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MDC1 mediator of DNA damage checkpoint 1 [ Mustela putorius furo (domestic ferret) ]

Gene ID: 101675735, updated on 8-Mar-2024

Summary

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Gene symbol
MDC1
Gene description
mediator of DNA damage checkpoint 1
See related
Ensembl:ENSMPUG00000011708
Gene type
protein coding
RefSeq status
MODEL
Organism
Mustela putorius furo (sub-species: furo)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae; Mustelinae; Mustela
Orthologs
human mouse all
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Genomic context

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See MDC1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
16
Annotation release Status Assembly Chr Location
102 current ASM1176430v1.1 (GCF_011764305.1) Unplaced Scaffold NW_025422008.1 (2152110..2167111)
101 previous assembly MusPutFur1.0 (GCF_000215625.1) Unplaced Scaffold NW_004569548.1 (258959..274152)

NW_025422008.1Genomic Context describing neighboring genes Neighboring gene flotillin 1 Neighboring gene tubulin beta class I Neighboring gene nurim Neighboring gene protein phosphatase 1 regulatory subunit 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De-novo transcriptome sequencing of a normalized cDNA pool from influenza infected ferrets. Camp JV, et al. PLoS One, 2012. PMID 22606336, Free PMC Article
  2. Sequencing, annotation, and characterization of the influenza ferret infectome. León AJ, et al. J Virol, 2013 Feb. PMID 23236062, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription initiation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mediator of DNA damage checkpoint protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mustela putorius furo Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1176430v1.1 Primary Assembly

Genomic

  1. NW_025422008.1 Reference ASM1176430v1.1 Primary Assembly

    Range
    2152110..2167111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004781593.3 → XP_004781650.2  mediator of DNA damage checkpoint protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8U0T7G8, M3YJV7
    Conserved Domains (4) summary
    PHA03247
    Location:1135 → 1684
    PHA03247; large tegument protein UL36; Provisional
    cd00060
    Location:56 → 131
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd17744
    Location:1796 → 1866
    BRCT_MDC1_rpt1; first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
    cd18441
    Location:1898 → 1978
    BRCT_MDC1_rpt2; second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins

  2. XM_045065205.1 → XP_044921140.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8U0RAU3, M3YJV7
    Conserved Domains (4) summary
    PHA03247
    Location:1104 → 1653
    PHA03247; large tegument protein UL36; Provisional
    cd00060
    Location:56 → 131
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd17744
    Location:1765 → 1835
    BRCT_MDC1_rpt1; first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
    cd18441
    Location:1867 → 1947
    BRCT_MDC1_rpt2; second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins

  3. XM_013050540.2 → XP_012905994.2  mediator of DNA damage checkpoint protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8U0T7G8, M3YJV7
    Conserved Domains (4) summary
    PHA03247
    Location:1135 → 1684
    PHA03247; large tegument protein UL36; Provisional
    cd00060
    Location:56 → 131
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd17744
    Location:1796 → 1866
    BRCT_MDC1_rpt1; first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
    cd18441
    Location:1898 → 1978
    BRCT_MDC1_rpt2; second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins

  4. XM_004781594.3 → XP_004781651.2  mediator of DNA damage checkpoint protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8U0NH58, M3YJV7
    Conserved Domains (4) summary
    PHA03247
    Location:1134 → 1683
    PHA03247; large tegument protein UL36; Provisional
    cd00060
    Location:56 → 131
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd17744
    Location:1795 → 1865
    BRCT_MDC1_rpt1; first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
    cd18441
    Location:1897 → 1977
    BRCT_MDC1_rpt2; second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins

  5. XM_004781595.3 → XP_004781652.2  mediator of DNA damage checkpoint protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8U0NG22, M3YJV7
    Conserved Domains (4) summary
    PHA03247
    Location:1046 → 1595
    PHA03247; large tegument protein UL36; Provisional
    cd00060
    Location:56 → 131
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd17744
    Location:1707 → 1777
    BRCT_MDC1_rpt1; first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
    cd18441
    Location:1809 → 1889
    BRCT_MDC1_rpt2; second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins

  6. XM_013050539.2 → XP_012905993.2  mediator of DNA damage checkpoint protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8U0T7G8, M3YJV7
    Conserved Domains (4) summary
    PHA03247
    Location:1135 → 1684
    PHA03247; large tegument protein UL36; Provisional
    cd00060
    Location:56 → 131
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd17744
    Location:1796 → 1866
    BRCT_MDC1_rpt1; first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
    cd18441
    Location:1898 → 1978
    BRCT_MDC1_rpt2; second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins

  7. XM_045065206.1 → XP_044921141.1  mediator of DNA damage checkpoint protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8U0R9E5, M3YJV7
    Conserved Domains (3) summary
    PHA03247
    Location:955 → 1504
    PHA03247; large tegument protein UL36; Provisional
    cd17744
    Location:1616 → 1686
    BRCT_MDC1_rpt1; first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
    cd18441
    Location:1718 → 1798
    BRCT_MDC1_rpt2; second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins

  8. XM_045065207.1 → XP_044921142.1  mediator of DNA damage checkpoint protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8U0R9E5, M3YJV7
    Conserved Domains (3) summary
    PHA03247
    Location:955 → 1504
    PHA03247; large tegument protein UL36; Provisional
    cd17744
    Location:1616 → 1686
    BRCT_MDC1_rpt1; first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
    cd18441
    Location:1718 → 1798
    BRCT_MDC1_rpt2; second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
Nucleotide Protein
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