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PTPN4 protein tyrosine phosphatase non-receptor type 4 [ Orcinus orca (killer whale) ]

Gene ID: 101280417, updated on 8-Mar-2024

Summary

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Gene symbol
PTPN4
Gene description
protein tyrosine phosphatase non-receptor type 4
See related
EnsemblRapid:ENSOORG00010001057
Gene type
protein coding
RefSeq status
MODEL
Organism
Orcinus orca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Orcinus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_02 current mOrcOrc1.1 (GCF_937001465.1) 7 NC_064565.1 (6284288..6462923, complement)

Chromosome 7 - NC_064565.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 185B Neighboring gene erythrocyte membrane protein band 4.1 like 5 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC125964966 Neighboring gene uncharacterized LOC125964968 Neighboring gene transmembrane protein 177

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_064565.1 Chromosome 7 Reference mOrcOrc1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_937001465.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrcOrc1.1 Primary Assembly

Genomic

  1. NC_064565.1 Reference mOrcOrc1.1 Primary Assembly

    Range
    6284288..6462923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004276902.4 → XP_004276950.1  tyrosine-protein phosphatase non-receptor type 4 isoform X4

    Related
    ENSOORP00010000851.1, ENSOORT00010001362.1
    Conserved Domains (8) summary
    smart00194
    Location:657 → 910
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:682 → 909
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:515 → 602
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:122 → 214
    FERM_B-lobe; FERM domain B-lobe
    pfam08736
    Location:325 → 365
    FA; FERM adjacent (FA)
    pfam09379
    Location:33 → 97
    FERM_N; FERM N-terminal domain

  2. XM_033400230.2 → XP_033256121.1  tyrosine-protein phosphatase non-receptor type 4 isoform X3

  3. XM_033400232.2 → XP_033256123.1  tyrosine-protein phosphatase non-receptor type 4 isoform X5

    Conserved Domains (5) summary
    smart00295
    Location:30 → 229
    B41; Band 4.1 homologues
    cd00992
    Location:522 → 609
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:223 → 317
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:330 → 372
    FA; FERM adjacent (FA)
    cl28904
    Location:648 → 904
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. XM_033400231.2 → XP_033256122.1  tyrosine-protein phosphatase non-receptor type 4 isoform X5

    Conserved Domains (5) summary
    smart00295
    Location:30 → 229
    B41; Band 4.1 homologues
    cd00992
    Location:522 → 609
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:223 → 317
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:330 → 372
    FA; FERM adjacent (FA)
    cl28904
    Location:648 → 904
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  5. XM_033400229.2 → XP_033256120.1  tyrosine-protein phosphatase non-receptor type 4 isoform X2

  6. XM_033400228.2 → XP_033256119.1  tyrosine-protein phosphatase non-receptor type 4 isoform X1

    Conserved Domains (5) summary
    smart00295
    Location:30 → 229
    B41; Band 4.1 homologues
    cd00992
    Location:522 → 609
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:223 → 317
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:330 → 372
    FA; FERM adjacent (FA)
    cl28904
    Location:648 → 904
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  7. XM_049712112.1 → XP_049568069.1  tyrosine-protein phosphatase non-receptor type 4 isoform X1

Nucleotide Protein
Heading Accession and Version

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