U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LRP8 LDL receptor related protein 8 [ Orcinus orca (killer whale) ]

Gene ID: 101277017, updated on 8-Mar-2024

Summary

Go to the top of the page Help
Gene symbol
LRP8
Gene description
LDL receptor related protein 8
See related
EnsemblRapid:ENSOORG00010008486
Gene type
protein coding
RefSeq status
MODEL
Organism
Orcinus orca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Orcinus
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_02 current mOrcOrc1.1 (GCF_937001465.1) 1 NC_064559.1 (168209590..168287589)

Chromosome 1 - NC_064559.1Genomic Context describing neighboring genes Neighboring gene phosphate carrier protein, mitochondrial-like Neighboring gene uncharacterized LOC117202865 Neighboring gene mago homolog, exon junction complex subunit Neighboring gene CXXC motif containing zinc binding protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_064559.1 Chromosome 1 Reference mOrcOrc1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
low-density lipoprotein receptor-related protein 8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_937001465.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrcOrc1.1 Primary Assembly

Genomic

  1. NC_064559.1 Reference mOrcOrc1.1 Primary Assembly

    Range
    168209590..168287589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004273833.3 → XP_004273881.1  low-density lipoprotein receptor-related protein 8 isoform X16

    Related
    ENSOORP00010010554.1, ENSOORT00010012498.1
    Conserved Domains (9) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:354 → 396
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:241 → 271
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:364 → 402
    NHL; NHL repeat [structural motif]
    pfam00057
    Location:163 → 198
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam14670
    Location:205 → 239
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    pfam15756
    Location:632 → 704
    DUF4690; Domain of unknown function (DUF4690)
    cl18310
    Location:358 → 542
    NHL; NHL repeat unit of beta-propeller proteins

  2. XM_033435473.2 → XP_033291364.1  low-density lipoprotein receptor-related protein 8 isoform X1

    Conserved Domains (8) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:549 → 591
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:436 → 466
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:291 → 326
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:612 → 652
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam08693
    Location:876 → 914
    SKG6; Transmembrane alpha-helix domain
    pfam14670
    Location:400 → 434
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. XM_033435484.2 → XP_033291375.1  low-density lipoprotein receptor-related protein 8 isoform X14

    Conserved Domains (9) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:378 → 420
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:265 → 295
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl18310
    Location:382 → 566
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:120 → 155
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:441 → 481
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam08693
    Location:705 → 743
    SKG6; Transmembrane alpha-helix domain
    pfam14670
    Location:229 → 263
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  4. XM_033435474.2 → XP_033291365.1  low-density lipoprotein receptor-related protein 8 isoform X2

    Conserved Domains (8) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:536 → 578
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:423 → 453
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:291 → 326
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:599 → 639
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam08693
    Location:863 → 901
    SKG6; Transmembrane alpha-helix domain
    pfam14670
    Location:387 → 421
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  5. XM_033435477.2 → XP_033291368.1  low-density lipoprotein receptor-related protein 8 isoform X4

    Conserved Domains (8) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:508 → 550
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:395 → 425
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:291 → 326
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:571 → 611
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam08693
    Location:835 → 873
    SKG6; Transmembrane alpha-helix domain
    pfam14670
    Location:359 → 393
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  6. XM_033435482.2 → XP_033291373.1  low-density lipoprotein receptor-related protein 8 isoform X11

    Conserved Domains (8) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:421 → 463
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:308 → 338
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:163 → 198
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:484 → 524
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam08693
    Location:748 → 786
    SKG6; Transmembrane alpha-helix domain
    pfam14670
    Location:272 → 306
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  7. XM_049699845.1 → XP_049555802.1  low-density lipoprotein receptor-related protein 8 isoform X17

  8. XM_033435476.2 → XP_033291367.1  low-density lipoprotein receptor-related protein 8 isoform X3

    Conserved Domains (8) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:523 → 565
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:410 → 440
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:291 → 326
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:586 → 626
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam08693
    Location:850 → 888
    SKG6; Transmembrane alpha-helix domain
    pfam14670
    Location:374 → 408
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  9. XM_033435480.2 → XP_033291371.1  low-density lipoprotein receptor-related protein 8 isoform X7

    Conserved Domains (9) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:483 → 525
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:370 → 400
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl18310
    Location:487 → 671
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:291 → 326
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:546 → 586
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam08693
    Location:810 → 848
    SKG6; Transmembrane alpha-helix domain
    pfam14670
    Location:691 → 728
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  10. XM_033435478.2 → XP_033291369.1  low-density lipoprotein receptor-related protein 8 isoform X5

    Conserved Domains (8) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:495 → 537
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:382 → 412
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:291 → 326
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:558 → 598
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam08693
    Location:822 → 860
    SKG6; Transmembrane alpha-helix domain
    pfam14670
    Location:346 → 380
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  11. XM_004273831.3 → XP_004273879.1  low-density lipoprotein receptor-related protein 8 isoform X8

    Related
    ENSOORP00010010550.1, ENSOORT00010012494.1
    Conserved Domains (9) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:482 → 524
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:369 → 399
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:492 → 530
    NHL; NHL repeat [structural motif]
    pfam00057
    Location:291 → 326
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam14670
    Location:333 → 367
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    pfam15756
    Location:760 → 832
    DUF4690; Domain of unknown function (DUF4690)
    cl18310
    Location:486 → 670
    NHL; NHL repeat unit of beta-propeller proteins

  12. XM_033435481.2 → XP_033291372.1  low-density lipoprotein receptor-related protein 8 isoform X9

    Conserved Domains (9) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:442 → 484
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:329 → 359
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl18310
    Location:446 → 630
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:291 → 326
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:505 → 545
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam08693
    Location:769 → 807
    SKG6; Transmembrane alpha-helix domain
    pfam14670
    Location:650 → 687
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  13. XM_033435483.2 → XP_033291374.1  low-density lipoprotein receptor-related protein 8 isoform X12

    Conserved Domains (9) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:395 → 437
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:282 → 312
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl18310
    Location:399 → 583
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:163 → 198
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:458 → 498
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam08693
    Location:722 → 760
    SKG6; Transmembrane alpha-helix domain
    pfam14670
    Location:246 → 280
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  14. XM_049699833.1 → XP_049555790.1  low-density lipoprotein receptor-related protein 8 isoform X13

  15. XM_033435479.2 → XP_033291370.1  low-density lipoprotein receptor-related protein 8 isoform X6

    Conserved Domains (9) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:549 → 591
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:436 → 466
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl18310
    Location:553 → 737
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:291 → 326
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:612 → 652
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam08693
    Location:876 → 914
    SKG6; Transmembrane alpha-helix domain
    pfam14670
    Location:400 → 434
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  16. XM_049699836.1 → XP_049555793.1  low-density lipoprotein receptor-related protein 8 isoform X15

  17. XM_049699849.1 → XP_049555806.1  low-density lipoprotein receptor-related protein 8 isoform X18

  18. XM_004273832.3 → XP_004273880.1  low-density lipoprotein receptor-related protein 8 isoform X10

    Related
    ENSOORP00010010561.1, ENSOORT00010012505.1
    Conserved Domains (9) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:482 → 524
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:369 → 399
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:492 → 530
    NHL; NHL repeat [structural motif]
    pfam00057
    Location:291 → 326
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam14670
    Location:333 → 367
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    pfam15756
    Location:760 → 832
    DUF4690; Domain of unknown function (DUF4690)
    cl18310
    Location:486 → 670
    NHL; NHL repeat unit of beta-propeller proteins

  19. XM_004273834.3 → XP_004273882.1  low-density lipoprotein receptor-related protein 8 isoform X19

    Related
    ENSOORP00010010555.1, ENSOORT00010012499.1
    Conserved Domains (8) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:313 → 355
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:200 → 230
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:323 → 361
    NHL; NHL repeat [structural motif]
    pfam14670
    Location:164 → 198
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    pfam15756
    Location:591 → 663
    DUF4690; Domain of unknown function (DUF4690)
    cl18310
    Location:317 → 501
    NHL; NHL repeat unit of beta-propeller proteins

  20. XM_033435485.2 → XP_033291376.1  low-density lipoprotein receptor-related protein 8 isoform X20

    Related
    ENSOORP00010010562.1, ENSOORT00010012506.1
    Conserved Domains (9) summary
    smart00192
    Location:79 → 111
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:354 → 396
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:241 → 271
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:41 → 75
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl18310
    Location:358 → 542
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:163 → 198
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:417 → 457
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam08693
    Location:681 → 719
    SKG6; Transmembrane alpha-helix domain
    pfam14670
    Location:205 → 239
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.