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NAMPT nicotinamide phosphoribosyltransferase [ Homo sapiens (human) ]

Gene ID: 10135, updated on 22-Dec-2014
Official Symbol
NAMPTprovided by HGNC
Official Full Name
nicotinamide phosphoribosyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:30092
See related
Ensembl:ENSG00000105835; HPRD:09938; MIM:608764; Vega:OTTHUMG00000140388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik
Summary
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
See NAMPT in Epigenomics, MapViewer
Location:
7q22.3
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (106248285..106285732, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (105888731..105926373, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene synaptophysin-like 1 Neighboring gene DDB1 and CUL4 associated factor 13 pseudogene 1 Neighboring gene uncharacterized LOC102724339 Neighboring gene coiled-coil domain containing 71-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-induced LTR transactivation is reversed by tanshinone II A through the AMPK-Nampt pathway PubMed
tat HIV-1 Tat-induced inhibition of NAMPT protein expression and depletion of NAD(+) levels in TZM-bl cells are reversed by tanshinone II A (a main lipid-soluble monomer derivative from the root of Salvia miltiorrhiza) PubMed
tat HIV-1 Tat upregulates miR-182 in TZM-bl cells. MiR-182 significantly inhibits NAMPT protein expression by acting on the 3'-UTR of the NAMPT mRNA PubMed
tat Tat causes NAD(+) depletion and inhibits Nicotinamide phosphoribosyltransferase (Nampt) mRNA and protein expression in cells. Nampt is critical in the regulation of Tat-induced inhibition of sirtuin 1 (SIRT1) activity and LTR transactivation PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC117256, DKFZp666B131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
drug binding IEA
Inferred from Electronic Annotation
more info
 
nicotinamide phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
NAD metabolic process TAS
Traceable Author Statement
more info
 
NOT adipose tissue development IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
NOT insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
nicotinamide metabolic process TAS
Traceable Author Statement
more info
 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
vitamin metabolic process TAS
Traceable Author Statement
more info
 
water-soluble vitamin metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
nicotinamide phosphoribosyltransferase
Names
nicotinamide phosphoribosyltransferase
NAmPRTase
pre-B cell-enhancing factor
pre-B-cell colony enhancing factor 1
pre-B-cell colony-enhancing factor 1
NP_005737.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005746.2NP_005737.1  nicotinamide phosphoribosyltransferase precursor

    See proteins identical to NP_005737.1

    Status: REVIEWED

    Source sequence(s)
    AC007032, AI299587, BC106046, U02020
    Consensus CDS
    CCDS5737.1
    UniProtKB/TrEMBL
    A0A024R718
    UniProtKB/Swiss-Prot
    P43490
    Related
    ENSP00000222553, OTTHUMP00000179149, ENST00000222553, OTTHUMT00000277146
    Conserved Domains (2) summary
    PRK09198
    Location:10481
    PRK09198; putative nicotinate phosphoribosyltransferase; Provisional
    cd01569
    Location:12428
    PBEF_like; pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    106248285..106285732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250100.1XP_005250157.1  

    See proteins identical to XP_005250157.1

    UniProtKB/TrEMBL
    A0A024R718
    UniProtKB/Swiss-Prot
    P43490
    Conserved Domains (2) summary
    PRK09198
    Location:10481
    PRK09198; putative nicotinate phosphoribosyltransferase; Provisional
    cd01569
    Location:12428
    PBEF_like; pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, ...

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    105822212..105859137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    100248062..100285253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182790.1: Suppressed sequence

    Description
    NM_182790.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.