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MUTYH mutY DNA glycosylase [ Otolemur garnettii (small-eared galago) ]

Gene ID: 100965263, updated on 8-Mar-2024

Summary

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Gene symbol
MUTYH
Gene description
mutY DNA glycosylase
See related
Ensembl:ENSOGAG00000003981
Gene type
protein coding
RefSeq status
MODEL
Organism
Otolemur garnettii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes; Galagidae; Otolemur
Orthologs
human mouse all
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Genomic context

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See MUTYH in Genome Data Viewer
Location:
chromosome: Un
Exon count:
16
Annotation release Status Assembly Chr Location
102 current OtoGar3 (GCF_000181295.1) Unplaced Scaffold NW_003852597.1 (248022..255800)

NW_003852597.1Genomic Context describing neighboring genes Neighboring gene dual specificity testis-specific protein kinase 2 Neighboring gene U6 spliceosomal RNA Neighboring gene target of EGR1, exonuclease Neighboring gene 4-hydroxyphenylpyruvate dioxygenase like Neighboring gene succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_003852597 Unplaced Scaffold Reference OtoGar3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables adenine/guanine mispair binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidized purine DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables purine-specific mismatch base pair DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in base-excision repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mismatch repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
adenine DNA glycosylase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Otolemur garnettii Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference OtoGar3

Genomic

  1. NW_003852597.1 Reference OtoGar3

    Range
    248022..255800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003801183.3 → XP_003801231.1  adenine DNA glycosylase

    UniProtKB/TrEMBL
    H0WNW4
    Related
    ENSOGAP00000003546.2, ENSOGAT00000003984.2
    Conserved Domains (4) summary
    smart00525
    Location:261 → 280
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:58 → 467
    MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]
    cd00056
    Location:100 → 258
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:359 → 470
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
Nucleotide Protein
Heading Accession and Version

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