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FGFR1 fibroblast growth factor receptor 1 [ Orcinus orca (killer whale) ]

Gene ID: 101279623, updated on 8-Mar-2024

Summary

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Gene symbol
FGFR1
Gene description
fibroblast growth factor receptor 1
See related
EnsemblRapid:ENSOORG00010002014
Gene type
protein coding
RefSeq status
MODEL
Organism
Orcinus orca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Orcinus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_02 current mOrcOrc1.1 (GCF_937001465.1) 21 NC_064579.1 (5587999..5636066)

Chromosome 21 - NC_064579.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC125962839 Neighboring gene transforming acidic coiled-coil containing protein 1 Neighboring gene basic proline-rich protein-like Neighboring gene leucine zipper and EF-hand containing transmembrane protein 2 Neighboring gene glutathione S-transferase LANCL1-like Neighboring gene nuclear receptor binding SET domain protein 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_064579.1 Chromosome 21 Reference mOrcOrc1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fibroblast growth factor receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_937001465.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrcOrc1.1 Primary Assembly

Genomic

  1. NC_064579.1 Reference mOrcOrc1.1 Primary Assembly

    Range
    5587999..5636066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_033415043.2 → XP_033270934.1  fibroblast growth factor receptor 1 isoform X6

    Conserved Domains (6) summary
    cd05098
    Location:462 → 763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:369 → 398
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:253 → 256
    Ig; Ig strand A [structural motif]
    cd04973
    Location:25 → 118
    IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cd05857
    Location:151 → 245
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:253 → 357
    Ig; Immunoglobulin domain

  2. XM_049704317.1 → XP_049560274.1  fibroblast growth factor receptor 1 isoform X1

    Related
    ENSOORP00010001941.1, ENSOORT00010002737.1

  3. XM_049704318.1 → XP_049560275.1  fibroblast growth factor receptor 1 isoform X2

  4. XM_004284890.4 → XP_004284938.1  fibroblast growth factor receptor 1 isoform X3

    See identical proteins and their annotated locations for XP_004284938.1

    Related
    ENSOORP00010001939.1, ENSOORT00010002735.1
    Conserved Domains (5) summary
    cd04973
    Location:40 → 118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163 → 247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:270 → 359
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:462 → 763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:371 → 400
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain

  5. XM_033415046.2 → XP_033270937.1  fibroblast growth factor receptor 1 isoform X4

    Conserved Domains (5) summary
    cd05098
    Location:373 → 674
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:282 → 311
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:166 → 169
    Ig; Ig strand A [structural motif]
    cd05857
    Location:64 → 158
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:166 → 270
    Ig; Immunoglobulin domain

  6. XM_033415047.2 → XP_033270938.1  fibroblast growth factor receptor 1 isoform X5

    Related
    ENSOORP00010001942.1, ENSOORT00010002738.1
    Conserved Domains (5) summary
    cd05098
    Location:371 → 672
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:280 → 309
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:164 → 167
    Ig; Ig strand A [structural motif]
    cd05857
    Location:62 → 156
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:164 → 268
    Ig; Immunoglobulin domain
Nucleotide Protein
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