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CLCN4 chloride voltage-gated channel 4 [ Orcinus orca (killer whale) ]

Gene ID: 101284297, updated on 8-Mar-2024

Summary

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Gene symbol
CLCN4
Gene description
chloride voltage-gated channel 4
See related
EnsemblRapid:ENSOORG00010010431
Gene type
protein coding
RefSeq status
MODEL
Organism
Orcinus orca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Orcinus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_02 current mOrcOrc1.1 (GCF_937001465.1) X NC_064580.1 (7657914..7740381)

Chromosome X - NC_064580.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC125963099 Neighboring gene shroom family member 2 Neighboring gene V-type proton ATPase subunit G 1-like Neighboring gene uncharacterized LOC117199787 Neighboring gene WWC family member 3 Neighboring gene uncharacterized LOC125963093 Neighboring gene transfer RNA aspartic acid (anticodon AUC) Neighboring gene midline 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_064580.1 Chromosome X Reference mOrcOrc1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables voltage-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
H(+)/Cl(-) exchange transporter 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_937001465.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrcOrc1.1 Primary Assembly

Genomic

  1. NC_064580.1 Reference mOrcOrc1.1 Primary Assembly

    Range
    7657914..7740381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_033420208.2 → XP_033276099.1  H(+)/Cl(-) exchange transporter 4 isoform X3

    Conserved Domains (2) summary
    cd03684
    Location:78 → 584
    ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
    cd04591
    Location:595 → 745
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

  2. XM_049704917.1 → XP_049560874.1  H(+)/Cl(-) exchange transporter 4 isoform X3

    Related
    ENSOORP00010013070.1, ENSOORT00010015331.1

  3. XM_049704918.1 → XP_049560875.1  H(+)/Cl(-) exchange transporter 4 isoform X4

  4. XM_049704916.1 → XP_049560873.1  H(+)/Cl(-) exchange transporter 4 isoform X1

  5. XM_033420204.2 → XP_033276095.1  H(+)/Cl(-) exchange transporter 4 isoform X2

    Conserved Domains (2) summary
    cd03684
    Location:102 → 608
    ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
    cd04591
    Location:619 → 769
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
Nucleotide Protein
Heading Accession and Version

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