Display Settings:

Format

Send to:

Choose Destination

LPAR6 lysophosphatidic acid receptor 6 [ Homo sapiens (human) ]

Gene ID: 10161, updated on 27-Sep-2014
Official Symbol
LPAR6provided by HGNC
Official Full Name
lysophosphatidic acid receptor 6provided by HGNC
Primary source
HGNC:HGNC:15520
See related
Ensembl:ENSG00000139679; HPRD:16465; MIM:609239; Vega:OTTHUMG00000016895
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAH3; P2Y5; ARWH1; HYPT8; P2RY5
Summary
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
See LPAR6 in Epigenomics, MapViewer
Location:
13q14
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 13 NC_000013.11 (48411045..48444704, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (48985181..49018840, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene retinoblastoma 1 Neighboring gene PEST containing nuclear protein pseudogene 5 Neighboring gene uncharacterized LOC101929434 Neighboring gene regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 Neighboring gene long intergenic non-protein coding RNA 462

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Nucleotide GPCRs, organism-specific biosystem (from WikiPathways)
    Nucleotide GPCRs, organism-specific biosystem
    Nucleotide GPCRs
  • Nucleotide-like (purinergic) receptors, organism-specific biosystem (from REACTOME)
    Nucleotide-like (purinergic) receptors, organism-specific biosystemPurinergic receptors (Burnstock G, 2006; Abbracchio MP et al, 2009) are a family of newly characterized plasma membrane molecules involved in several cellular functions such as vascular reactivity, a...
  • P2Y receptors, organism-specific biosystem (from REACTOME)
    P2Y receptors, organism-specific biosystemP2Y receptors are a family of purinergic receptors, G protein-coupled receptors stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in hum...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Markers

Homology

Clone Names

  • MGC120358

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
lysophosphatidic acid receptor 6
Names
lysophosphatidic acid receptor 6
LPA-6
LPA receptor 6
P2Y purinoceptor 5
purinergic receptor 5
G-protein coupled purinergic receptor P2Y5
RB intron encoded G-protein coupled receptor
oleoyl-L-alpha-lysophosphatidic acid receptor
purinergic receptor P2Y, G-protein coupled, 5
purinergic receptor P2Y G protein-coupled protein 5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012874.1 

    Range
    5001..38660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001162497.1NP_001155969.1  lysophosphatidic acid receptor 6

    See proteins identical to NP_001155969.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK122856, AK123059, BX647109
    Consensus CDS
    CCDS9410.1
    UniProtKB/TrEMBL
    A0A024RDT2
    UniProtKB/TrEMBL
    B3KVQ5
    UniProtKB/Swiss-Prot
    P43657
    Related
    ENSP00000344353, OTTHUMP00000018396, ENST00000345941, OTTHUMT00000044873
    Conserved Domains (2) summary
    pfam00001
    Location:40291
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10328
    Location:29142
    7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
  2. NM_001162498.1NP_001155970.1  lysophosphatidic acid receptor 6

    See proteins identical to NP_001155970.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK123059, BC040850, BF950635, BF951153, BX647109
    Consensus CDS
    CCDS9410.1
    UniProtKB/TrEMBL
    A0A024RDT2
    UniProtKB/TrEMBL
    B3KVQ5
    UniProtKB/Swiss-Prot
    P43657
    Conserved Domains (2) summary
    pfam00001
    Location:40291
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10328
    Location:29142
    7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
  3. NM_005767.5NP_005758.2  lysophosphatidic acid receptor 6

    See proteins identical to NP_005758.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK123059, BC045651, BX647109
    Consensus CDS
    CCDS9410.1
    UniProtKB/TrEMBL
    A0A024RDT2
    UniProtKB/TrEMBL
    B3KVQ5
    UniProtKB/Swiss-Prot
    P43657
    Related
    ENSP00000367691, OTTHUMP00000178634, ENST00000378434, OTTHUMT00000276280
    Conserved Domains (2) summary
    pfam00001
    Location:40291
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10328
    Location:29142
    7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000013.11 

    Range
    48411045..48444704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000145.1 

    Range
    29777751..29810928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 

    Range
    48952866..48985831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)