Format

Send to:

Choose Destination

TSPAN2 tetraspanin 2 [ Homo sapiens (human) ]

Gene ID: 10100, updated on 26-May-2016
Official Symbol
TSPAN2provided by HGNC
Official Full Name
tetraspanin 2provided by HGNC
Primary source
HGNC:HGNC:20659
See related
Ensembl:ENSG00000134198 HPRD:18233; MIM:613133; Vega:OTTHUMG00000011878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET3; TSN2; TSPAN-2
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Orthologs
Location:
1p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (115048011..115089500, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (115590632..115632121, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene synaptonemal complex protein 1 Neighboring gene uncharacterized LOC105378915 Neighboring gene thyroid stimulating hormone beta Neighboring gene uncharacterized LOC105378916 Neighboring gene uncharacterized LOC105378917

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12082

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
astrocyte development IEA
Inferred from Electronic Annotation
more info
 
axon development IEA
Inferred from Electronic Annotation
more info
 
brain development IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
microglia development IEA
Inferred from Electronic Annotation
more info
 
myelination IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tetraspanin-2
Names
new EST tetraspan 3
tetraspan 2
tetraspan NET-3
tetraspan TM4SF
tetraspanin 2 isoform

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308315.1NP_001295244.1  tetraspanin-2 isoform 2

    See identical proteins and their annotated locations for NP_001295244.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 2, which has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AA724831, AK022144, AU117697, AW015874, AW051326, BG697236, CB993308
    Consensus CDS
    CCDS76193.1
    UniProtKB/TrEMBL
    B1AKP1
    Conserved Domains (2) summary
    cd03151
    Location:85161
    CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10189
    Tetraspannin; Tetraspanin family
  2. NM_001308316.1NP_001295245.1  tetraspanin-2 isoform 3

    See identical proteins and their annotated locations for NP_001295245.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 3, which has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AA724831, AK022144, AU117697, AW015874, AW051326, BG697236, CB993308, GU971730
    UniProtKB/Swiss-Prot
    O60636
    Conserved Domains (2) summary
    cl02781
    Location:110169
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:10158
    Tetraspannin; Tetraspanin family
  3. NM_005725.5NP_005716.2  tetraspanin-2 isoform 1

    See identical proteins and their annotated locations for NP_005716.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA724831, AK022144, AK315385, AU117697, AW015874, AW051326, BG697236, CB993308
    Consensus CDS
    CCDS881.1
    UniProtKB/Swiss-Prot
    O60636
    UniProtKB/TrEMBL
    B2RD31
    Related
    ENSP00000358529, OTTHUMP00000013651, ENST00000369516, OTTHUMT00000032828
    Conserved Domains (2) summary
    cd03151
    Location:110186
    CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10214
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    115048011..115089500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270340.2XP_005270397.1  

    Related
    ENSP00000415256, OTTHUMP00000038317, ENST00000433172, OTTHUMT00000097471
    Conserved Domains (2) summary
    cl02781
    Location:110169
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:10158
    Tetraspannin; Tetraspanin family
  2. XM_011540459.1XP_011538761.1  

    Related
    ENSP00000358528, OTTHUMP00000013652, ENST00000369515, OTTHUMT00000032829
    Conserved Domains (2) summary
    cd03151
    Location:85161
    CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10189
    Tetraspannin; Tetraspanin family

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    115705876..115747377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)