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ROCK2 Rho associated coiled-coil containing protein kinase 2 [ Sarcophilus harrisii (Tasmanian devil) ]

Gene ID: 100916865, updated on 8-Mar-2024

Summary

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Gene symbol
ROCK2
Gene description
Rho associated coiled-coil containing protein kinase 2
See related
Ensembl:ENSSHAG00000012229
Gene type
protein coding
RefSeq status
MODEL
Organism
Sarcophilus harrisii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
32
Annotation release Status Assembly Chr Location
103 current mSarHar1.11 (GCF_902635505.1) 2 NC_045427.1 (113535620..113660923, complement)
102 previous assembly Devil_ref v7.0 (GCF_000189315.1) 1 Unlocalized Scaffold NW_003816737.1 (992148..1118961)

Chromosome 2 - NC_045427.1Genomic Context describing neighboring genes Neighboring gene chromosome 2 C2orf50 homolog Neighboring gene solute carrier family 66 member 3 Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene uncharacterized LOC116421390 Neighboring gene germ cell-less 1, spermatogenesis associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in actomyosin structure organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in embryonic morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of centrosome duplication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell junction assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho-associated protein kinase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sarcophilus harrisii Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mSarHar1.11 Primary Assembly

Genomic

  1. NC_045427.1 Reference mSarHar1.11 Primary Assembly

    Range
    113535620..113660923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012540157.3 → XP_012395611.1  rho-associated protein kinase 2 isoform X1

    UniProtKB/TrEMBL
    G3WFV9
    Conserved Domains (7) summary
    cd11638
    Location:505 → 571
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    smart00220
    Location:91 → 353
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:437 → 1101
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1263 → 1309
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1153 → 1259
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    pfam08912
    Location:979 → 1046
    Rho_Binding; Rho Binding
    cl21453
    Location:38 → 415
    PKc_like; Protein Kinases, catalytic domain

  2. XM_012540158.3 → XP_012395612.1  rho-associated protein kinase 2 isoform X2

    UniProtKB/TrEMBL
    G3WFV9
    Related
    ENSSHAP00000014314.2, ENSSHAT00000014433.2
    Conserved Domains (7) summary
    cd11638
    Location:505 → 571
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    smart00220
    Location:91 → 353
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:437 → 1101
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1261 → 1307
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1151 → 1257
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    pfam08912
    Location:979 → 1046
    Rho_Binding; Rho Binding
    cl21453
    Location:38 → 415
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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