsCdc6p is phosphorylated by CDK promoting its export from the nucleus (see Bell and Dutta 2002).
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
      Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemCyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. During G1 phase of the cell cycle, cyclin A is synthesized and associates with Cdk2. Af...
    • Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
      Cyclin E associated events during G1/S transition, organism-specific biosystemThe transition from the G1 to S phase is controlled by the Cyclin E:Cdk2 complexes. As the Cyclin E:Cdk2 complexes are formed, the Cdk2 is phosphorylated by the Wee1 and Myt1 kinases. This phosphoryl...
    • DNA Replication, organism-specific biosystem (from WikiPathways)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • DNA Replication Pre-Initiation, organism-specific biosystem (from REACTOME)
      DNA Replication Pre-Initiation, organism-specific biosystemAlthough, DNA replication occurs in the S phase of the cell cycle, the formation of the DNA replication pre-initiation complex begins during G1 phase.
    • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • FOXM1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      FOXM1 transcription factor network, organism-specific biosystem
      FOXM1 transcription factor network
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
      FoxO family signaling, organism-specific biosystem
      FoxO family signaling
    • G0 and Early G1, organism-specific biosystem (from REACTOME)
      G0 and Early G1, organism-specific biosystemIn G0 and early G1 in quiescent cells, p130 (RBL2) bound to E2F4 or E2F5 and either DP1 or DP2, associates with the MuvB complex, forming an evolutionarily conserved DREAM complex, that represses tra...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • G1/S DNA Damage Checkpoints, organism-specific biosystem (from REACTOME)
      G1/S DNA Damage Checkpoints, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding ...
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
    • G2 Phase, organism-specific biosystem (from REACTOME)
      G2 Phase, organism-specific biosystemThis is one of two 'gap' phases in the standard eukaryotic mitotic cell cycle. It is the interval between the completion of DNA synthesis and the beginning of mitosis. Protein synthesis occurs in th...
    • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
      G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common ga...
    • IL2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL2-mediated signaling events, organism-specific biosystem
      IL2-mediated signaling events
    • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
    • M/G1 Transition, organism-specific biosystem (from REACTOME)
      M/G1 Transition, organism-specific biosystemFinally, progression out of mitosis and division of the cell into two daughters (cytokinesis) requires the inactivation of Cyclin B - Cdc2 by ubiquitin-dependent proteolysis of Cyclin A and B, which ...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Meiosis, organism-specific biosystem (from REACTOME)
      Meiosis, organism-specific biosystemDuring meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing...
    • Meiotic Recombination, organism-specific biosystem (from REACTOME)
      Meiotic Recombination, organism-specific biosystemMeiotic recombination exchanges segments of duplex DNA between chromosomal homologs, generating genetic diversity (reviewed in Handel and Schimenti 2010, Inagaki et al. 2010, Cohen et al. 2006). Ther...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
      Mitotic G2-G2/M phases, organism-specific biosystem
      Mitotic G2-G2/M phases
    • Mitotic M-M/G1 phases, organism-specific biosystem (from REACTOME)
      Mitotic M-M/G1 phases, organism-specific biosystem
      Mitotic M-M/G1 phases
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
      Orc1 removal from chromatin, organism-specific biosystem
      Orc1 removal from chromatin
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes, organism-specific biosystem (from REACTOME)
      Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes, organism-specific biosystemThe G1/S transition is facilitated by Cyclin E:Cdk2-mediated phoshorylation of proteins including Rb and Cyclin Kinase Inhibitors (CKIs).
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
      Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemThe APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zacha...
    • Regulation of DNA replication, organism-specific biosystem (from REACTOME)
      Regulation of DNA replication, organism-specific biosystemDNA replication is regulated at various levels via ORC proteins. This pathway includes annotation of individual events that lead to the regulation of replication.
    • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
      Regulation of mitotic cell cycle, organism-specific biosystem
      Regulation of mitotic cell cycle
    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of nuclear SMAD2/3 signaling
    • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of retinoblastoma protein, organism-specific biosystem
      Regulation of retinoblastoma protein
    • Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
      Removal of licensing factors from origins, organism-specific biosystemLicensing factors are removed from the origin by various means like biochemical modification (phosphorylation) or by physical association with other proteins. This pathway includes the annotations of...
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continu...
    • SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystem (from REACTOME)
      SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystemDuring G1, the activity of cyclin-dependent kinases (CDKs) is kept in check by the CDK inhibitors (CKIs) p27 and p21, thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 20...
    • Signaling events mediated by PRL, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by PRL, organism-specific biosystem
      Signaling events mediated by PRL
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
      Switching of origins to a post-replicative state, organism-specific biosystem
      Switching of origins to a post-replicative state
    • Synthesis of DNA, organism-specific biosystem (from REACTOME)
      Synthesis of DNA, organism-specific biosystemThe actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of ...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
      p53 pathway, organism-specific biosystem
      p53 pathway
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53-Dependent G1 DNA Damage Response, organism-specific biosystem (from REACTOME)
      p53-Dependent G1 DNA Damage Response, organism-specific biosystemMost of the damage-induced modifications of p53 are dependent on the ATM kinase. The first link between ATM and p53 was predicted based on the earlier studies that showed that AT cells exhibit a redu...
    • p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystem (from REACTOME)
      p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystemThe arrest at G1/S checkpoint is mediated by the action of a widely known tumor suppressor protein, p53. Loss of p53 functions, as a result of mutations in cancer prevent the G1/S checkpoint (Kuerbi...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    cyclin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    cyclin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		  
    cyclin-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    		  
    contributes_to histone kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    kinase activity TAS
    Traceable Author Statement
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
    Traceable Author Statement
    more info
    		  
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA replication TAS
    Traceable Author Statement
    more info
    		  
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    G2 phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    M/G1 transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    Ras protein signal transduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell cycle IDA
    Inferred from Direct Assay
    more info
    		  
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to nitric oxide TAS
    Traceable Author Statement
    more info
    		  
    centrosome duplication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    histone phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    meiosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    mitotic cell cycle G1/S transition DNA damage checkpoint TAS
    Traceable Author Statement
    more info
    		  
    phosphorylation TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of DNA replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of gene silencing IDA
    Inferred from Direct Assay
    more info
    		  
    regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    traversing start control point of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Cajal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    X chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Y chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    centrosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    condensed chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endosome IDA
    Inferred from Direct Assay
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    cyclin-dependent kinase 2
    Names
    cyclin-dependent kinase 2
    p33 protein kinase
    cell devision kinase 2
    cdc2-related protein kinase
    cell division protein kinase 2
    NP_001789.2
    NP_439892.2
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001798.3 → NP_001789.2  cyclin-dependent kinase 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA810989, AK291941, BC003065, BJ991087
      Consensus CDS
      CCDS8898.1
      UniProtKB/Swiss-Prot
      P24941
      Related
      ENSP00000266970, OTTHUMP00000244047, ENST00000266970, OTTHUMT00000409650
      Conserved Domains (2) summary
      cd07860
      Location:3 – 286
      Blast Score: 1612
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3
      PLN00009
      Location:1 – 289
      Blast Score: 1230
      PLN00009; cyclin-dependent kinase A; Provisional

    2. NM_052827.2 → NP_439892.2  cyclin-dependent kinase 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal coding exon, as compared to variant 1. The translation remains in-frame, and the encoded isoform 2 lacks a 34 aa segment, as compared to isoform 1.
      Source sequence(s)
      AA810989, AB012305, BC003065, BJ991087
      Consensus CDS
      CCDS8899.1
      UniProtKB/Swiss-Prot
      P24941
      Related
      ENSP00000243067, OTTHUMP00000244052, ENST00000354056, OTTHUMT00000409656
      Conserved Domains (2) summary
      PLN00009
      Location:1 – 255
      Blast Score: 994
      PLN00009; cyclin-dependent kinase A; Provisional
      cl09925
      Location:3 – 252
      Blast Score: 1348
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      56360556..56366568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      53399466..53405479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC025162.48 (62873..67198) None
    genomic AC034102.32 (188515..190198) None
    genomic AF512553.1 AAM34794.1
    genomic CH471054.1 EAW96856.1
      EAW96857.1
      EAW96858.1
      EAW96859.1
      EAW96860.1
    genomic U50730.2 None
    mRNA AA810989.1 None
    mRNA AB012305.1 BAA32794.1
    mRNA AK291941.1 BAF84630.1
    mRNA AK293246.1 BAG56780.1
    mRNA BC003065.2 AAH03065.1
    mRNA BJ991087.1 None
    mRNA BT006821.1 AAP35467.1
    mRNA M68520.1 AAA35667.1
    mRNA X61622.1 CAA43807.1
    mRNA X62071.1 CAA43985.1
    other-genetic AM393136.1 CAL38014.1
    other-genetic DQ890598.2 ABM92215.1
    other-genetic DQ893767.2 ABM84693.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24941.2 GenPept UniProtKB/Swiss-Prot:P24941
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

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