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Tsc2 TSC complex subunit 2 [ Octodon degus (degu) ]

Gene ID: 101562804, updated on 8-Mar-2024

Summary

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Gene symbol
Tsc2
Gene description
TSC complex subunit 2
See related
Ensembl:ENSODEG00000013876
Gene type
protein coding
RefSeq status
MODEL
Organism
Octodon degus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Octodontidae; Octodon
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
42
Annotation release Status Assembly Chr Location
102 current OctDeg1.0 (GCF_000260255.1) Unplaced Scaffold NW_004524597.1 (9672136..9710657, complement)

NW_004524597.1Genomic Context describing neighboring genes Neighboring gene RAB26, member RAS oncogene family Neighboring gene polycystin 1, transient receptor potential channel interacting Neighboring gene nth like DNA glycosylase 1 Neighboring gene NHERF family PDZ scaffold protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004524597 Unplaced Scaffold Reference OctDeg1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of TSC1-TSC2 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tuberin
Names
tuberous sclerosis 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Octodon degus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference OctDeg1.0 Primary Assembly

Genomic

  1. NW_004524597.1 Reference OctDeg1.0 Primary Assembly

    Range
    9672136..9710657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004627871.3 → XP_004627928.1  tuberin isoform X6

    UniProtKB/TrEMBL
    A0A6P3EXZ6
    Conserved Domains (3) summary
    pfam02145
    Location:1541 → 1727
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:554 → 902
    Tuberin; Tuberin
    pfam11864
    Location:53 → 465
    DUF3384; Domain of unknown function (DUF3384)

  2. XM_012513954.2 → XP_012369408.1  tuberin isoform X3

    UniProtKB/TrEMBL
    A0A6P3VAC7
    Related
    ENSODEP00000018823.1, ENSODET00000019061.1
    Conserved Domains (3) summary
    pfam02145
    Location:1564 → 1750
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:554 → 902
    Tuberin; Tuberin
    pfam11864
    Location:53 → 465
    DUF3384; Domain of unknown function (DUF3384)

  3. XM_023711863.1 → XP_023567631.1  tuberin isoform X5

    UniProtKB/TrEMBL
    A0A6P6E5V6
    Conserved Domains (3) summary
    pfam02145
    Location:1542 → 1728
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:573 → 880
    Tuberin
    pfam11864
    Location:96 → 487
    DUF3384; Domain of unknown function (DUF3384)

  4. XM_023711866.1 → XP_023567634.1  tuberin isoform X8

    UniProtKB/TrEMBL
    A0A6P6E5J0
    Conserved Domains (3) summary
    pfam02145
    Location:1539 → 1725
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:573 → 921
    Tuberin
    pfam11864
    Location:96 → 487
    DUF3384; Domain of unknown function (DUF3384)

  5. XM_023711867.1 → XP_023567635.1  tuberin isoform X9

    UniProtKB/TrEMBL
    A0A6P6E5W2
    Conserved Domains (3) summary
    pfam02145
    Location:1517 → 1703
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:573 → 921
    Tuberin
    pfam11864
    Location:96 → 487
    DUF3384; Domain of unknown function (DUF3384)

  6. XM_023711864.1 → XP_023567632.1  tuberin isoform X7

    UniProtKB/TrEMBL
    A0A6P6E656
    Conserved Domains (3) summary
    pfam02145
    Location:1540 → 1726
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:573 → 921
    Tuberin
    pfam11864
    Location:96 → 487
    DUF3384; Domain of unknown function (DUF3384)

  7. XM_023711861.1 → XP_023567629.1  tuberin isoform X2

    UniProtKB/TrEMBL
    A0A6P6E5I6
    Conserved Domains (3) summary
    pfam02145
    Location:1582 → 1768
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:573 → 921
    Tuberin
    pfam11864
    Location:96 → 487
    DUF3384; Domain of unknown function (DUF3384)

  8. XM_023711862.1 → XP_023567630.1  tuberin isoform X4

    UniProtKB/TrEMBL
    A0A6P6E5V7
    Conserved Domains (3) summary
    pfam02145
    Location:1560 → 1746
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:573 → 921
    Tuberin
    pfam11864
    Location:96 → 487
    DUF3384; Domain of unknown function (DUF3384)

  9. XM_023711860.1 → XP_023567628.1  tuberin isoform X1

    UniProtKB/TrEMBL
    A0A6P6E6H3
    Conserved Domains (3) summary
    pfam02145
    Location:1583 → 1769
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:573 → 921
    Tuberin
    pfam11864
    Location:96 → 487
    DUF3384; Domain of unknown function (DUF3384)

  10. XM_012513955.2 → XP_012369409.1  tuberin isoform X11

    UniProtKB/TrEMBL
    A0A6P3V9P9
    Conserved Domains (3) summary
    pfam02145
    Location:1497 → 1683
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:554 → 902
    Tuberin; Tuberin
    pfam11864
    Location:53 → 465
    DUF3384; Domain of unknown function (DUF3384)

  11. XM_004627873.3 → XP_004627930.1  tuberin isoform X10

    UniProtKB/TrEMBL
    A0A6P3F0R4
    Related
    ENSODEP00000018824.1, ENSODET00000019062.1
    Conserved Domains (3) summary
    pfam02145
    Location:1498 → 1684
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:554 → 902
    Tuberin; Tuberin
    pfam11864
    Location:53 → 465
    DUF3384; Domain of unknown function (DUF3384)
Nucleotide Protein
Heading Accession and Version

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