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Dhfr dihydrofolate reductase [ Jaculus jaculus (lesser Egyptian jerboa) ]

Gene ID: 101606923, updated on 8-Mar-2024

Summary

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Gene symbol
Dhfr
Gene description
dihydrofolate reductase
See related
EnsemblRapid:ENSJJAG00000027377
Gene type
protein coding
RefSeq status
MODEL
Organism
Jaculus jaculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Dipodoidea; Dipodidae; Dipodinae; Jaculus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
6
Annotation release Status Assembly Chr Location
102 current mJacJac1.mat.Y.cur (GCF_020740685.1) 14 NC_059115.1 (81974934..81998273)
101 previous assembly JacJac1.0 (GCF_000280705.1) Unplaced Scaffold NW_004504317.1 (50198940..50221958)

Chromosome 14 - NC_059115.1Genomic Context describing neighboring genes Neighboring gene Ras protein specific guanine nucleotide releasing factor 2 Neighboring gene mutS homolog 3 Neighboring gene U2 spliceosomal RNA Neighboring gene ankyrin repeat domain 34B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables dihydrofolate reductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in dihydrofolate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in folic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dihydrofolate reductase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Jaculus jaculus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mJacJac1.mat.Y.cur Primary Assembly

Genomic

  1. NC_059115.1 Reference mJacJac1.mat.Y.cur Primary Assembly

    Range
    81974934..81998273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004651649.2 → XP_004651706.1  dihydrofolate reductase isoform X1

    UniProtKB/TrEMBL
    A0A8C5K955, A0A8C5LNW8
    Related
    ENSJJAP00000031615.1, ENSJJAT00000034412.1
    Conserved Domains (1) summary
    cd00209
    Location:5 → 184
    DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...

  2. XM_045133878.1 → XP_044989813.1  dihydrofolate reductase isoform X2

Nucleotide Protein
Heading Accession and Version

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