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MCL1 MCL1 apoptosis regulator, BCL2 family member [ Pan paniscus (pygmy chimpanzee) ]

Gene ID: 100979595, updated on 8-Mar-2024

Summary

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Gene symbol
MCL1
Gene description
MCL1 apoptosis regulator, BCL2 family member
See related
Ensembl:ENSPPAG00000038714
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan paniscus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanPan1-v2.0_pri (GCF_029289425.2) 1 NC_073249.2 (99257840..99264868)
RS_2023_05 previous assembly NHGRI_mPanPan1-v1.1-0.1.freeze_pri (GCF_029289425.1) 1 NC_073249.1 (99013464..99018758)

Chromosome 1 - NC_073249.2Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA40 Neighboring gene eukaryotic translation initiation factor 3 subunit F-like Neighboring gene uncharacterized protein ADAMTSL4-AS1 Neighboring gene ADAMTS like 4 Neighboring gene uncharacterized LOC103785884

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
induced myeloid leukemia cell differentiation protein Mcl-1
Names
BCL2 family apoptosis regulator
MCL1, BCL2 family apoptosis regulator
myeloid cell leukemia sequence 1 (BCL2-related)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_029289425.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

Genomic

  1. NC_073249.2 Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

    Range
    99257840..99264868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008970466.4 → XP_008968714.1  induced myeloid leukemia cell differentiation protein Mcl-1 isoform X2

    See identical proteins and their annotated locations for XP_008968714.1

    UniProtKB/TrEMBL
    A0A2R9BSZ8
    Related
    ENSPPAP00000031573.1
    Conserved Domains (1) summary
    cl02575
    Location:175 → 230
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

  2. XM_003817308.5 → XP_003817356.1  induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1

    See identical proteins and their annotated locations for XP_003817356.1

    UniProtKB/TrEMBL
    A0A2R9BYH6
    Related
    ENSPPAP00000031567.1
    Conserved Domains (2) summary
    cd06845
    Location:175 → 318
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    cl00232
    Location:30 → 122
    Ribosomal_L19e; Ribosomal protein L19e. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an extended segment. ...
Nucleotide Protein
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