EBI3 Epstein-Barr virus induced 3 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: EBI3provided by HGNC
Official Full Name: Epstein-Barr virus induced 3provided by HGNC
Primary source: HGNC:3129
See related: Ensembl:ENSG00000105246; HPRD:12051; MIM:605816; Vega:OTTHUMG00000181866
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IL27B; IL-27B
Summary: This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]

Genomic context

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Location :: 19p13.3

Sequence :: Chromosome: 19; NC_000019.9 (4229540..4237525)

See EBI3 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results reveal a novel functional role for IL-35 in suppressing cancer activity, inhibiting cancer cell growth, and increasing the apoptosis sensitivity of human cancer cells through the regulation of genes related to the cell cycle and apoptosis.
Title: IL-35 over-expression increases apoptosis sensitivity and suppresses cell growth in human cancer cells.
The findings of this study support the potential role of regulatory T cells and genetic variations in the regions around FOXP3 and EBI3 genes in modifying the risk for AR development in Chinese patients.
Title: Association between polymorphisms in FOXP3 and EBI3 genes and the risk for development of allergic rhinitis in Chinese subjects.
This study demonstrated that interleukin-35 expression could be detected in the CD4(+) T cells from peripheral blood of chronic hepatitis B patients.
Title: Detectable expression of IL-35 in CD4+ T cells from peripheral blood of chronic hepatitis B patients.
IL-27 expression is one host immune factor produced in response to influenza A virus infection and that elevated IL-27 levels inhibit viral replication.
Title: Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling.
Data show that Epstein-Barr virus-induced gene 3 (EBI3) is differentially expressed among Burkitt lymphoma and diffuse large B-cell lymphoma.
Title: Epstein-Barr virus-induced gene 3 (EBI3): a novel diagnosis marker in Burkitt lymphoma and diffuse large B-cell lymphoma.
Our data support a possible role of Ebi3 in atherogenesis
Title: Epstein-barr virus-induced gene-3 is expressed in human atheroma plaques.
findings indicate that the restricted Th1 responses in newborns owing to deficient IL-12 production may be compensated for, in part, by enhanced IL-27 secretion
Title: Enhanced expression of IL-27 mRNA in human newborns.
The genome-wide mRNA expression profile under the condition of short-term stimulation (4h) with IL-18 using the Affymetrix GeneChip((R)) Array System, was characterized.
Title: Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: critical role of two kappaB binding sites in the human EBI3 promotor.
results suggest that increased numbers of Epstein-Barr virus-infected cells in areas of active inflammatory bowel disease are secondary to influx or local proliferation of inflammatory cells & do not contribute significantly to local production of EBI3
Title: Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease.
a new heterodimeric cytokine that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL-12p35-related polypeptide (IL-27)
Title: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
Q14213	P27824	CANX	HPRD	PubMed
Q14213	O95249	GOSR1	HPRD	PubMed
Q14213	P29459	IL12A	HPRD	PubMed
Q14213	Q6UWB1	IL27RA	HPRD	PubMed
Q14213	Q99750	MDFI	HPRD	PubMed
Q14213	P84022	SMAD3	HPRD	PubMed
BioGRID:115450	BioGRID:107271	CANX	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115450	BioGRID:114903	GOSR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115450	BioGRID:114852	IL27RA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115450	BioGRID:110353	MDFI	BioGRID	PubMed	Two-hybrid
BioGRID:115450	BioGRID:110263	SMAD3	BioGRID	PubMed	Two-hybrid

Pathways from BioSystems

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IL27-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL27-mediated signaling events, organism-specific biosystem
IL27-mediated signaling events

General gene information

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Markers

G54090 (e-PCR)
- UniSTS:109327

STS-L08187 (e-PCR)
- UniSTS:34918

D19S988 (e-PCR)
- UniSTS:64905

Homology

Homologs of the EBI3 gene: The EBI3 gene is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
cytokine activity	IEA Inferred from Electronic Annotation more info
cytokine receptor activity	IPI Inferred from Physical Interaction more info	PubMed
interleukin-27 receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
T-helper 1 type immune response	TAS Traceable Author Statement more info	PubMed
cytokine-mediated signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
humoral immune response	TAS Traceable Author Statement more info	PubMed
positive regulation of alpha-beta T cell proliferation	TAS Traceable Author Statement more info	PubMed
positive regulation of interferon-gamma biosynthetic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
extracellular space	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: interleukin-27 subunit beta

Names: interleukin-27 subunit beta; IL27 subunit; IL35 subunit; cytokine receptor; IL-27 subunit beta; EBV-induced gene 3 protein; Epstein-Barr virus induced gene 3; epstein-Barr virus-induced gene 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005755.2 → NP_005746.2 interleukin-27 subunit beta precursor

Status: REVIEWED

Source sequence(s)

L08187

Consensus CDS

CCDS12123.1

UniProtKB/Swiss-Prot

Q14213

Related

ENSP00000221847, OTTHUMP00000267700, ENST00000221847, OTTHUMT00000458005

Conserved Domains (2) summary

cd00063
Location:129 – 222
Blast Score: 121

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

smart00060
Location:47 – 115
Blast Score: 84

FN3; Fibronectin type 3 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p10 Primary Assembly

Range

4229540..4237525

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

3992754..4000739

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018930.1 Alternate CHM1_1.0

Range

4153279..4161224

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01056081.1 (66296..74281)	None
genomic	AC005578.1	AAC33488.1
genomic	AMYH01009329.1 (30635..38580)	None
genomic	CH471139.2	EAW69244.1
		EAW69245.1
genomic	HH821931.1	CBX32665.1
genomic	HH821932.1	CBX32666.1
mRNA	BC015364.1	AAH15364.1
mRNA	BC046112.1	AAH46112.1
mRNA	L08187.1	AAA93193.1
other-genetic	DQ891589.2	ABM82515.1
other-genetic	EU176581.1	ABW03382.1