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SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 [ Orcinus orca (killer whale) ]

Gene ID: 101284580, updated on 8-Mar-2024

Summary

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Gene symbol
SOS2
Gene description
SOS Ras/Rho guanine nucleotide exchange factor 2
See related
EnsemblRapid:ENSOORG00010014528
Gene type
protein coding
RefSeq status
MODEL
Organism
Orcinus orca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Orcinus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_02 current mOrcOrc1.1 (GCF_937001465.1) 2 NC_064560.1 (151440116..151539958, complement)

Chromosome 2 - NC_064560.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC117201398 Neighboring gene valosin containing protein lysine methyltransferase Neighboring gene U1 spliceosomal RNA Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene histone PARylation factor 1-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_064560.1 Chromosome 2 Reference mOrcOrc1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
son of sevenless homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_937001465.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrcOrc1.1 Primary Assembly

Genomic

  1. NC_064560.1 Reference mOrcOrc1.1 Primary Assembly

    Range
    151440116..151539958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004270035.3 → XP_004270083.1  son of sevenless homolog 2 isoform X2

    Related
    ENSOORP00010018801.1, ENSOORT00010021600.1
    Conserved Domains (7) summary
    smart00229
    Location:595 → 739
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:207 → 387
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00155
    Location:774 → 1013
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:437 → 543
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:63 → 169
    Histone; Core histone H2A/H2B/H3/H4
    pfam00169
    Location:443 → 544
    PH; PH domain
    cl23907
    Location:97 → 147
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

  2. XM_049706299.1 → XP_049562256.1  son of sevenless homolog 2 isoform X3

  3. XM_049706298.1 → XP_049562255.1  son of sevenless homolog 2 isoform X1

Nucleotide Protein
Heading Accession and Version

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