CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) [Homo sapiens] - Gene

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Summary

Official Symbol: CDH11provided by HGNC
Official Full Name: cadherin 11, type 2, OB-cadherin (osteoblast)provided by HGNC
Primary source: HGNC:1750
See related: Ensembl:ENSG00000140937; HPRD:08960; MIM:600023; Vega:OTTHUMG00000137494
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OB; CAD11; CDHOB; OSF-4
Summary: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 16q21

Sequence :: Chromosome: 16; NC_000016.9 (64980683..65155919, complement)

See CDH11 in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CDH11 expression was assessed in lung tissue from idiopathic pulmonary fibrosis patients.
Title: Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition.
increased expression in patients with rheumatoid arthritis
Title: IL-17 increases cadherin-11 expression in a model of autoimmune experimental arthritis and in rheumatoid arthritis.
cad-11 modulates synovial fibroblasts to evoke inflammatory factors that may contribute to the inflammatory process in RA.
Title: Cadherin-11 regulates fibroblast inflammation.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
suppression of MUC1 by miR-145 causes a reduction of beta-catenin as well as the oncogenic cadherin 11
Title: MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1.
Cadherin-11 mRNA and protein levels are regulated by the activity of GSK3beta and a significant degree of this regulation is exerted by the GSK3 target, beta-catenin, at the level of the cadherin-11 3'UTR
Title: Post-transcriptional regulation of cadherin-11 expression by GSK-3 and beta-catenin in prostate and breast cancer cells.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
Cadherin-11 and fascin might be useful markers for recurrence of pleomorphic adenomas.
Title: Recurrence of pleomorphic adenoma of the parotid gland--predictive value of cadherin-11 and fascin.
Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation
Title: Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation.
These findings suggest that cadherin-11 is involved in the metastasis of prostate cancer cells to bone.
Title: Cadherin-11 promotes the metastasis of prostate cancer cells to bone.

Submit: New GeneRIF Correction See all (20)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001788.2	Cadherin 2	CDH2	HPRD	PubMed
NP_001788.2	NP_001895.1	CTNNB1	HPRD	PubMed
NP_001788.2	Alpha Catenin		HPRD	PubMed
P55287	P19022	CDH2	HPRD	PubMed
P55287	P35222	CTNNB1	HPRD	PubMed
BioGRID:107444	BioGRID:107435	CDH2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107444	BioGRID:107880	CTNNB1	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
adherens junction organization	TAS Traceable Author Statement more info
cell adhesion	TAS Traceable Author Statement more info	PubMed
cell junction assembly	TAS Traceable Author Statement more info
cell-cell adhesion	NAS Non-traceable Author Statement more info
cell-cell junction organization	TAS Traceable Author Statement more info
homophilic cell adhesion	NAS Non-traceable Author Statement more info
ossification	NAS Non-traceable Author Statement more info	PubMed
skeletal system development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
integral to membrane	NAS Non-traceable Author Statement more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: cadherin-11

Names: cadherin-11

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029491.1 RefSeqGene

Range

5001..180237

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001797.2 → NP_001788.2 cadherin-11 preproprotein

Status: REVIEWED

Source sequence(s)

D21254

Consensus CDS

CCDS10803.1

UniProtKB/Swiss-Prot

P55287

Related

ENSP00000268603, OTTHUMP00000174770, ENST00000268603, OTTHUMT00000268755

Conserved Domains (2) summary

pfam01049
Location:641 – 789
Blast Score: 533

Cadherin_C; Cadherin cytoplasmic region

cd11304
Location:163 – 264
Blast Score: 271

Cadherin_repeat; Cadherin tandem repeat domain.

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p5 Primary Assembly

Range

64980683..65155919, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

50850425..51025603, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC010533.6 (75316..153587)	None
genomic	AC137643.3 (54424..151388)	None
genomic	AF060369.1	AAD27755.1
genomic	AF060370.1	AAD27756.1
genomic	CH471092.1	EAW83000.1
		EAW83001.1
		EAW83002.1
mRNA	AB209760.1	BAD92997.1
mRNA	AK291251.1	BAF83940.1
mRNA	AK294872.1	BAH11907.1
mRNA	AK297377.1	BAG59819.1
mRNA	AK308000.1	None
mRNA	BC013609.1	AAH13609.1
mRNA	D21254.1	BAA04798.1
mRNA	D21255.1	BAA04799.1
mRNA	L34056.1	AAA35622.1
other-genetic	JF432268.1	ADZ15485.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P55287.2	GenPept	UniProtKB/Swiss-Prot:P55287
Q59EQ1	GenPept	UniProtKB/TrEMBL:Q59EQ1
Q96CZ9	GenPept	UniProtKB/TrEMBL:Q96CZ9