CDH10 cadherin 10, type 2 (T2-cadherin) [Homo sapiens] - Gene

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Summary

Official Symbol: CDH10provided by HGNC
Official Full Name: cadherin 10, type 2 (T2-cadherin)provided by HGNC
Primary source: HGNC:1749
See related: Ensembl:ENSG00000040731; HPRD:05187; MIM:604555; Vega:OTTHUMG00000090667
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. [provided by RefSeq, Jan 2011]

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Genomic context

Location :: 5p14.2

Sequence :: Chromosome: 5; NC_000005.9 (24487209..24645085, complement)

See CDH10 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Common genetic variants on 5p14.1 associate with autism spectrum disorders.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Common genetic variants on 5p14.1 associate with autism spectrum disorders.

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9Y6N8	P55285	CDH6	HPRD	PubMed
Q9Y6N8	Q9ULB4	CDH9	HPRD	PubMed
Q9Y6N8	Q7L5N1	COPS6	HPRD	PubMed
Q9Y6N8	P21246	PTN	HPRD	PubMed
BioGRID:107443	BioGRID:116176	COPS6	BioGRID	PubMed	Two-hybrid
BioGRID:107443	BioGRID:107880	CTNNB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107443	BioGRID:111731	PTN	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
adherens junction organization	TAS Traceable Author Statement more info
cell junction assembly	TAS Traceable Author Statement more info
cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
cell-cell junction organization	TAS Traceable Author Statement more info
homophilic cell adhesion	NAS Non-traceable Author Statement more info

Component	Evidence Code	Pubs
integral to membrane	NAS Non-traceable Author Statement more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: cadherin-10

Names: cadherin-10; T2-cadherin

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006727.3 → NP_006718.2 cadherin-10 preproprotein

Status: REVIEWED

Source sequence(s)

AA209467, AB035303, DA229466

Consensus CDS

CCDS3892.1

UniProtKB/Swiss-Prot

Q9Y6N8

Related

ENSP00000264463, OTTHUMP00000115830, ENST00000264463, OTTHUMT00000207345

Conserved Domains (2) summary

pfam01049
Location:636 – 782
Blast Score: 498

Cadherin_C; Cadherin cytoplasmic region

cd11304
Location:164 – 265
Blast Score: 267

Cadherin_repeat; Cadherin tandem repeat domain.

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

24487209..24645085, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

24451668..24610300, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001190450.1: Suppressed sequence

Description

NM_001190450.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC010387.5 (161530..173413)	None
genomic	AC091885.2 (13267..159084)	None
genomic	CH471118.1	EAX10742.1
mRNA	AA209467.1	None
mRNA	AB035303.1	BAA87417.1
mRNA	BC144168.1	None
mRNA	BM126883.1	None
mRNA	DA229466.1	None
other-genetic	BC152828.1	AAI52829.1
other-genetic	BC156818.1	AAI56819.1