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Dyrk4 dual-specificity tyrosine phosphorylation regulated kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 101320, updated on 21-Apr-2024

Summary

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Official Symbol
Dyrk4provided by MGI
Official Full Name
dual-specificity tyrosine phosphorylation regulated kinase 4provided by MGI
Primary source
MGI:MGI:1330292
See related
Ensembl:ENSMUSG00000030345 AllianceGenome:MGI:1330292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dyrk4a; Dyrk4b
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Orthologous to human DYRK4 (dual specificity tyrosine phosphorylation regulated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 6.9) See more
Orthologs
human all
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Genomic context

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Location:
6 F3; 6 61.92 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126852983..126899039, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126876020..126922083, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700018A23 gene Neighboring gene NADH:ubiquinone oxidoreductase subunit A9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:126799059-126799305 Neighboring gene A kinase anchor protein 3 Neighboring gene RAD51 associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E688 Neighboring gene STARR-positive B cell enhancer ABC_E6491 Neighboring gene metaxin 1 pseudogene Neighboring gene DNA segment, Chr 6, Wayne State University 163, expressed Neighboring gene STARR-positive B cell enhancer ABC_E8131

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity. Papadopoulos C, et al. J Biol Chem, 2011 Feb 18. PMID 21127067, Free PMC Article
  2. The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice. Sacher F, et al. Mol Cell Endocrinol, 2007 Mar 15. PMID 17292540
  3. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. Becker W, et al. J Biol Chem, 1998 Oct 2. PMID 9748265
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DYRK1A, DYRK2, and DYRK4 differ in their target recognition sequence and that preference for an arginine residue at position P -3 is a feature of DYRK1A but not of DYRK2 and DYRK4.
    Title: Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.
  2. Dyrk4 is a testis-specific kinase with a very restricted expression to stage VIII postmeiotic spermatids.
    Title: The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 4
Names
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
NP_997093.2
XP_006505316.1
XP_006505318.1
XP_006505319.1
XP_011239406.1
XP_011239407.1
XP_011239409.1
XP_036021600.1
XP_036021601.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207210.3 → NP_997093.2  dual specificity tyrosine-phosphorylation-regulated kinase 4

    See identical proteins and their annotated locations for NP_997093.2

    Status: VALIDATED

    Source sequence(s)
    AC165085
    Consensus CDS
    CCDS20559.2
    UniProtKB/Swiss-Prot
    Q80WP9, Q8BI55
    Related
    ENSMUSP00000077606.6, ENSMUST00000078521.7
    Conserved Domains (2) summary
    smart00220
    Location:219 → 515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14225
    Location:175 → 515
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    126852983..126899039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241105.3 → XP_011239407.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X2

    Conserved Domains (1) summary
    cd14225
    Location:218 → 558
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

  2. XM_011241104.3 → XP_011239406.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X1

    Conserved Domains (1) summary
    cd14225
    Location:228 → 568
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

  3. XM_006505255.3 → XP_006505318.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X4

    Conserved Domains (1) summary
    cd14225
    Location:185 → 525
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

  4. XM_006505253.1 → XP_006505316.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X3

    See identical proteins and their annotated locations for XP_006505316.1

    Conserved Domains (1) summary
    cd14225
    Location:209 → 549
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

  5. XM_006505256.5 → XP_006505319.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X5

    Related
    ENSMUST00000032495.10
    Conserved Domains (1) summary
    cd14225
    Location:149 → 489
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

  6. XM_036165708.1 → XP_036021601.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X8

    Conserved Domains (1) summary
    cl21453
    Location:1 → 232
    PKc_like; Protein Kinases, catalytic domain

  7. XM_011241107.3 → XP_011239409.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:228 → 486
    PKc_like; Protein Kinases, catalytic domain

  8. XM_036165707.1 → XP_036021600.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:228 → 488
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BI55.1 GenPept UniProtKB/Swiss-Prot:Q8BI55

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