Pkm pyruvate kinase M1/2 [Cricetulus griseus (Chinese hamster)] - Gene

Summary

Gene symbol: Pkm
Gene description: pyruvate kinase M1/2
Locus tag: I79_004880
See related: Ensembl:ENSCGRG00015023319
Gene type: protein coding
RefSeq status: MODEL
Organism: Cricetulus griseus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
104	current	CriGri_1.0 (GCF_000223135.1)	Unplaced Scaffold	NW_003613709.1 (200602..223767)
104	current	CriGri-PICRH-1.0 (GCF_003668045.3)	4	NC_048597.1 (171202707..171226027)

NW_003613709.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables potassium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables pyruvate kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: pyruvate kinase PKM

Names: Pyruvate kinase isozymes M1/M2; pyruvate kinase, muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

NW_003613709.1 Reference CriGri_1.0 Primary Assembly

Range

200602..223767

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_016973075.3 → XP_016828564.1 pyruvate kinase PKM isoform X3

UniProtKB/TrEMBL

A0A8C2LLE5, A0A8C2LMS2

Conserved Domains (2) summary

cd00288
Location:42 → 530

Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

TIGR01064
Location:43 → 527

pyruv_kin; pyruvate kinase
XM_016973069.3 → XP_016828558.2 pyruvate kinase PKM isoform X2

UniProtKB/TrEMBL

A0A8C2LLE5, A0A9J7JQV6

Conserved Domains (1) summary

cd00288
Location:102 → 590

Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
XM_035450085.1 → XP_035305976.1 pyruvate kinase PKM isoform X1

UniProtKB/TrEMBL

A0A8C2LLE5, A0A9J7K853

Conserved Domains (1) summary

cd00288
Location:102 → 590

Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
XM_016973079.3 → XP_016828568.1 pyruvate kinase PKM isoform X4

UniProtKB/TrEMBL

A0A9J7FZM3, G3H3Q1

Conserved Domains (2) summary

cd00288
Location:68 → 515

Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

TIGR01064
Location:68 → 512

pyruv_kin; pyruvate kinase

Alternate CriGri-PICRH-1.0

Genomic

NC_048597.1 Alternate CriGri-PICRH-1.0

Range

171202707..171226027

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_027414873.1 → XP_027270674.1 pyruvate kinase PKM isoform X3

UniProtKB/TrEMBL

A0A8C2LLE5, A0A8C2LMS2

Related

ENSCGRP00015050942.1, ENSCGRT00015055128.1
XM_027414872.2 → XP_027270673.2 pyruvate kinase PKM isoform X2

UniProtKB/TrEMBL

A0A8C2LLE5, A0A9J7JQV6

Related

ENSCGRP00015030982.1, ENSCGRT00015037883.2

Conserved Domains (1) summary

cd00288
Location:102 → 590

Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
XM_035443746.1 → XP_035299637.1 pyruvate kinase PKM isoform X1

UniProtKB/TrEMBL

A0A8C2LLE5, A0A9J7K853

Related

ENSCGRP00015030972.2, ENSCGRT00015037869.2

Conserved Domains (1) summary

cd00288
Location:102 → 590

Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
XM_027414874.1 → XP_027270675.1 pyruvate kinase PKM isoform X4

UniProtKB/TrEMBL

A0A9J7FZM3, G3H3Q1