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LOC101075161 triple functional domain protein [ Takifugu rubripes (torafugu) ]

Gene ID: 101075161, updated on 21-Dec-2023

Summary

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Gene symbol
LOC101075161
Gene description
triple functional domain protein
See related
Ensembl:ENSTRUG00000012584
Gene type
protein coding
RefSeq status
MODEL
Organism
Takifugu rubripes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu
Also known as
trio
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Genomic context

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See LOC101075161 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
63
Annotation release Status Assembly Chr Location
103 current fTakRub1.2 (GCF_901000725.2) 12 NC_042296.1 (5516241..5555832, complement)
101 previous assembly FUGU5 (GCF_000180615.1) 12 NC_018901.1 (4621472..4660984, complement)

Chromosome 12 - NC_042296.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L14 Neighboring gene growth factor receptor-bound protein 10-like Neighboring gene adenylate cyclase 2b (brain) Neighboring gene terminal nucleotidyltransferase 4A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
triple functional domain protein
Names
trio Rho guanine nucleotide exchange factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Takifugu rubripes Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fTakRub1.2 Primary Assembly

Genomic

  1. NC_042296.1 Reference fTakRub1.2 Primary Assembly

    Range
    5516241..5555832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_029844706.1 → XP_029700566.1  triple functional domain protein isoform X2

    UniProtKB/TrEMBL
    A0A674NB45
    Conserved Domains (11) summary
    smart00150
    Location:1146 → 1246
    SPEC; Spectrin repeats
    cd11852
    Location:1672 → 1731
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2550 → 2608
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:58 → 196
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1986 → 2159
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:570 → 786
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1475 → 1607
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2164 → 2302
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam07679
    Location:2680 → 2771
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1729 → 1979
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl21453
    Location:2783 → 3045
    PKc_like; Protein Kinases, catalytic domain

  2. XM_029844705.1 → XP_029700565.1  triple functional domain protein isoform X1

    UniProtKB/TrEMBL
    A0A674NB45
    Related
    ENSTRUP00000070441.1, ENSTRUT00000083112.1
    Conserved Domains (11) summary
    smart00150
    Location:1146 → 1246
    SPEC; Spectrin repeats
    cd11852
    Location:1672 → 1731
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2550 → 2608
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:58 → 196
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1986 → 2159
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:570 → 786
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1475 → 1607
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2164 → 2302
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam07679
    Location:2681 → 2772
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1729 → 1979
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl21453
    Location:2784 → 3046
    PKc_like; Protein Kinases, catalytic domain

  3. XM_029844707.1 → XP_029700567.1  triple functional domain protein isoform X4

    UniProtKB/TrEMBL
    H2U4J3
    Conserved Domains (11) summary
    smart00150
    Location:1146 → 1246
    SPEC; Spectrin repeats
    cd11852
    Location:1662 → 1721
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2540 → 2598
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:58 → 196
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1976 → 2149
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:570 → 786
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1475 → 1597
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2154 → 2292
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam07679
    Location:2670 → 2761
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1719 → 1969
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl21453
    Location:2773 → 3035
    PKc_like; Protein Kinases, catalytic domain

  4. XM_011609025.2 → XP_011607327.2  triple functional domain protein isoform X3

    UniProtKB/TrEMBL
    H2U4J3
    Related
    ENSTRUP00000031855.3, ENSTRUT00000031978.3
    Conserved Domains (11) summary
    smart00150
    Location:1146 → 1246
    SPEC; Spectrin repeats
    cd11852
    Location:1662 → 1721
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2540 → 2598
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:58 → 196
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1976 → 2149
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:570 → 786
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1475 → 1597
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2154 → 2292
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam07679
    Location:2671 → 2762
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1719 → 1969
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl21453
    Location:2774 → 3036
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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