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ITSN2 intersectin 2 [ Tursiops truncatus (common bottlenose dolphin) ]

Gene ID: 101318950, updated on 8-Mar-2024

Summary

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Gene symbol
ITSN2
Gene description
intersectin 2
See related
EnsemblRapid:ENSTTRG00000013435
Gene type
protein coding
RefSeq status
MODEL
Organism
Tursiops truncatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Tursiops
Orthologs
human mouse all
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Genomic context

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See ITSN2 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
47
Annotation release Status Assembly Chr Location
102 current mTurTru1.mat.Y (GCF_011762595.1) 14 NC_047047.1 (70135640..70296947)
101 previous assembly NIST Tur_tru v1 (GCF_001922835.1) Unplaced Scaffold NW_017843712.1 (42730155..42876592)

Chromosome 14 - NC_047047.1Genomic Context describing neighboring genes Neighboring gene centromere protein O Neighboring gene peptidyl-tRNA hydrolase domain containing 1 Neighboring gene nuclear receptor coactivator 1 Neighboring gene thioredoxin-like Neighboring gene importin subunit alpha-1-like Neighboring gene uncharacterized LOC117307953 Neighboring gene family with sequence similarity 228 member B Neighboring gene chromobox protein homolog 1-like Neighboring gene profilin family member 4 Neighboring gene tumor protein p53 inducible protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endosomal transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intracellular vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
intersectin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Tursiops truncatus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mTurTru1.mat.Y Primary Assembly

Genomic

  1. NC_047047.1 Reference mTurTru1.mat.Y Primary Assembly

    Range
    70135640..70296947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_019943133.2 → XP_019798692.1  intersectin-2 isoform X1

    UniProtKB/TrEMBL
    A0A2U4BZV3
    Conserved Domains (13) summary
    cd08375
    Location:1512 → 1646
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:720 → 776
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:859 → 910
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:942 → 993
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1014 → 1072
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1087 → 1140
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1171 → 1351
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam09756
    Location:365 → 425
    DDRGK; DDRGK domain
    pfam15279
    Location:90 → 170
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:776 → 859
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1369 → 1511
    PH_13; Pleckstrin homology domain
    cl25732
    Location:397 → 726
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_019943137.2 → XP_019798696.1  intersectin-2 isoform X2

    UniProtKB/TrEMBL
    A0A2U4BZY6
    Conserved Domains (13) summary
    cd08375
    Location:1498 → 1632
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:1 → 93
    EH; Eps15 homology domain
    cd11988
    Location:706 → 762
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:845 → 896
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:928 → 979
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1000 → 1058
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1073 → 1126
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1157 → 1337
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam09756
    Location:351 → 411
    DDRGK; DDRGK domain
    pfam15279
    Location:76 → 156
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:762 → 845
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1355 → 1497
    PH_13; Pleckstrin homology domain
    cl25732
    Location:383 → 712
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_019943132.2 → XP_019798691.1  intersectin-2 isoform X1

    UniProtKB/TrEMBL
    A0A2U4BZV3
    Conserved Domains (13) summary
    cd08375
    Location:1512 → 1646
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:720 → 776
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:859 → 910
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:942 → 993
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1014 → 1072
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1087 → 1140
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1171 → 1351
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam09756
    Location:365 → 425
    DDRGK; DDRGK domain
    pfam15279
    Location:90 → 170
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:776 → 859
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1369 → 1511
    PH_13; Pleckstrin homology domain
    cl25732
    Location:397 → 726
    SMC_N; RecF/RecN/SMC N terminal domain

  4. XM_019943139.2 → XP_019798698.1  intersectin-2 isoform X3

    UniProtKB/TrEMBL
    A0A2U4BZV6
    Conserved Domains (12) summary
    cd08375
    Location:1443 → 1577
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:651 → 707
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:790 → 841
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:873 → 924
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:945 → 1003
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1018 → 1071
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1102 → 1282
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam09756
    Location:296 → 356
    DDRGK; DDRGK domain
    pfam16617
    Location:707 → 790
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1300 → 1442
    PH_13; Pleckstrin homology domain
    cl25732
    Location:328 → 657
    SMC_N; RecF/RecN/SMC N terminal domain

  5. XM_019943144.2 → XP_019798703.1  intersectin-2 isoform X5

    UniProtKB/TrEMBL
    A0A2U4BZW2
    Conserved Domains (12) summary
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:720 → 776
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:859 → 910
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:942 → 993
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1014 → 1072
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1087 → 1140
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1171 → 1351
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam09756
    Location:365 → 425
    DDRGK; DDRGK domain
    pfam15279
    Location:90 → 170
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:776 → 859
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17171
    Location:1369 → 1447
    PH-like; Pleckstrin homology-like domain
    cl25732
    Location:397 → 726
    SMC_N; RecF/RecN/SMC N terminal domain

  6. XM_033838942.1 → XP_033694833.1  intersectin-2 isoform X6

    UniProtKB/TrEMBL
    A0A6J3PY75
    Related
    ENSTTRP00000028349.1, ENSTTRT00000026967.1
    Conserved Domains (9) summary
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:720 → 776
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:859 → 910
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:942 → 993
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1014 → 1072
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1087 → 1140
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    COG1196
    Location:397 → 726
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15236
    Location:349 → 426
    CCDC66; Coiled-coil domain-containing protein 66
    cd21577
    Location:106 → 192
    KLF3_N; N-terminal domain of Kruppel-like factor 3

  7. XM_019943136.2 → XP_019798695.1  intersectin-2 isoform X1

    UniProtKB/TrEMBL
    A0A2U4BZV3
    Conserved Domains (13) summary
    cd08375
    Location:1512 → 1646
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:720 → 776
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:859 → 910
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:942 → 993
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1014 → 1072
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1087 → 1140
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1171 → 1351
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam09756
    Location:365 → 425
    DDRGK; DDRGK domain
    pfam15279
    Location:90 → 170
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:776 → 859
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1369 → 1511
    PH_13; Pleckstrin homology domain
    cl25732
    Location:397 → 726
    SMC_N; RecF/RecN/SMC N terminal domain

  8. XM_019943138.2 → XP_019798697.1  intersectin-2 isoform X2

    UniProtKB/TrEMBL
    A0A2U4BZY6
    Conserved Domains (13) summary
    cd08375
    Location:1498 → 1632
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:1 → 93
    EH; Eps15 homology domain
    cd11988
    Location:706 → 762
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:845 → 896
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:928 → 979
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1000 → 1058
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1073 → 1126
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1157 → 1337
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam09756
    Location:351 → 411
    DDRGK; DDRGK domain
    pfam15279
    Location:76 → 156
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:762 → 845
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1355 → 1497
    PH_13; Pleckstrin homology domain
    cl25732
    Location:383 → 712
    SMC_N; RecF/RecN/SMC N terminal domain

  9. XM_019943134.2 → XP_019798693.1  intersectin-2 isoform X1

    UniProtKB/TrEMBL
    A0A2U4BZV3
    Conserved Domains (13) summary
    cd08375
    Location:1512 → 1646
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:720 → 776
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:859 → 910
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:942 → 993
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1014 → 1072
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1087 → 1140
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1171 → 1351
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam09756
    Location:365 → 425
    DDRGK; DDRGK domain
    pfam15279
    Location:90 → 170
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:776 → 859
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1369 → 1511
    PH_13; Pleckstrin homology domain
    cl25732
    Location:397 → 726
    SMC_N; RecF/RecN/SMC N terminal domain

  10. XM_019943135.2 → XP_019798694.1  intersectin-2 isoform X1

    UniProtKB/TrEMBL
    A0A2U4BZV3
    Related
    ENSTTRP00000018677.1, ENSTTRT00000035715.1
    Conserved Domains (13) summary
    cd08375
    Location:1512 → 1646
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:720 → 776
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:859 → 910
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:942 → 993
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1014 → 1072
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1087 → 1140
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1171 → 1351
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam09756
    Location:365 → 425
    DDRGK; DDRGK domain
    pfam15279
    Location:90 → 170
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:776 → 859
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1369 → 1511
    PH_13; Pleckstrin homology domain
    cl25732
    Location:397 → 726
    SMC_N; RecF/RecN/SMC N terminal domain

  11. XM_019943140.2 → XP_019798699.1  intersectin-2 isoform X4

    UniProtKB/TrEMBL
    A0A2U4BZV7
    Conserved Domains (14) summary
    cd08375
    Location:1439 → 1573
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:165 → 244
    EH; Eps15 homology domain
    cd11988
    Location:647 → 703
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:786 → 837
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:869 → 920
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:941 → 999
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1014 → 1067
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1098 → 1278
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam09756
    Location:292 → 352
    DDRGK; DDRGK domain
    pfam15279
    Location:17 → 97
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:703 → 786
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1296 → 1438
    PH_13; Pleckstrin homology domain
    cl25732
    Location:324 → 653
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27812
    Location:1 → 34
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  12. XM_019943143.2 → XP_019798702.1  intersectin-2 isoform X4

    UniProtKB/TrEMBL
    A0A2U4BZV7
    Conserved Domains (14) summary
    cd08375
    Location:1439 → 1573
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:165 → 244
    EH; Eps15 homology domain
    cd11988
    Location:647 → 703
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:786 → 837
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:869 → 920
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:941 → 999
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1014 → 1067
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1098 → 1278
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam09756
    Location:292 → 352
    DDRGK; DDRGK domain
    pfam15279
    Location:17 → 97
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:703 → 786
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1296 → 1438
    PH_13; Pleckstrin homology domain
    cl25732
    Location:324 → 653
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27812
    Location:1 → 34
    EF-hand_4; Cytoskeletal-regulatory complex EF hand
Nucleotide Protein
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