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PDE2A phosphodiesterase 2A [ Sus scrofa (pig) ]

Gene ID: 100737701, updated on 8-Mar-2024

Summary

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Official Symbol
PDE2Aprovided by VGNC
Official Full Name
phosphodiesterase 2Aprovided by VGNC
Primary source
VGNC:VGNC:91251
See related
Ensembl:ENSSSCG00000029388
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in subcutaneous adipose (RPKM 12.7), heart (RPKM 8.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
35
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 9 NC_010451.4 (7136637..7227966, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 9 NC_010451.3 (7896906..7988379, complement)

Chromosome 9 - NC_010451.4Genomic Context describing neighboring genes Neighboring gene paired like homeobox 2A Neighboring gene ClpB family mitochondrial disaggregase Neighboring gene cytochrome c pseudogene Neighboring gene uncharacterized LOC110262210 Neighboring gene uncharacterized LOC106504277 Neighboring gene microRNA mir-139 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Neighboring gene StAR related lipid transfer domain containing 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  2. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cGMP catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cGMP-dependent 3',5'-cyclic phosphodiesterase
Names
phosphodiesterase 2A, cGMP-stimulated

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010451.4 Reference Sscrofa11.1 Primary Assembly

    Range
    7136637..7227966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003482557.4 → XP_003482605.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3

    UniProtKB/TrEMBL
    A0A4X1UYP9, F1SUV3
    Related
    ENSSSCP00000015734.4, ENSSSCT00000016167.4
    Conserved Domains (3) summary
    smart00065
    Location:413 → 562
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:659 → 892
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam10411
    Location:195 → 245
    DsbC_N; Disulfide bond isomerase protein N-terminus

  2. XM_013999451.2 → XP_013854905.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X6

    UniProtKB/TrEMBL
    A0A4X1UWB2
    Related
    ENSSSCP00000025730.3, ENSSSCT00000031538.3
    Conserved Domains (3) summary
    smart00065
    Location:389 → 538
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:635 → 868
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam10411
    Location:171 → 221
    DsbC_N; Disulfide bond isomerase protein N-terminus

  3. XM_021102285.1 → XP_020957944.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X5

    UniProtKB/TrEMBL
    A0A481CZF0, A0A8D1D6S3, A0A8D1NDF4
    Related
    ENSSSCP00000047136.3, ENSSSCT00000066369.3
    Conserved Domains (3) summary
    smart00065
    Location:412 → 561
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:658 → 888
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    cl26534
    Location:194 → 244
    DsbC_N; Disulfide bond isomerase protein N-terminus

  4. XM_021102284.1 → XP_020957943.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X4

    UniProtKB/TrEMBL
    A0A4X1UWB2
    Conserved Domains (3) summary
    smart00065
    Location:412 → 561
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:658 → 888
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    cl26534
    Location:194 → 244
    DsbC_N; Disulfide bond isomerase protein N-terminus

  5. XM_005653692.3 → XP_005653749.2  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X2

    UniProtKB/TrEMBL
    A0A4X1UWB2
    Conserved Domains (3) summary
    smart00065
    Location:449 → 598
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:695 → 928
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam10411
    Location:231 → 281
    DsbC_N; Disulfide bond isomerase protein N-terminus

  6. XM_013999446.2 → XP_013854900.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1

    UniProtKB/TrEMBL
    A0A287B1D3, A0A8D0QSN6, A0A8D1EAS9
    Related
    ENSSSCP00000050215.2, ENSSSCT00000065606.3
    Conserved Domains (3) summary
    smart00065
    Location:461 → 610
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:707 → 940
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam10411
    Location:243 → 293
    DsbC_N; Disulfide bond isomerase protein N-terminus
Nucleotide Protein
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