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PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [ Ovis aries (sheep) ]

Gene ID: 101117419, updated on 8-Mar-2024

Summary

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Gene symbol
PAICS
Gene description
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
See related
EnsemblRapid:ENSOARG00020027525
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human all
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Genomic context

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Location:
chromosome: 6
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 6 NC_056059.1 (72511474..72578995)

Chromosome 6 - NC_056059.1Genomic Context describing neighboring genes Neighboring gene capping protein inhibiting regulator of actin dynamics Neighboring gene aminoadipate-semialdehyde dehydrogenase Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene signal recognition particle 72 Neighboring gene ADP ribosylation factor like GTPase 9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056059.1 Chromosome 6 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Names
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056059.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    72511474..72578995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_060417133.1 → XP_060273116.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X8

  2. XM_042251427.2 → XP_042107361.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X11

    Conserved Domains (3) summary
    cd01416
    Location:320 → 571
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:581 → 734
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
    cl23759
    Location:55 → 122
    GT1; myb-like, SANT family

  3. XM_060417135.1 → XP_060273118.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X10

  4. XM_060417139.1 → XP_060273122.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X13

  5. XM_060417137.1 → XP_060273120.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X11

  6. XM_060417136.1 → XP_060273119.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X10

  7. XM_060417138.1 → XP_060273121.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X12

  8. XM_060417132.1 → XP_060273115.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X7

  9. XM_060417140.1 → XP_060273123.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X14

  10. XM_060417134.1 → XP_060273117.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X9

  11. XM_060417130.1 → XP_060273113.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X1

  12. XM_027971014.2 → XP_027826815.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X3

  13. XM_042251425.1 → XP_042107359.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X4

    Conserved Domains (3) summary
    cd01416
    Location:424 → 675
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:685 → 838
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
    cl23759
    Location:181 → 248
    GT1; myb-like, SANT family

  14. XM_060417131.1 → XP_060273114.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X2

  15. XM_027971015.2 → XP_027826816.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X5

  16. XM_042251426.1 → XP_042107360.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X6

    Conserved Domains (3) summary
    cd01416
    Location:394 → 645
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:655 → 808
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
    cl23759
    Location:181 → 248
    GT1; myb-like, SANT family

  17. XM_042251428.1 → XP_042107362.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X15

    UniProtKB/TrEMBL
    W5P7K2
    Related
    ENSOARP00020045652.1, ENSOART00020072037.1
    Conserved Domains (2) summary
    cd01416
    Location:38 → 289
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:299 → 452
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein

  18. XM_027971017.2 → XP_027826818.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X16

    UniProtKB/TrEMBL
    W5P228

  19. XM_027971016.3 → XP_027826817.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X16

    UniProtKB/TrEMBL
    W5P228
Nucleotide Protein Strain
Heading Accession and Version

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