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TCF7L2 transcription factor 7 like 2 [ Sarcophilus harrisii (Tasmanian devil) ]

Gene ID: 100922675, updated on 8-Mar-2024

Summary

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Gene symbol
TCF7L2
Gene description
transcription factor 7 like 2
See related
Ensembl:ENSSHAG00000022847
Gene type
protein coding
RefSeq status
MODEL
Organism
Sarcophilus harrisii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
18
Annotation release Status Assembly Chr Location
103 current mSarHar1.11 (GCF_902635505.1) 2 NC_045427.1 (569018438..569246183)
102 previous assembly Devil_ref v7.0 (GCF_000189315.1) 1 Unlocalized Scaffold NW_003816473.1 (2651820..2883440, complement)

Chromosome 2 - NC_045427.1Genomic Context describing neighboring genes Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene uncharacterized LOC105749267 Neighboring gene uncharacterized LOC116421894 Neighboring gene U6 spliceosomal RNA Neighboring gene hyaluronan binding protein 2 Neighboring gene nebulin related anchoring protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of catenin-TCF7L2 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transcription factor 7-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sarcophilus harrisii Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mSarHar1.11 Primary Assembly

Genomic

  1. NC_045427.1 Reference mSarHar1.11 Primary Assembly

    Range
    569018438..569246183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012541082.3 → XP_012396536.1  transcription factor 7-like 2 isoform X3

    Conserved Domains (2) summary
    cd01388
    Location:354 → 421
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  2. XM_012541077.3 → XP_012396531.1  transcription factor 7-like 2 isoform X1

    Conserved Domains (2) summary
    cd01388
    Location:358 → 425
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  3. XM_031955861.1 → XP_031811721.1  transcription factor 7-like 2 isoform X2

    Conserved Domains (2) summary
    cd01388
    Location:358 → 425
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  4. XM_023495820.2 → XP_023351588.1  transcription factor 7-like 2 isoform X6

    Conserved Domains (2) summary
    cd01388
    Location:358 → 425
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  5. XM_012541091.3 → XP_012396545.1  transcription factor 7-like 2 isoform X7

    Conserved Domains (2) summary
    cd01388
    Location:358 → 425
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  6. XM_012541087.3 → XP_012396541.1  transcription factor 7-like 2 isoform X5

    Conserved Domains (2) summary
    cd01388
    Location:349 → 416
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  7. XM_012541097.3 → XP_012396551.1  transcription factor 7-like 2 isoform X10

    Conserved Domains (2) summary
    cd01388
    Location:335 → 402
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  8. XM_012541114.3 → XP_012396568.1  transcription factor 7-like 2 isoform X13

    Conserved Domains (2) summary
    cd01388
    Location:335 → 402
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  9. XM_031955863.1 → XP_031811723.1  transcription factor 7-like 2 isoform X17

    UniProtKB/TrEMBL
    A0A7N4PKD9
    Conserved Domains (2) summary
    cd01388
    Location:358 → 425
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  10. XM_031955869.1 → XP_031811729.1  transcription factor 7-like 2 isoform X22

    UniProtKB/TrEMBL
    A0A7N4PKD9
    Conserved Domains (2) summary
    cd01388
    Location:358 → 425
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  11. XM_031955864.1 → XP_031811724.1  transcription factor 7-like 2 isoform X17

    UniProtKB/TrEMBL
    A0A7N4PKD9
    Conserved Domains (2) summary
    cd01388
    Location:358 → 425
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  12. XM_003755361.4 → XP_003755409.1  transcription factor 7-like 2 isoform X4

    UniProtKB/TrEMBL
    A0A7N4NG60
    Related
    ENSSHAP00000022763.1, ENSSHAT00000035545.1
    Conserved Domains (2) summary
    cd01388
    Location:353 → 420
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  13. XM_023495824.2 → XP_023351592.1  transcription factor 7-like 2 isoform X8

    Conserved Domains (2) summary
    cd01388
    Location:353 → 420
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  14. XM_003755362.4 → XP_003755410.1  transcription factor 7-like 2 isoform X9

    Conserved Domains (2) summary
    cd01388
    Location:353 → 420
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  15. XM_012541107.3 → XP_012396561.1  transcription factor 7-like 2 isoform X12

    Conserved Domains (2) summary
    cd01388
    Location:326 → 393
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  16. XM_023495839.2 → XP_023351607.1  transcription factor 7-like 2 isoform X16

    Conserved Domains (2) summary
    cd01388
    Location:326 → 393
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  17. XM_031955865.1 → XP_031811725.1  transcription factor 7-like 2 isoform X18

    UniProtKB/TrEMBL
    A0A7N4PKD9
    Related
    ENSSHAP00000039801.1, ENSSHAT00000025870.1
    Conserved Domains (2) summary
    cd01388
    Location:358 → 425
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  18. XM_031955866.1 → XP_031811726.1  transcription factor 7-like 2 isoform X18

    UniProtKB/TrEMBL
    A0A7N4PKD9
    Conserved Domains (2) summary
    cd01388
    Location:358 → 425
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  19. XM_003755358.4 → XP_003755406.1  transcription factor 7-like 2 isoform X11

    UniProtKB/TrEMBL
    A0A7N4P9A7
    Related
    ENSSHAP00000035052.1, ENSSHAT00000038344.1
    Conserved Domains (2) summary
    cd01388
    Location:330 → 397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  20. XM_023495837.2 → XP_023351605.1  transcription factor 7-like 2 isoform X14

    Conserved Domains (2) summary
    cd01388
    Location:330 → 397
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  21. XM_003755360.4 → XP_003755408.1  transcription factor 7-like 2 isoform X15

    Conserved Domains (2) summary
    cd01388
    Location:330 → 397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  22. XM_023495849.2 → XP_023351617.1  transcription factor 7-like 2 isoform X26

    UniProtKB/TrEMBL
    A0A7N4PTG1
    Conserved Domains (2) summary
    cd01388
    Location:358 → 425
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  23. XM_031955867.1 → XP_031811727.1  transcription factor 7-like 2 isoform X19

    UniProtKB/TrEMBL
    A0A7N4PKD9
    Conserved Domains (2) summary
    cd01388
    Location:358 → 425
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  24. XM_023495840.2 → XP_023351608.1  transcription factor 7-like 2 isoform X23

    UniProtKB/TrEMBL
    A0A7N4PKD9
    Conserved Domains (2) summary
    cd01388
    Location:349 → 416
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  25. XM_012541130.3 → XP_012396584.1  transcription factor 7-like 2 isoform X24

    UniProtKB/TrEMBL
    A0A7N4PKD9, G3WYE8
    Related
    ENSSHAP00000020453.2, ENSSHAT00000020616.2
    Conserved Domains (2) summary
    cd01388
    Location:335 → 402
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  26. XM_023495864.2 → XP_023351632.1  transcription factor 7-like 2 isoform X31

    UniProtKB/TrEMBL
    A0A7N4PKD9
    Conserved Domains (2) summary
    cd01388
    Location:326 → 393
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  27. XM_023495859.2 → XP_023351627.1  transcription factor 7-like 2 isoform X28

    UniProtKB/TrEMBL
    A0A7N4PTG1
    Conserved Domains (2) summary
    cd01388
    Location:349 → 416
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  28. XM_023495847.2 → XP_023351615.1  transcription factor 7-like 2 isoform X25

    UniProtKB/TrEMBL
    A0A7N4PKD9
    Conserved Domains (2) summary
    cd01388
    Location:330 → 397
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  29. XM_023495854.2 → XP_023351622.1  transcription factor 7-like 2 isoform X27

    UniProtKB/TrEMBL
    A0A7N4PTG1
    Conserved Domains (2) summary
    cd01388
    Location:353 → 420
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  30. XM_012541127.3 → XP_012396581.1  transcription factor 7-like 2 isoform X21

    UniProtKB/TrEMBL
    A0A7N4P2P3, A0A7N4PKD9
    Related
    ENSSHAP00000031802.1, ENSSHAT00000042238.1
    Conserved Domains (2) summary
    cd01388
    Location:353 → 420
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 259
    CTNNB1_binding; N-terminal CTNNB1 binding

  31. XM_012541138.3 → XP_012396592.1  transcription factor 7-like 2 isoform X30

    UniProtKB/TrEMBL
    A0A7N4PKD9
    Conserved Domains (2) summary
    cd01388
    Location:326 → 393
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  32. XM_023495868.2 → XP_023351636.1  transcription factor 7-like 2 isoform X32

    UniProtKB/TrEMBL
    A0A7N4PTG1
    Related
    ENSSHAP00000043138.1, ENSSHAT00000051693.1
    Conserved Domains (2) summary
    cd01388
    Location:330 → 397
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  33. XM_012541135.3 → XP_012396589.1  transcription factor 7-like 2 isoform X29

    UniProtKB/TrEMBL
    A0A7N4PKD9
    Conserved Domains (2) summary
    cd01388
    Location:330 → 397
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  34. XM_031955868.1 → XP_031811728.1  transcription factor 7-like 2 isoform X20

    Conserved Domains (2) summary
    cd01388
    Location:210 → 277
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:42 → 116
    CTNNB1_binding; N-terminal CTNNB1 binding
Nucleotide Protein
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