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INSR insulin receptor [ Odobenus rosmarus divergens (Pacific walrus) ]

Gene ID: 101363371, updated on 11-Apr-2024

Summary

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Gene symbol
INSR
Gene description
insulin receptor
Gene type
protein coding
RefSeq status
MODEL
Organism
Odobenus rosmarus divergens (sub-species: divergens)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae; Odobenus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
22
Annotation release Status Assembly Chr Location
101 current Oros_1.0 (GCF_000321225.1) Unplaced Scaffold NW_004450879.1 (1036770..1161838)

NW_004450879.1Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene zinc finger protein 558-like Neighboring gene ferritin heavy chain pseudogene

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004450879.1 Unplaced Scaffold Reference Oros_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of insulin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Odobenus rosmarus divergens Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Oros_1.0 Primary Assembly

Genomic

  1. NW_004450879.1 Reference Oros_1.0 Primary Assembly

    Range
    1036770..1161838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004412178.1 → XP_004412235.1  insulin receptor isoform X2

    UniProtKB/TrEMBL
    A0A2U3WSD9
    Conserved Domains (6) summary
    cd05061
    Location:1003 → 1290
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:854 → 931
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:234 → 281
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:179 → 337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359 → 472
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1010 → 1277
    Pkinase_Tyr; Protein tyrosine kinase

  2. XM_004412177.1 → XP_004412234.1  insulin receptor isoform X1

    UniProtKB/TrEMBL
    A0A2U3WSM4
    Conserved Domains (6) summary
    cd05061
    Location:1015 → 1302
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:866 → 943
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:234 → 281
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:179 → 337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359 → 472
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1022 → 1289
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein
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