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    TSPAN3 tetraspanin 3 [ Homo sapiens ]

    Gene ID: 10099, updated on 11-May-2012
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    Summary

    Official Symbol
    TSPAN3provided by HGNC
    Official Full Name
    tetraspanin 3provided by HGNC
    Primary source
    HGNC:17752
    See related
    Ensembl:ENSG00000140391; HPRD:15512; MIM:613134; Vega:OTTHUMG00000143728
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TM4-A; TM4SF8; TSPAN-3
    Summary
    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Dec 2009]
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    Genomic context

    Location :
    15q24.3
    Sequence :
    Chromosome: 15; NC_000015.9 (77336359..77363570, complement)
    See TSPAN3 in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene keratin 8 pseudogene 23 Neighboring gene proline-serine-threonine phosphatase interacting protein 1 Neighboring gene NKF3 kinase family member Neighboring gene long intergenic non-protein coding RNA 597 Neighboring gene non-histone chromosomal protein HMG-17 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965.
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
    5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743.

    See all (13) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O60637 O75508 CLDN11    HPRD  PubMed  
    O60637 Q01844 EWSR1    HPRD  PubMed  
    BioGRID:115406 BioGRID:108431 EWSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:115406 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    tetraspanin-3
    Names
    tetraspanin-3
    tetraspan 3
    tetraspan TM4SF
    tetraspanin TM4-A
    transmembrane 4 superfamily member 8
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168412.1 → NP_001161884.1  tetraspanin-3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AA554982, AC090181, AK298157, DA359645, DB449004
      Consensus CDS
      CCDS53963.1
      Related
      ENSP00000407243, OTTHUMP00000248852, ENST00000424443, OTTHUMT00000419460
      Conserved Domains (1) summary
      cd03163
      Location:40 – 146
      Blast Score: 457
      TM4SF8_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    2. NM_005724.5 → NP_005715.1  tetraspanin-3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA554982, AC090181, BC011206, DA359645
      Consensus CDS
      CCDS10292.1
      UniProtKB/Swiss-Prot
      O60637
      Related
      ENSP00000267970, OTTHUMP00000184898, ENST00000267970, OTTHUMT00000289792
      Conserved Domains (2) summary
      cd03163
      Location:104 – 210
      Blast Score: 473
      TM4SF8_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:9 – 236
      Blast Score: 374
      Tetraspannin; Tetraspanin family

    3. NM_198902.2 → NP_944492.1  tetraspanin-3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AA554982, AC090181, AK075482, DA359645, DB449004
      Consensus CDS
      CCDS10293.1
      UniProtKB/Swiss-Prot
      O60637
      Related
      ENSP00000341329, OTTHUMP00000184899, ENST00000346495, OTTHUMT00000289793
      Conserved Domains (2) summary
      cd03163
      Location:84 – 185
      Blast Score: 438
      TM4SF8_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:9 – 211
      Blast Score: 340
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      77336359..77363570, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      54093221..54120428, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC090181.9 (100714..127582) None
    genomic CH471136.2 EAW99209.1
      EAW99210.1
      EAW99211.1
    mRNA AA554982.1 None
    mRNA AF054840.1 AAC69716.1
    mRNA AF133423.1 AAF08362.1
    mRNA AK001305.1 BAA91613.1
    mRNA AK001310.1 BAA91615.1
    mRNA AK001326.1 BAA91627.1
    mRNA AK027793.1 None
    mRNA AK075336.1 BAG52114.1
    mRNA AK075482.1 BAG52152.1
    mRNA AK293677.1 BAG57119.1
    mRNA AK298157.1 BAG60431.1
    mRNA BC000704.2 AAH00704.1
    mRNA BC004280.1 AAH04280.1
    mRNA BC009248.2 AAH09248.1
    mRNA BC011206.1 AAH11206.1
    mRNA DA359645.1 None
    mRNA DB449004.1 None
    mRNA M69023.1 None
    other-genetic HQ447244.1 ADQ31731.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60637.1 GenPept UniProtKB/Swiss-Prot:O60637
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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