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NOX4 NADPH oxidase 4 [ Tursiops truncatus (common bottlenose dolphin) ]

Gene ID: 101336655, updated on 8-Mar-2024

Summary

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Gene symbol
NOX4
Gene description
NADPH oxidase 4
See related
EnsemblRapid:ENSTTRG00000012654
Gene type
protein coding
RefSeq status
MODEL
Organism
Tursiops truncatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Tursiops
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
18
Annotation release Status Assembly Chr Location
102 current mTurTru1.mat.Y (GCF_011762595.1) 8 NC_047041.1 (42972921..43123082)
101 previous assembly NIST Tur_tru v1 (GCF_001922835.1) Unplaced Scaffold NW_017844196.1 (5141801..5282962)

Chromosome 8 - NC_047041.1Genomic Context describing neighboring genes Neighboring gene lysine-specific demethylase 4D-like Neighboring gene tripartite motif-containing protein 77-like Neighboring gene uncharacterized LOC117313400 Neighboring gene U6 spliceosomal RNA Neighboring gene tyrosinase Neighboring gene glutamate metabotropic receptor 5 Neighboring gene uncharacterized LOC109552342

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables superoxide-generating NAD(P)H oxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of NADPH oxidase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NADPH oxidase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Tursiops truncatus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mTurTru1.mat.Y Primary Assembly

Genomic

  1. NC_047041.1 Reference mTurTru1.mat.Y Primary Assembly

    Range
    42972921..43123082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_033862150.1 → XP_033718041.1  NADPH oxidase 4 isoform X1

    UniProtKB/TrEMBL
    A0A6J3RTS4
    Related
    ENSTTRP00000012013.2, ENSTTRT00000012661.2
    Conserved Domains (2) summary
    cd06186
    Location:311 → 577
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam01794
    Location:69 → 204
    Ferric_reduct; Ferric reductase like transmembrane component

  2. XM_033862151.1 → XP_033718042.1  NADPH oxidase 4 isoform X2

    UniProtKB/TrEMBL
    A0A6J3RTZ9
    Related
    ENSTTRP00000019470.1, ENSTTRT00000033190.1
    Conserved Domains (2) summary
    cd06186
    Location:274 → 540
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam01794
    Location:54 → 167
    Ferric_reduct; Ferric reductase like transmembrane component

  3. XM_033862152.1 → XP_033718043.1  NADPH oxidase 4 isoform X3

    UniProtKB/TrEMBL
    A0A6J3RU99
    Conserved Domains (2) summary
    cd06186
    Location:237 → 503
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam01794
    Location:4 → 130
    Ferric_reduct; Ferric reductase like transmembrane component
Nucleotide Protein
Heading Accession and Version

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